HUMAN:LEPR

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LEPR (synonyms: DB, OBR)
Protein Name(s)	Leptin receptor LEP-R HuB219 OB receptor OB-R
External Links
UniProt	P48357
EMBL	U43168 U66495 U66496 U66497 U52912 U52913 U52914 U59263 U59248 U59249 U59250 U59252 U59253 U59254 U59255 U59256 U59257 U59258 U59259 U59260 U59261 U59262 U50748
CCDS	CCDS30740.1 CCDS30741.1 CCDS55604.1 CCDS631.1
RefSeq	NP_001003679.1 NP_001003680.1 NP_001185616.1 NP_001185617.1 NP_001185618.1 NP_002294.2
UniGene	Hs.23581 Hs.723178
PDB	3V6O
PDBsum	3V6O
ProteinModelPortal	P48357
SMR	P48357
BioGrid	110144
DIP	DIP-6117N
IntAct	P48357
MINT	MINT-1387953
STRING	9606.ENSP00000330393
ChEMBL	CHEMBL5913
GuidetoPHARMACOLOGY	1712
PhosphoSite	P48357
DMDM	116242617
MaxQB	P48357
PaxDb	P48357
PRIDE	P48357
DNASU	3953
Ensembl	ENST00000344610 ENST00000349533 ENST00000371058 ENST00000371059 ENST00000371060 ENST00000616738
GeneID	3953
KEGG	hsa:3953
UCSC	uc001dcg.3 uc001dch.3 uc001dci.3 uc021ool.1
CTD	3953
GeneCards	GC01P065886
HGNC	HGNC:6554
HPA	HPA030899
MIM	601007 614963
neXtProt	NX_P48357
Orphanet	179494
PharmGKB	PA229
eggNOG	NOG29456
GeneTree	ENSGT00730000111209
HOVERGEN	HBG000140
InParanoid	P48357
KO	K05062
OMA	SWAQGLN
OrthoDB	EOG7034GB
PhylomeDB	P48357
TreeFam	TF106501
Reactome	REACT_169118
SignaLink	P48357
GeneWiki	Leptin_receptor
GenomeRNAi	3953
NextBio	15505
PRO	PR:P48357
Proteomes	UP000005640
Bgee	P48357
CleanEx	HS_LEPR
ExpressionAtlas	P48357
Genevestigator	P48357
GO	GO:0005576 GO:0016021 GO:0005886 GO:0043235 GO:0004896 GO:0042802 GO:0004888 GO:0007166 GO:0008203 GO:0006112 GO:0007275 GO:0045721 GO:0051346
Gene3D	2.60.40.10
InterPro	IPR003961 IPR003529 IPR003531 IPR007110 IPR013783 IPR010457 IPR015752
PANTHER	PTHR23036:SF11
Pfam	PF06328
SMART	SM00060
SUPFAM	SSF49265
PROSITE	PS50853 PS01353

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:11003997^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21771332^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0098868	bone growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
enables	GO:0038021	leptin receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	F	Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48356	P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:25060689^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002745476 UniProtKB:P10912 UniProtKB:P42702 UniProtKB:P48357 UniProtKB:Q5VWK5	C	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104993 PANTHER:PTN002346635 RGD:3001	P	Seeded From UniProt	complete
enables	GO:0019955	cytokine binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104579 MGI:MGI:1330819 MGI:MGI:2180511 PANTHER:PTN002745476 RGD:1303100 RGD:621431 UniProtKB:O75462 UniProtKB:P26992	F	Seeded From UniProt	complete
enables	GO:0017046	peptide hormone binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002346635 RGD:3001	F	Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104579 MGI:MGI:1270861 MGI:MGI:1330819 MGI:MGI:1889506 MGI:MGI:2180511 MGI:MGI:96551 MGI:MGI:96560 PANTHER:PTN002745476	C	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002745476 UniProtKB:Q14213 UniProtKB:Q9HC73	F	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16116438^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P48357	F	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0098868	bone growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0097009	energy homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0060259	regulation of feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0051346	negative regulation of hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0044321	response to leptin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
enables	GO:0038021	leptin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	F	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0014009	glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48356 ensembl:ENSMUSP00000037385	P	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003529 InterPro:IPR003531	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003529 InterPro:IPR003531	C	Seeded From UniProt	complete
enables	GO:0038021	leptin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015752	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20347812^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P48357-1	F	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20347812^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P48357-3	F	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:9537324^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:9537324^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	PMID:9537324^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	PMID:9537324^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Masaki, T et al. (2000) Impaired response of UCP family to cold exposure in diabetic (db/db) mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 R1305-9 PubMed GONUTS page
↑ Ferla, R et al. (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11 303 PubMed GONUTS page
↑ Cassano, S et al. (2014) Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metab. Clin. Exp. 63 1272-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Brown, RJ et al. (2005) Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat. Struct. Mol. Biol. 12 814-21 PubMed GONUTS page
↑ ^7.0 ^7.1 Bacart, J et al. (2010) Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS Lett. 584 2213-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Clément, K et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392 398-401 PubMed GONUTS page

[PMID:11003997-1] Masaki, T et al. (2000) Impaired response of UCP family to cold exposure in diabetic (db/db) mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279 R1305-9 PubMed GONUTS page

[PMID:21771332-2] Ferla, R et al. (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11 303 PubMed GONUTS page

[PMID:25060689-3] Cassano, S et al. (2014) Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metab. Clin. Exp. 63 1272-9 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23382219-5] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:16116438-6] Brown, RJ et al. (2005) Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat. Struct. Mol. Biol. 12 814-21 PubMed GONUTS page

[PMID:20347812-7] 7.0 ^7.1 Bacart, J et al. (2010) Evidence for leptin receptor isoforms heteromerization at the cell surface. FEBS Lett. 584 2213-7 PubMed GONUTS page

[PMID:9537324-8] 8.0 ^8.1 ^8.2 ^8.3 Clément, K et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392 398-401 PubMed GONUTS page

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HUMAN:LEPR

Contents

Annotations

Notes

References

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