Private Assessment | JimHu | 2017-04-18 13:47:09 CDT | You need to be an instructor to view these notes. | Acceptable
✔ Protein ✔ Publication ✔ Qualifier ✔ Go term ✔ Evidence ✔ With/From ✔ Notes ✔ Unique/Original
|
Public Assessment | DanielRenfro | 2017-04-18 13:13:05 CDT | This annotation has been flagged because it has been edited since last assessment
Qualifier |
GO ID |
GO term name |
Reference |
Evidence Code |
with/from |
Aspect |
Notes |
Status
|
|
GO:2000627 |
positive regulation of miRNA catabolic process |
PMID:18951094 |
IMP: Inferred from Mutant Phenotype |
|
P |
"Lin28b was identified via RNA affinity purification of Huh7 cell extracts with pre-let-7a-1"
Fig. 4b shows "in vitro uridylation of pre-let-7a-1 was carried out with purified recombinant Lin28b protein." Fig. 4e shows a quicker decay of target species, pre-let-7a-1, after uridylation by overexpressed human lin28b; up-let-7a-1 is the product of the uridylation of pre-let-7a-1 by lin28b.
Called human lin28b.||complete CACAO 12255
| on HUMAN:LN28B
| Flagged
|
Public Assessment | DanielRenfro | 2017-04-17 00:00:59 CDT | This annotation has been flagged because it has been edited since last assessment
Qualifier |
GO ID |
GO term name |
Reference |
Evidence Code |
with/from |
Aspect |
Notes |
Status
|
|
GO:2000627 |
positive regulation of miRNA catabolic process |
PMID:18951094 |
IMP: Inferred from Mutant Phenotype |
|
P |
Fig. 4b shows "in vitro uridylation of pre-let-7a-1 was carried out with purified recombinant Lin28b protein." Fig. 4e shows a quicker decay of target species, pre-let-7a-1, after uridylation by overexpressed human lin28b; up-let-7a-1 is the product of the uridylation of pre-let-7a-1 by lin28b. |
complete CACAO 12255
| on HUMAN:LN28B
| Flagged
|
Public Assessment | DanielRenfro | 2017-02-28 13:45:40 CST | This annotation has been flagged because it has been edited since last assessment
Qualifier |
GO ID |
GO term name |
Reference |
Evidence Code |
with/from |
Aspect |
Notes |
Status
|
|
GO:2000627 |
positive regulation of miRNA catabolic process |
PMID:18951094 |
IDA: Inferred from Direct Assay |
|
P |
Fig. 4e shows a quicker decay of target species after uridylation by overexpressed human lin28b; pre-let-7a-1 is nonuridylated while up-let-7a-1 is the form uridylated by lin28b. Called Lin28b or collectively as Lin28 in the paper. |
complete CACAO 12255
| on HUMAN:LN28B
| Flagged
|
Public Assessment | DanielRenfro | 2017-02-28 13:44:26 CST | This annotation has been flagged because it has been edited since last assessment
Qualifier |
GO ID |
GO term name |
Reference |
Evidence Code |
with/from |
Aspect |
Notes |
Status
|
|
GO:2000627 |
miRNA catabolic process |
PMID:18951094 |
IDA: Inferred from Direct Assay |
|
P |
Fig. 4e shows a quicker decay of target species after uridylation by overexpressed human lin28b; pre-let-7a-1 is nonuridylated while up-let-7a-1 is the form uridylated by lin28b. Called Lin28b or collectively as Lin28 in the paper. |
complete CACAO 12255
| on HUMAN:LN28B
| Flagged
|
Private Assessment | Suzialeksander | 2017-02-24 15:42:23 CST | You need to be an instructor to view these notes. | Requires Changes
✔ Publication ✔ Qualifier ✗ Go term ✗ Evidence ✔ With/From ✗ Notes
|