HUMAN:LIF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LIF (synonyms: HILDA)
Protein Name(s)	Leukemia inhibitory factor LIF Differentiation-stimulating factor D factor Melanoma-derived LPL inhibitor MLPLI
External Links
UniProt	P15018
EMBL	X13967 M27053 M27052 AC004264 M63420 CN409468 AK315310 CH471095 BC069540 BC093733 BC093735 J03261
CCDS	CCDS13872.1 CCDS58799.1
PIR	B36282
RefSeq	NP_001244064.1 NP_002300.1 XP_006724303.1 XP_011528474.1
UniGene	Hs.2250
PDB	1EMR 1PVH 2Q7N
PDBsum	1EMR 1PVH 2Q7N
ProteinModelPortal	P15018
SMR	P15018
BioGrid	110164
DIP	DIP-5769N
IntAct	P15018
MINT	MINT-1352030
STRING	9606.ENSP00000249075
BioMuta	LIF
DMDM	126279
PaxDb	P15018
PRIDE	P15018
Ensembl	ENST00000249075 ENST00000403987
GeneID	3976
KEGG	hsa:3976
UCSC	uc003agz.3
CTD	3976
GeneCards	LIF
HGNC	HGNC:6596
HPA	CAB025985 HPA018844
MIM	159540
neXtProt	NX_P15018
PharmGKB	PA30370
eggNOG	ENOG410ITBQ ENOG410YVPP
GeneTree	ENSGT00390000000059
HOGENOM	HOG000059647
HOVERGEN	HBG006267
InParanoid	P15018
KO	K05419
OMA	KYHVAHV
OrthoDB	EOG7JX359
PhylomeDB	P15018
TreeFam	TF336245
SignaLink	P15018
EvolutionaryTrace	P15018
GeneWiki	Leukemia_inhibitory_factor
GenomeRNAi	3976
NextBio	15584
PMAP-CutDB	P15018
PRO	PR:P15018
Proteomes	UP000005640
Bgee	P15018
CleanEx	HS_LIF
Genevisible	P15018
GO	GO:0005737 GO:0005615 GO:0005125 GO:0008083 GO:0005146 GO:0005102 GO:0001135 GO:0048708 GO:0001974 GO:0046697 GO:0007566 GO:0006955 GO:0048861 GO:0048286 GO:0060463 GO:0060426 GO:0007275 GO:0048644 GO:0016525 GO:0008285 GO:0070373 GO:0046888 GO:0045835 GO:0048666 GO:0031100 GO:0048711 GO:0008284 GO:0051461 GO:1901676 GO:0045651 GO:0043410 GO:0072108 GO:0010976 GO:0033138 GO:0033141 GO:0050731 GO:1900182 GO:0045944 GO:0042511 GO:0042517 GO:0072307 GO:1903025 GO:0060041 GO:0060708 GO:0048863 GO:0019827 GO:0060290 GO:0060707 GO:0042503
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR003624 IPR001581 IPR019827
PANTHER	PTHR10633
Pfam	PF01291
PRINTS	PR01883
SMART	SM00080
SUPFAM	SSF47266
PROSITE	PS00590

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:26723254^[1]	ECO:0000315			P	Figs 2,3	complete CACAO 11257
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:26723254^[1]	ECO:0000314			P	Figure 1 shows increased integrin expression (higher levels of integrin mRNA)	complete CACAO 11522
	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:26723254^[1]	ECO:0000315			P	As shown in Fig. 2B, LIF increased the adhesion of the human trophectoderm-derived JAr cells to endometrial Ishikawa cells. On the contrary, hLA diminished the adhesion of JAr cells to LIF-stimulated Ishikawa cells. These results suggest that the enhancement of integrin αV, β3, and β5 by LIF might be associated with the adhesion of trophblast to endometrium for embryo implantation. Figure 2A shows adhesion is dependent on integrins. (hLa inhibits LIF, hence IMP) Figure 3 uses antibodies to neutralize the integrins.	complete CACAO 11523
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	PMID:26723254^[1]	ECO:0000315			P	Figure 2A Treatment of hLA (inhibitor of LIF) clearly resulted in the reduction of ITGAV, ITGB3 and ITGB5 expression levels induced by LIF in the Ishikawa cells	complete CACAO 11524
involved_in	GO:1901676	positive regulation of histone H3-K27 acetylation	PMID:22783022^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:22783022^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	PMID:20624457^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072108	positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	PMID:20624457^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048861	leukemia inhibitory factor signaling pathway	PMID:12643274^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048861	leukemia inhibitory factor signaling pathway	PMID:8999038^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22783022^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20624457^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:20624457^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:20624457^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8999038^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:12643274^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:8999038^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12643274^[4]	ECO:0000305	curator inference used in manual assertion	GO:0008083	C	Seeded From UniProt	complete
enables	GO:0005146	leukemia inhibitory factor receptor binding	PMID:8999038^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P40189	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:8999038^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P42702	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:22783022^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048861	leukemia inhibitory factor signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067074 UniProtKB:P15018	P	Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96787 PANTHER:PTN000067074	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96787 PANTHER:PTN000067074 UniProtKB:P15018	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96787 PANTHER:PTN000067074 UniProtKB:P15018	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067074 RGD:620865	C	Seeded From UniProt	complete
enables	GO:0005146	leukemia inhibitory factor receptor binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000067074 RGD:620865 UniProtKB:P15018	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96787 PANTHER:PTN000067074 UniProtKB:P15018	F	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:7508917^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046888	negative regulation of hormone secretion	PMID:7867561^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:7508917^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045651	positive regulation of macrophage differentiation	PMID:7957045^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:7508917^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:7508917^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7957045^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:7957045^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005146	leukemia inhibitory factor receptor binding	PMID:7957045^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:7957045^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0060708	spongiotrophoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0060707	trophoblast giant cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0060463	lung lobe morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0060426	lung vasculature development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0060135	maternal process involved in female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0048863	stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0048711	positive regulation of astrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0048644	muscle organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0045835	negative regulation of meiotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	F	Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	F	Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09056 ensembl:ENSMUSP00000067066	P	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001581 InterPro:IPR019827	F	Seeded From UniProt	complete
enables	GO:0005146	leukemia inhibitory factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003624	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001581 InterPro:IPR003624 InterPro:IPR019827	C	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001581 InterPro:IPR019827	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:3143918^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:3143918^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-6783783 Reactome:R-HSA-6783589	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6789615 Reactome:R-HSA-6784160 Reactome:R-HSA-6783681 Reactome:R-HSA-6783524	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Chung, TW et al. (2016) Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells. Biochem. Biophys. Res. Commun. 469 936-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Icardi, L et al. (2012) The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 109 12058-63 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wang, H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell. Signal. 22 1717-26 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Schuster, B et al. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 9528-35 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Mosley, B et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271 32635-43 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Yin, T & Yang, YC (1994) Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J. Biol. Chem. 269 3731-8 PubMed GONUTS page
↑ Yamaguchi, M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136 1072-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Hilton, DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13 4765-75 PubMed GONUTS page
↑ ^10.0 ^10.1 Moreau, JF et al. (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336 690-2 PubMed GONUTS page

[PMID:26723254-1] 1.0 ^1.1 ^1.2 ^1.3 Chung, TW et al. (2016) Integrin αVβ3 and αVβ5 are required for leukemia inhibitory factor-mediated the adhesion of trophoblast cells to the endometrial cells. Biochem. Biophys. Res. Commun. 469 936-40 PubMed GONUTS page

[PMID:22783022-2] 2.0 ^2.1 ^2.2 ^2.3 Icardi, L et al. (2012) The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc. Natl. Acad. Sci. U.S.A. 109 12058-63 PubMed GONUTS page

[PMID:20624457-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Wang, H et al. (2010) STAT1 activation regulates proliferation and differentiation of renal progenitors. Cell. Signal. 22 1717-26 PubMed GONUTS page

[PMID:12643274-4] 4.0 ^4.1 ^4.2 Schuster, B et al. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 9528-35 PubMed GONUTS page

[PMID:8999038-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Mosley, B et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271 32635-43 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7508917-7] 7.0 ^7.1 ^7.2 ^7.3 Yin, T & Yang, YC (1994) Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells. J. Biol. Chem. 269 3731-8 PubMed GONUTS page

[PMID:7867561-8] Yamaguchi, M et al. (1995) Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer. Endocrinology 136 1072-8 PubMed GONUTS page

[PMID:7957045-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Hilton, DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13 4765-75 PubMed GONUTS page

[PMID:3143918-10] 10.0 ^10.1 Moreau, JF et al. (1988) Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells. Nature 336 690-2 PubMed GONUTS page

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HUMAN:LIF

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