HUMAN:M4K4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAP4K4 (synonyms: HGK, KIAA0687, NIK)
Protein Name(s)	Mitogen-activated protein kinase kinase kinase kinase 4 HPK/GCK-like kinase HGK MAPK/ERK kinase kinase kinase 4 MEK kinase kinase 4 MEKKK 4 Nck-interacting kinase
External Links
UniProt	O95819
EMBL	AF096300 AY212247 AB014587 AL137755 AB013385
CCDS	CCDS56130.1
PIR	T46481
RefSeq	NP_001229488.1 NP_004825.3 NP_663720.1
UniGene	Hs.701013
PDB	4OBO 4OBP 4OBQ 4U43 4U44 4U45
PDBsum	4OBO 4OBP 4OBQ 4U43 4U44 4U45
ProteinModelPortal	O95819
SMR	O95819
BioGrid	114838
IntAct	O95819
MINT	MINT-1172114
STRING	9606.ENSP00000313644
BindingDB	O95819
ChEMBL	CHEMBL6166
GuidetoPHARMACOLOGY	2088
PhosphoSite	O95819
MaxQB	O95819
PaxDb	O95819
PRIDE	O95819
GeneID	9448
KEGG	hsa:9448
UCSC	uc002tbc.3 uc002tbd.3 uc002tbg.3 uc002tbh.3
CTD	9448
GeneCards	GC02P102313
HGNC	HGNC:6866
HPA	HPA008476
MIM	604666
neXtProt	NX_O95819
PharmGKB	PA30612
eggNOG	COG0515
GeneTree	ENSGT00760000118848
HOGENOM	HOG000290708
HOVERGEN	HBG036506
InParanoid	O95819
KO	K04407
PhylomeDB	O95819
TreeFam	TF105138
Reactome	REACT_169436
SignaLink	O95819
ChiTaRS	MAP4K4
GeneWiki	MAP4K4
GenomeRNAi	9448
NextBio	35392
PRO	PR:O95819
Proteomes	UP000005640
Bgee	O95819
CleanEx	HS_MAP4K4
ExpressionAtlas	O95819
Genevestigator	O95819
GO	GO:0005737 GO:0005524 GO:0004674 GO:0005083 GO:0035556 GO:0006468 GO:0046328
InterPro	IPR001180 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00780 PF00069
SMART	SM00036 SM00220
SUPFAM	SSF56112
PROSITE	PS50219 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043066	negative regulation of apoptotic process	PMID:21196414^[1]	ECO:0000315			P		Figure 2D shows that MAP4K4 deals with apoptotic activity.	complete CACAO 2541
	GO:0046329	negative regulation of JNK cascade	PMID:21196414^[1]	ECO:0000315			P		Figure 1C	complete CACAO 2547
	GO:0097179	protease inhibitor complex	PMID:21196414^[1]	ECO:0000315			C		Figure 3C	complete CACAO 2549
	GO:0004111	creatine kinase activity	PMID:23207904^[2]	ECO:0000314			F		Fig 3.	complete CACAO 6625
involved_in	GO:1903393	positive regulation of adherens junction organization	PMID:25490267^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97820	P	occurs_in:(CL:0000312) occurs_in:(GO:0005925)	Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	PMID:25490267^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97820	P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	PMID:25490267^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97820	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:25490267^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97820	P	occurs_in:(CL:0000312) regulates_activity_of:(UniProtKB:P62330)	Seeded From UniProt	complete
involved_in	GO:0032014	positive regulation of ARF protein signal transduction	PMID:25490267^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97820	P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
involved_in	GO:0001953	negative regulation of cell-matrix adhesion	PMID:25490267^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:25490267^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000312)	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:25490267^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000312)	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:24163766^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21196414^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0030033	microvillus assembly	PMID:22797597^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004111	creatine kinase activity	PMID:23207904^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	PMID:14966141^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:9890973^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9890973^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14966141^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9890973^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9890973^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000685430 WB:WBGene00003247	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000198103 PANTHER:PTN000685430	P		Seeded From UniProt	complete
involved_in	GO:0070571	negative regulation of neuron projection regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K7W4 ensembl:ENSRNOP00000074373	P		Seeded From UniProt	complete
involved_in	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K7W4 ensembl:ENSRNOP00000074373	P		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K7W4 ensembl:ENSRNOP00000074373	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Liu, AW et al. (2011) ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth. Clin. Cancer Res. 17 710-20 PubMed GONUTS page
↑ ^2.0 ^2.1 Wang, M et al. (2013) Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation. Mol. Cell. Biol. 33 678-87 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Yue, J et al. (2014) Microtubules regulate focal adhesion dynamics through MAP4K4. Dev. Cell 31 572-85 PubMed GONUTS page
↑ Loftus, JC et al. (2013) A Novel Interaction between Pyk2 and MAP4K4 Is Integrated with Glioma Cell Migration. J Signal Transduct 2013 956580 PubMed GONUTS page
↑ Gloerich, M et al. (2012) Rap2A links intestinal cell polarity to brush border formation. Nat. Cell Biol. 14 793-801 PubMed GONUTS page
↑ ^6.0 ^6.1 Machida, N et al. (2004) Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J. Biol. Chem. 279 15711-4 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Yao, Z et al. (1999) A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J. Biol. Chem. 274 2118-25 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21196414-1] 1.0 ^1.1 ^1.2 ^1.3 Liu, AW et al. (2011) ShRNA-targeted MAP4K4 inhibits hepatocellular carcinoma growth. Clin. Cancer Res. 17 710-20 PubMed GONUTS page

[PMID:23207904-2] 2.0 ^2.1 Wang, M et al. (2013) Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation. Mol. Cell. Biol. 33 678-87 PubMed GONUTS page

[PMID:25490267-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Yue, J et al. (2014) Microtubules regulate focal adhesion dynamics through MAP4K4. Dev. Cell 31 572-85 PubMed GONUTS page

[PMID:24163766-4] Loftus, JC et al. (2013) A Novel Interaction between Pyk2 and MAP4K4 Is Integrated with Glioma Cell Migration. J Signal Transduct 2013 956580 PubMed GONUTS page

[PMID:22797597-5] Gloerich, M et al. (2012) Rap2A links intestinal cell polarity to brush border formation. Nat. Cell Biol. 14 793-801 PubMed GONUTS page

[PMID:14966141-6] 6.0 ^6.1 Machida, N et al. (2004) Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J. Biol. Chem. 279 15711-4 PubMed GONUTS page

[PMID:9890973-7] 7.0 ^7.1 ^7.2 ^7.3 Yao, Z et al. (1999) A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J. Biol. Chem. 274 2118-25 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:M4K4

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