HUMAN:MAVS

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAVS (synonyms: IPS1, KIAA1271, VISA)
Protein Name(s)	Mitochondrial antiviral-signaling protein MAVS CARD adapter inducing interferon beta Cardif Interferon beta promoter stimulator protein 1 IPS-1 Putative NF-kappa-B-activating protein 031N Virus-induced-signaling adapter VISA
External Links
UniProt	Q7Z434
EMBL	DQ174270 DQ167126 DQ181928 AB232371 EF467323 EF467324 KC415005 AB033097 AB097003 AK023799 AK123956 AK130992 AK291785 AK296897 AL353194 AL109804 AL109804 AL353194 CH471133 BC044952
CCDS	CCDS33437.1 CCDS56176.1
RefSeq	NP_001193420.1 NP_065797.2
UniGene	Hs.570362
PDB	2VGQ 3J6C 3J6J 4P4H
PDBsum	2VGQ 3J6C 3J6J 4P4H
ProteinModelPortal	Q7Z434
SMR	Q7Z434
BioGrid	121570
DIP	DIP-35445N
IntAct	Q7Z434
MINT	MINT-3034048
PhosphoSite	Q7Z434
DMDM	47115748
MaxQB	Q7Z434
PaxDb	Q7Z434
PeptideAtlas	Q7Z434
PRIDE	Q7Z434
DNASU	57506
Ensembl	ENST00000416600 ENST00000428216
GeneID	57506
KEGG	hsa:57506
UCSC	uc002wjv.3 uc002wjw.4
CTD	57506
GeneCards	GC20P003827
HGNC	HGNC:29233
HPA	CAB009187 HPA053524
MIM	609676
neXtProt	NX_Q7Z434
PharmGKB	PA164722208
eggNOG	NOG79681
GeneTree	ENSGT00510000049120
HOVERGEN	HBG079638
InParanoid	Q7Z434
KO	K12648
OMA	EQDTELG
OrthoDB	EOG71ZP2Z
PhylomeDB	Q7Z434
TreeFam	TF333444
Reactome	REACT_24938 REACT_24969 REACT_25026 REACT_25039 REACT_25271 REACT_25359
SignaLink	Q7Z434
ChiTaRS	MAVS
EvolutionaryTrace	Q7Z434
GeneWiki	VISA_(gene)
GenomeRNAi	57506
NextBio	35464378
PMAP-CutDB	Q7Z434
PRO	PR:Q7Z434
Proteomes	UP000005640
Bgee	Q7Z434
ExpressionAtlas	Q7Z434
Genevestigator	Q7Z434
GO	GO:0016021 GO:0031966 GO:0005741 GO:0005739 GO:0005778 GO:0050700 GO:0019901 GO:0004871 GO:0002218 GO:0071360 GO:0042742 GO:0051607 GO:0045087 GO:0032480 GO:0045071 GO:0071651 GO:0002230 GO:0043123 GO:0032727 GO:0032728 GO:0032757 GO:0071660 GO:0033160 GO:0001934 GO:0051091 GO:0042993 GO:0045944 GO:0032760 GO:0060340 GO:1900063 GO:0039529 GO:0007165 GO:0016032
InterPro	IPR026148
PANTHER	PTHR21446

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:25636800^[1]	ECO:0000314			P		Figure 1A and 3A shows greater IRF3 dimerization in presence of MAVS. IRF3 dimerization leads to type I interferon production.	complete CACAO 11114
	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:25636800^[1]	ECO:0000315			P		Figure 2 shows reduction in IRF3 activation in MAVS truncated mutants	complete CACAO 11119
	GO:0023014	signal transduction by protein phosphorylation	PMID:25636800^[1]	ECO:0000314			P		Figure 1A and 3A shows greater IRF3 dimerization/phosphorylation in presence of MAVS. IRF3 dimerization signals type I interferon production.	complete CACAO 11176
	GO:0023014	signal transduction by protein phosphorylation	PMID:25636800^[1]	ECO:0000315			P		Figure 2 shows reduction in IRF3 activation(phosphorylation) in MAVS truncated mutants	complete CACAO 11177
	GO:0039529	RIG-I signaling pathway	PMID:26243192^[2]	ECO:0000314			P		Figure 1. Inhibition of IPS-1(MAVS) resulted in lowered downstream activity of RIG-1 pathway.	complete CACAO 11190
	GO:0023014	signal transduction by protein phosphorylation	PMID:26243192^[2]	ECO:0000314			P		Figure S1 show MAVS(referred to here as IPS-10) is required for phosphorylation of IRF3	complete CACAO 11206
	GO:0023014	signal transduction by protein phosphorylation	PMID:26243192^[2]	ECO:0000314			P		Figure S1 shows that interference of MAVS (referred to here as IPS-1) causes loss of phosphorylation of downstream signaling molecules	complete CACAO 11210
involved_in	GO:0002735	positive regulation of myeloid dendritic cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8VCF0	P		Seeded From UniProt	complete
involved_in	GO:1902741	positive regulation of interferon-alpha secretion	PMID:21957149^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:21957149^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060760	positive regulation of response to cytokine stimulus	PMID:21957149^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035549	positive regulation of interferon-beta secretion	PMID:21957149^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904469	positive regulation of tumor necrosis factor secretion	PMID:21957149^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	PMID:21957149^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071660	positive regulation of IP-10 production	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:16127453^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050700	CARD domain binding	PMID:16127453^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BYX4	F		Seeded From UniProt	complete
enables	GO:0050700	CARD domain binding	PMID:16127453^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95786	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18818105^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:18818105^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_activity_of:(UniProtKB:Q14653)	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:18818105^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:16127453^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13546	F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:18818105^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:18818105^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:16127453^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900063	regulation of peroxisome organization	PMID:20451243^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:20451243^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(GO:0005739)	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:20451243^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:20451243^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19631370^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19609254^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045071	negative regulation of viral genome replication	PMID:20451243^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[9]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:19631370^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:19631370^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:19609254^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	PMID:19609254^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:20451243^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:20451243^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005778	peroxisomal membrane	PMID:20451243^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000182)	Seeded From UniProt	complete
enables	GO:0035591	signaling adaptor activity	PMID:20451243^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	PMID:19609254^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002725602 UniProtKB:Q7Z434	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2444773 PANTHER:PTN002725602 UniProtKB:Q7Z434 ZFIN:ZDB-GENE-070112-1402	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002725602 UniProtKB:Q7Z434	P		Seeded From UniProt	complete
enables	GO:0035591	signaling adaptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2444773 PANTHER:PTN002725602 UniProtKB:Q7Z434	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2444773 PANTHER:PTN002725602 UniProtKB:Q7Z434 ZFIN:ZDB-GENE-070112-1402	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002725602 UniProtKB:F1S8C6 UniProtKB:Q7Z434 ZFIN:ZDB-GENE-070112-1402	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2444773 PANTHER:PTN002725602 UniProtKB:F1S8C6 UniProtKB:Q7Z434 ZFIN:ZDB-GENE-070112-1402	C		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2444773 PANTHER:PTN002725602 UniProtKB:Q7Z434 ZFIN:ZDB-GENE-070112-1402	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026148	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026148	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	Reactome:R-HSA-168249	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032480	negative regulation of type I interferon production	Reactome:R-HSA-936440	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-990528 Reactome:R-HSA-990526 Reactome:R-HSA-936564 Reactome:R-HSA-936475 Reactome:R-HSA-936381 Reactome:R-HSA-933539 Reactome:R-HSA-933538 Reactome:R-HSA-933537 Reactome:R-HSA-933532 Reactome:R-HSA-933530 Reactome:R-HSA-933527 Reactome:R-HSA-933526 Reactome:R-HSA-933525 Reactome:R-HSA-933523 Reactome:R-HSA-918232 Reactome:R-HSA-918230 Reactome:R-HSA-918229 Reactome:R-HSA-918227 Reactome:R-HSA-918225 Reactome:R-HSA-168934 Reactome:R-HSA-168909	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Okazaki, T et al. (2015) The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci Signal 8 ra78 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Zhang, Z et al. (2011) DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells. J. Immunol. 187 4501-8 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Kawai, T et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6 981-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Zhong, B et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 538-50 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Dixit, E et al. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141 668-81 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Chiu, YH et al. (2009) RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138 576-91 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ablasser, A et al. (2009) RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10 1065-72 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25636800-1] 1.0 ^1.1 ^1.2 ^1.3 Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

[PMID:26243192-2] 2.0 ^2.1 ^2.2 Okazaki, T et al. (2015) The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response. Sci Signal 8 ra78 PubMed GONUTS page

[PMID:21957149-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Zhang, Z et al. (2011) DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells. J. Immunol. 187 4501-8 PubMed GONUTS page

[PMID:16127453-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 ^4.14 Kawai, T et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat. Immunol. 6 981-8 PubMed GONUTS page

[PMID:18818105-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Zhong, B et al. (2008) The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 29 538-50 PubMed GONUTS page

[PMID:20451243-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Dixit, E et al. (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141 668-81 PubMed GONUTS page

[PMID:19631370-7] 7.0 ^7.1 ^7.2 Chiu, YH et al. (2009) RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138 576-91 PubMed GONUTS page

[PMID:19609254-8] 8.0 ^8.1 ^8.2 ^8.3 Ablasser, A et al. (2009) RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat. Immunol. 10 1065-72 PubMed GONUTS page

[PMID:12761501-9] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:MAVS

Contents

Annotations

Notes

References

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