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HUMAN:LN28B
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LIN28B (synonyms: CSDD2) | |
| Protein Name(s) | Protein lin-28 homolog B
Lin-28B | |
| External Links | ||
| UniProt | Q6ZN17 | |
| EMBL | DQ127228 AK131411 Z95329 AL135911 AL135911 Z95329 CH471051 BC127712 BC127713 BC137526 BC137527 BC141960 | |
| CCDS | CCDS34504.1 | |
| RefSeq | NP_001004317.1 | |
| UniGene | Hs.23616 | |
| PDB | 4A4I | |
| PDBsum | 4A4I | |
| ProteinModelPortal | Q6ZN17 | |
| SMR | Q6ZN17 | |
| BioGrid | 133142 | |
| IntAct | Q6ZN17 | |
| STRING | 9606.ENSP00000344401 | |
| iPTMnet | Q6ZN17 | |
| PhosphoSitePlus | Q6ZN17 | |
| BioMuta | LIN28B | |
| DMDM | 74758701 | |
| EPD | Q6ZN17 | |
| MaxQB | Q6ZN17 | |
| PaxDb | Q6ZN17 | |
| PeptideAtlas | Q6ZN17 | |
| PRIDE | Q6ZN17 | |
| Ensembl | ENST00000345080 | |
| GeneID | 389421 | |
| KEGG | hsa:389421 | |
| UCSC | uc003pqv.2 | |
| CTD | 389421 | |
| DisGeNET | 389421 | |
| GeneCards | LIN28B | |
| HGNC | HGNC:32207 | |
| HPA | HPA036630 HPA061745 | |
| MalaCards | LIN28B | |
| MIM | 611044 | |
| neXtProt | NX_Q6ZN17 | |
| OpenTargets | ENSG00000187772 | |
| Orphanet | 635 | |
| PharmGKB | PA142671543 | |
| eggNOG | KOG3070 COG1278 | |
| GeneTree | ENSGT00860000133704 | |
| HOGENOM | HOG000047091 | |
| HOVERGEN | HBG081922 | |
| InParanoid | Q6ZN17 | |
| KO | K18754 | |
| OMA | SETSEWA | |
| OrthoDB | EOG091G0RTY | |
| PhylomeDB | Q6ZN17 | |
| TreeFam | TF316240 | |
| BioCyc | ZFISH:G66-31153-MONOMER | |
| SignaLink | Q6ZN17 | |
| GenomeRNAi | 389421 | |
| PRO | PR:Q6ZN17 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000187772 | |
| CleanEx | HS_LIN28B | |
| Genevisible | Q6ZN17 | |
| GO | GO:0005737 GO:0005730 GO:0003677 GO:0044822 GO:0003723 GO:0008270 GO:0010587 GO:0031054 GO:0006355 GO:0031123 | |
| CDD | cd04458 | |
| Gene3D | 4.10.60.10 | |
| InterPro | IPR011129 IPR002059 IPR012340 IPR001878 | |
| Pfam | PF00313 PF00098 | |
| PRINTS | PR00050 | |
| SMART | SM00357 SM00343 | |
| SUPFAM | SSF50249 SSF57756 | |
| PROSITE | PS50158 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0050779 |
RNA destabilization |
ECO:0000314 |
P |
Figure 4B: Human Lin28b (from recombinant E. coli), when added to cell extract in increasing amounts, increases the amount of uridylated pre-let-7a-1 (up-let-7a-1). Figure 4E: up-let-7a-1 shows decreased stability as compared to pre-let-7a-1. According to the authors, this indicates that "Lin28 mediates the terminal uridylation of pre-let-7 diverting the Dicer processing and irreversibly reroutes pre-let-7 into a decay pathway." |
complete | |||||
|
involved_in |
GO:0031123 |
RNA 3'-end processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:2000627 |
positive regulation of miRNA catabolic process |
ECO:0000315 |
P |
"Lin28b was identified via RNA affinity purification of Huh7 cell extracts with pre-let-7a-1" Fig. 4b shows "in vitro uridylation of pre-let-7a-1 was carried out with purified recombinant Lin28b protein." Fig. 4e shows a quicker decay of target species, pre-let-7a-1, after uridylation by overexpressed human lin28b; up-let-7a-1 is the product of the uridylation of pre-let-7a-1 by lin28b. Called human lin28b. |
complete | |||||
|
involved_in |
GO:0031054 |
pre-miRNA processing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010587 |
miRNA catabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:2000635 |
negative regulation of primary miRNA processing |
ECO:0000314 |
P |
"Lin28b was identified via RNA affinity purification of Huh7 cell extracts with pre-let-7a-1" Figure S11A. Shows inhibition of Drosha processings by Lin28 in vitro "(A) In vitro processing of pri-let-7a-1, pri-let-7g and pri-miR-16-1 by Drosha with recombinant Lin28b (rLin28b) present" Called Lin28b. |
complete | |||||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:2000632 |
negative regulation of pre-miRNA processing |
ECO:0000314 |
P |
"Lin28b was identified via RNA affinity purification of Huh7 cell extracts with pre-let-7a-1" Figure S11B. Shows inhibition of Dicer processings by Lin28 in vitro "(B) In vitro processing of pre-let-7a-1, pre-let-7g and pre-miR-16-1 by Dicer with rLin28b present. " |
complete | |||||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001878 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031047 |
gene silencing by RNA |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Heo, I et al. (2008) Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol. Cell 32 276-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Heo, I et al. (2009) TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138 696-708 PubMed GONUTS page
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