GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
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Cacao
| GO:0060340 | positive regulation of type I interferon-mediated signaling pathway | PMID:25636800 | IMP: Inferred from Mutant Phenotype | P | ||||
| This annotation made on page: HUMAN:MAVS By: Zacharymax (group Team G-nomes) on 2015-11-03 15:20:24 CST. | ||||||||
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| Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
|---|---|---|---|---|
| Challenge | Dyd5192, Team PSU 1 | 2015-11-30 15:26:44 CST | Figure 2 shows how MAVS C terminus harbors a conserved serine-rich region containing Ser442 essential for IRF3 binding and activation. 2A and 2B present an unbiased structure-guided alignment of full-length IRF3, MAVS, and STING across species revealing sequence similarity among the MAVS 4T/S cluster, STING C terminus and the IRF3 5T/S cluster, whose phosphorylation is known to be essential for IRF3 dimerization. Phosphorylation of both IRF3 serine clusters is essential for its dimerization and activation. | 0 |
| Private Assessment | Suzialeksander | 2015-12-07 15:53:19 CST | You need to be an instructor to view these notes. | Unacceptable |
| Public Assessment | DanielRenfro | 2015-11-30 15:26:44 CST | This annotation has been flagged because it has been challenged since last assessment | Flagged |
| Private Assessment | Suzialeksander | 2015-11-12 17:14:35 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ With/From ✗ Notes |
