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HUMAN:MAOX

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ME1
Protein Name(s) NADP-dependent malic enzyme

NADP-ME Malic enzyme 1

External Links
UniProt P48163
EMBL X77244
L34035
AK302777
AK223417
AL391416
AL049699
AL136970
AL049699
AL136970
AL391416
AL136970
AL049699
AL391416
BC025246
U43944
CCDS CCDS34492.1
PIR JC4160
S44415
RefSeq NP_002386.1
UniGene Hs.21160
PDB 2AW5
3WJA
PDBsum 2AW5
3WJA
ProteinModelPortal P48163
SMR P48163
BioGrid 110363
MINT MINT-5004289
STRING 9606.ENSP00000358719
BindingDB P48163
ChEMBL CHEMBL3495
PhosphoSite P48163
DMDM 1346484
REPRODUCTION-2DPAGE IPI00008215
MaxQB P48163
PaxDb P48163
PeptideAtlas P48163
PRIDE P48163
DNASU 4199
Ensembl ENST00000369705
GeneID 4199
KEGG hsa:4199
UCSC uc003pjy.3
CTD 4199
GeneCards GC06M083920
HGNC HGNC:6983
HPA HPA006493
MIM 154250
neXtProt NX_P48163
PharmGKB PA30723
eggNOG COG0281
GeneTree ENSGT00390000000754
HOVERGEN HBG000746
InParanoid P48163
KO K00029
OMA RDVMSKF
OrthoDB EOG7G4QF0
PhylomeDB P48163
TreeFam TF300537
Reactome REACT_116145
SABIO-RK P48163
EvolutionaryTrace P48163
GeneWiki ME1
ME1_(gene)
GenomeRNAi 4199
NextBio 35476406
PRO PR:P48163
Proteomes UP000005640
Bgee P48163
CleanEx HS_ME1
ExpressionAtlas P48163
Genevestigator P48163
GO GO:0005829
GO:0005739
GO:0043531
GO:0009055
GO:0004471
GO:0004473
GO:0004470
GO:0030145
GO:0051287
GO:0050661
GO:0008948
GO:0005975
GO:0044255
GO:0006108
GO:0006741
GO:0051262
GO:0009743
GO:0009725
GO:0044281
Gene3D 3.40.50.10380
3.40.50.720
InterPro IPR015884
IPR012301
IPR012302
IPR001891
IPR016040
Pfam PF00390
PF03949
PIRSF PIRSF000106
PRINTS PR00072
SMART SM00919
PROSITE PS00331

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004470

malic enzyme activity

PMID:23334421[1]

ECO:0000315

F

Fig 1C.

complete
CACAO 7031

GO:1902031

regulation of NADP metabolic process

PMID:23334421[1]

ECO:0000315

P

In figure 2, it is shown that relative to Malic Enzyme mutants that show no enzymatic activity, wild type Malic Enzyme leads to greater production of NADPH in a cell.

complete
CACAO 7477

involved_in

GO:1902031

regulation of NADP metabolic process

PMID:23334421[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:23334421[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

PMID:8187880[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

PMID:7622060[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13697

P

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

PMID:8187880[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

PMID:7622060[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13697

C

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:8187880[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P13697

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:8187880[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:7622060[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006108

malate metabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002719
PANTHER:PTN000601050
PomBase:SPCC794.12c
TAIR:locus:2017854
TAIR:locus:2052045
TAIR:locus:2054085
TAIR:locus:2127038
TAIR:locus:2180547
TAIR:locus:2181980
UniProtKB:P48163
UniProtKB:Q16798

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000601050
PomBase:SPCC794.12c
SGD:S000001512
UniProtKB:Q16798

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001157886
RGD:3074
UniProtKB:F1N3V0
UniProtKB:P23368

C

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002719
MGI:MGI:97043
PANTHER:PTN000601052
RGD:3074
TAIR:locus:2017854
TAIR:locus:2052045
TAIR:locus:2180547
TAIR:locus:2181980
UniProtKB:P48163
UniProtKB:Q16798

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000601050
RGD:3074
SGD:S000001512
UniProtKB:P23368
UniProtKB:P48163
UniProtKB:Q16798

F

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0009055

P

Seeded From UniProt

complete

involved_in

GO:0051262

protein tetramerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06801
ensembl:ENSMUSP00000034989

P

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06801
ensembl:ENSMUSP00000034989

F

Seeded From UniProt

complete

enables

GO:0004470

malic enzyme activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001891

F

Seeded From UniProt

complete

enables

GO:0004471

malate dehydrogenase (decarboxylating) (NAD+) activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001891
InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR037062

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012302

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012301
InterPro:IPR015884
InterPro:IPR037062

P

Seeded From UniProt

complete

enables

GO:0008948

oxaloacetate decarboxylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.40

F

Seeded From UniProt

complete

enables

GO:0004473

malate dehydrogenase (decarboxylating) (NADP+) activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.40

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

PMID:7622060[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0050661

NADP binding

PMID:7622060[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043531

ADP binding

PMID:7622060[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009743

response to carbohydrate

PMID:8187880[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:7622060[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006741

NADP biosynthetic process

PMID:8187880[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019216

regulation of lipid metabolic process

Reactome:R-HSA-400206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006090

pyruvate metabolic process

Reactome:R-HSA-70268

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-9012036
Reactome:R-HSA-1989756

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Jiang, P et al. (2013) Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493 689-93 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Loeber, G et al. (1994) Characterization of cytosolic malic enzyme in human tumor cells. FEBS Lett. 344 181-6 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 González-Manchón, C et al. (1995) Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gene 159 255-60 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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