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HUMAN:MAF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MAF1
Protein Name(s) Repressor of RNA polymerase III transcription MAF1 homolog
External Links
UniProt Q9H063
EMBL AL136937
CR533463
AC104592
CH471162
CH471162
BC014082
BC018714
BC031273
CCDS CCDS6416.1
RefSeq NP_115648.2
UniGene Hs.19673
PDB 3NR5
PDBsum 3NR5
ProteinModelPortal Q9H063
SMR Q9H063
BioGrid 123965
DIP DIP-53028N
IntAct Q9H063
MINT MINT-1424988
STRING 9606.ENSP00000318604
iPTMnet Q9H063
PhosphoSite Q9H063
BioMuta MAF1
DMDM 296434582
EPD Q9H063
MaxQB Q9H063
PaxDb Q9H063
PRIDE Q9H063
DNASU 84232
Ensembl ENST00000322428
ENST00000532522
GeneID 84232
KEGG hsa:84232
UCSC uc003zbc.2
CTD 84232
GeneCards MAF1
H-InvDB HIX0022762
HGNC HGNC:24966
HPA HPA024821
HPA058548
MIM 610210
neXtProt NX_Q9H063
PharmGKB PA142671489
eggNOG KOG3104
COG5046
GeneTree ENSGT00390000006896
HOGENOM HOG000185242
HOVERGEN HBG052395
InParanoid Q9H063
OrthoDB EOG776SQX
PhylomeDB Q9H063
TreeFam TF315149
SIGNOR Q9H063
ChiTaRS MAF1
EvolutionaryTrace Q9H063
GeneWiki MAF1
GenomeRNAi 84232
PRO PR:Q9H063
Proteomes UP000005640
Bgee Q9H063
CleanEx HS_MAF1
ExpressionAtlas Q9H063
Genevisible Q9H063
GO GO:0030424
GO:0005813
GO:0005737
GO:0005829
GO:0030425
GO:0060077
GO:0005622
GO:0043231
GO:0005730
GO:0005654
GO:0005634
GO:0048471
GO:0005886
GO:0000994
GO:0001030
GO:0001031
GO:0001032
GO:0016480
GO:0070217
GO:0006351
InterPro IPR015257
PANTHER PTHR22504
Pfam PF09174
PIRSF PIRSF037240

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016479

negative regulation of transcription from RNA polymerase I promoter

PMID:17499043[1]

ECO:0000314

P

The author analyzed the effect of increasing and decreasing the transcription of MAF1 on polymerase 1 dependent transcription. It was found that RNA polymerase 1 dependent transcription was decreased in the MAF1 upregulated cells (Figure 1)

complete
CACAO 12192

GO:0016480

negative regulation of transcription from RNA polymerase III promoter

PMID:17499043[1]

ECO:0000314

P

The author analyzed the effect of increasing and decreasing the transcription of MAF1 on polymerase 3 dependent transcription. It was found that RNA polymerase 3 dependent transcription was decreased in the MAF1 upregulated cells (Figure 1)

complete
CACAO 12193

involved_in

GO:0016480

negative regulation of transcription by RNA polymerase III

PMID:18377933[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005622

intracellular

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016480

negative regulation of transcription by RNA polymerase III

PMID:20233713[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20233713[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20233713[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:20543138[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001032

RNA polymerase III type 3 promoter DNA binding

PMID:20233713[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001031

RNA polymerase III type 2 promoter DNA binding

PMID:20233713[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0001030

RNA polymerase III type 1 promoter DNA binding

PMID:20233713[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016480

negative regulation of transcription by RNA polymerase III

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0267861
PANTHER:PTN000500453
PomBase:SPAC31G5.12c
SGD:S000002412
UniProtKB:Q9H063

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000500453
SGD:S000002412
UniProtKB:Q9H063
WB:WBGene00016622

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1916127
PANTHER:PTN000500453
RGD:1359315
SGD:S000002412
UniProtKB:Q9H063
WB:WBGene00016622

C

Seeded From UniProt

complete

enables

GO:0001032

RNA polymerase III type 3 promoter DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000500453
UniProtKB:Q9H063

F

Seeded From UniProt

complete

enables

GO:0001031

RNA polymerase III type 2 promoter DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000500453
UniProtKB:Q9H063

F

Seeded From UniProt

complete

enables

GO:0001030

RNA polymerase III type 1 promoter DNA binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000500453
UniProtKB:Q9H063

F

Seeded From UniProt

complete

enables

GO:0000994

RNA polymerase III core binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000500453
SGD:S000002412

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0060077

inhibitory synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

enables

GO:0050811

GABA receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

part_of

GO:0030425

dendrite

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

part_of

GO:0030424

axon

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XIH0
ensembl:ENSRNOP00000018240

C

Seeded From UniProt

complete

involved_in

GO:0016480

negative regulation of transcription by RNA polymerase III

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9D0U6
ensembl:ENSMUSP00000125387

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9D0U6
ensembl:ENSMUSP00000125387

C

Seeded From UniProt

complete

involved_in

GO:0016480

negative regulation of transcription by RNA polymerase III

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR015257

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8944457
Reactome:R-HSA-8944454

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8944457
Reactome:R-HSA-8944420

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Johnson, SS et al. (2007) Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases. Mol. Cell 26 367-79 PubMed GONUTS page
  2. ↑ Goodfellow, SJ et al. (2008) Regulation of RNA polymerase III transcription by Maf1 in mammalian cells. J. Mol. Biol. 378 481-91 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Shor, B et al. (2010) Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J. Biol. Chem. 285 15380-92 PubMed GONUTS page
  4. ↑ Kantidakis, T et al. (2010) mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc. Natl. Acad. Sci. U.S.A. 107 11823-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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