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HUMAN:MAOM
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ME2 | |
| Protein Name(s) | NAD-dependent malic enzyme, mitochondrial
NAD-ME Malic enzyme 2 | |
| External Links | ||
| UniProt | P23368 | |
| EMBL | M55905 AB045122 AK313391 AC015864 AC087687 CH471096 BC000147 AJ294818 | |
| CCDS | CCDS11948.1 CCDS54187.1 | |
| PIR | A39503 | |
| RefSeq | NP_001161807.1 NP_002387.1 | |
| UniGene | Hs.233119 | |
| PDB | 1DO8 1EFK 1EFL 1GZ3 1GZ4 1PJ2 1PJ3 1PJ4 1PJL 1QR6 | |
| PDBsum | 1DO8 1EFK 1EFL 1GZ3 1GZ4 1PJ2 1PJ3 1PJ4 1PJL 1QR6 | |
| ProteinModelPortal | P23368 | |
| SMR | P23368 | |
| BioGrid | 110364 | |
| IntAct | P23368 | |
| MINT | MINT-4530114 | |
| STRING | 9606.ENSP00000321070 | |
| PhosphoSite | P23368 | |
| DMDM | 126733 | |
| MaxQB | P23368 | |
| PaxDb | P23368 | |
| PeptideAtlas | P23368 | |
| PRIDE | P23368 | |
| DNASU | 4200 | |
| Ensembl | ENST00000321341 ENST00000382927 | |
| GeneID | 4200 | |
| KEGG | hsa:4200 | |
| UCSC | uc002ley.3 uc010dpd.3 | |
| CTD | 4200 | |
| GeneCards | GC18P048405 | |
| HGNC | HGNC:6984 | |
| HPA | HPA008247 HPA008880 | |
| MIM | 154270 | |
| neXtProt | NX_P23368 | |
| PharmGKB | PA30724 | |
| eggNOG | COG0281 | |
| GeneTree | ENSGT00390000000754 | |
| HOGENOM | HOG000042486 | |
| HOVERGEN | HBG000746 | |
| InParanoid | P23368 | |
| KO | K00027 | |
| OMA | KAKYIRE | |
| OrthoDB | EOG7G4QF0 | |
| PhylomeDB | P23368 | |
| TreeFam | TF300537 | |
| SABIO-RK | P23368 | |
| EvolutionaryTrace | P23368 | |
| GeneWiki | ME2 ME2_(gene) | |
| GenomeRNAi | 4200 | |
| NextBio | 16554 | |
| PRO | PR:P23368 | |
| Proteomes | UP000005640 | |
| Bgee | P23368 | |
| CleanEx | HS_ME2 | |
| Genevestigator | P23368 | |
| GO | GO:0043231 GO:0005759 GO:0005739 GO:0009055 GO:0004471 GO:0046872 GO:0051287 GO:0008948 GO:0006108 | |
| Gene3D | 3.40.50.10380 3.40.50.720 | |
| InterPro | IPR015884 IPR012301 IPR012302 IPR001891 IPR016040 | |
| Pfam | PF00390 PF03949 | |
| PIRSF | PIRSF000106 | |
| PRINTS | PR00072 | |
| SMART | SM00919 | |
| PROSITE | PS00331 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004470 |
malic enzyme activity |
ECO:0000315 |
F |
Fig 1C. |
complete | |||||
| GO:1902031 |
regulation of NADP metabolic process |
ECO:0000315 |
P |
As shown in figure 2, the level of NADPH in the cell is comparatively greater in cells with wild type Malic Enzyme 2 than with Malic Enzyme 2 mutants that had no enzymatic activity. |
complete | |||||
|
involved_in |
GO:1902031 |
regulation of NADP metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004470 |
malic enzyme activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006108 |
malate metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002719 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006090 |
pyruvate metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000601050 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001157886 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004473 |
malate dehydrogenase (decarboxylating) (NADP+) activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0002719 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004470 |
malic enzyme activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000601050 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0022900 |
electron transport chain |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009055 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004470 |
malic enzyme activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004471 |
malate dehydrogenase (decarboxylating) (NAD+) activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001891 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0051287 |
NAD binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004471 |
malate dehydrogenase (decarboxylating) (NAD+) activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008948 |
oxaloacetate decarboxylase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004471 |
malate dehydrogenase (decarboxylating) (NAD+) activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0009055 |
electron transfer activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006099 |
tricarboxylic acid cycle |
Reactome:R-HSA-71403 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-9012268 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005759 |
mitochondrial matrix |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Jiang, P et al. (2013) Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493 689-93 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Loeber, G et al. (1991) Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli. J. Biol. Chem. 266 3016-21 PubMed GONUTS page
e
m
- GO:0004473 ! malate dehydrogenase (decarboxylating) (NADP+) activity
- GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity
- GO:0006108 ! malate metabolic process
- GO:0004470 ! malic enzyme activity
- Mammalia
- GO:0008152 ! metabolic process
- GO:0046872 ! metal ion binding
- Metazoa
- GO:0005759 ! mitochondrial matrix
- GO:0005739 ! mitochondrion
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