HUMAN:LEP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LEP (synonyms: OB, OBS)
Protein Name(s)	Leptin Obese protein Obesity factor
External Links
UniProt	P41159
EMBL	U18915 D49487 U43653 U43415 D63710 D63519 AF008123 AY996373 BC060830 BC069452 BC069527
CCDS	CCDS5800.1
PIR	A38952 I53166
RefSeq	NP_000221.1 XP_005250397.1
UniGene	Hs.194236
PDB	1AX8
PDBsum	1AX8
ProteinModelPortal	P41159
BioGrid	110143
DIP	DIP-6116N
STRING	9606.ENSP00000312652
PhosphoSite	P41159
PaxDb	P41159
PeptideAtlas	P41159
PRIDE	P41159
DNASU	3952
Ensembl	ENST00000308868
GeneID	3952
KEGG	hsa:3952
UCSC	uc003vml.2
CTD	3952
GeneCards	GC07P127881
HGNC	HGNC:6553
HPA	CAB010490 CAB016730 HPA030721
MIM	164160 614962
neXtProt	NX_P41159
Orphanet	66628
PharmGKB	PA228
eggNOG	NOG45133
GeneTree	ENSGT00390000011772
HOGENOM	HOG000252923
HOVERGEN	HBG007860
InParanoid	P41159
KO	K05424
OMA	RINDISH
OrthoDB	EOG77Q4Z3
PhylomeDB	P41159
TreeFam	TF105086
Reactome	REACT_169118 REACT_19189 REACT_24019 REACT_27161
SignaLink	P41159
EvolutionaryTrace	P41159
GeneWiki	Leptin
GenomeRNAi	3952
NextBio	15501
PRO	PR:P41159
Proteomes	UP000005640
Bgee	P41159
CleanEx	HS_LEP
ExpressionAtlas	P41159
Genevestigator	P41159
GO	GO:0005737 GO:0005576 GO:0005615 GO:0060612 GO:0008343 GO:0008206 GO:0035630 GO:0071298 GO:0071300 GO:0021954 GO:0008203 GO:0007623 GO:0042755 GO:0006112 GO:0006635 GO:0007565 GO:0042593 GO:0006006 GO:0006114 GO:0042445 GO:0030073 GO:0033210 GO:0050901 GO:0043066 GO:0032099 GO:0061037 GO:0070093 GO:2000486 GO:0000122 GO:0045906 GO:0001542 GO:0001890 GO:0008284 GO:0001819 GO:0048639 GO:0046881 GO:2000491 GO:0046628 GO:0043270 GO:0033686 GO:0043410 GO:0045639 GO:2000366 GO:0042517 GO:0008217 GO:0045598 GO:0006111 GO:0050796 GO:0030300 GO:0060587 GO:0050810 GO:0002021 GO:0001666 GO:0032868 GO:0033197 GO:0007260
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000065
PANTHER	PTHR11724
Pfam	PF02024
PIRSF	PIRSF001837
PRINTS	PR00495
ProDom	PD005698
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0060612	adipose tissue development	PMID:24505549^[1]	ECO:0000314			P	Table 1 shows that adipose tissue increases significantly in breast cancer patients.	complete CACAO 9473
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27986616^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:19910644^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:21771332^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0098868	bone growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0072606	interleukin-8 secretion	PMID:19688109^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0072604	interleukin-6 secretion	PMID:19688109^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032310	prostaglandin secretion	PMID:19688109^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900015	regulation of cytokine production involved in inflammatory response	PMID:19688109^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	PMID:15899045^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0001936	regulation of endothelial cell proliferation	PMID:11460888^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045765	regulation of angiogenesis	PMID:11460888^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:24340098^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990051	activation of protein kinase C activity	PMID:24340098^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:24340098^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	PMID:24340098^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050892	intestinal absorption	PMID:24340098^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046325	negative regulation of glucose import	PMID:24340098^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	PMID:8589726^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50596	P	Seeded From UniProt	complete
involved_in	GO:0032817	regulation of natural killer cell proliferation	PMID:12504075^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042269	regulation of natural killer cell mediated cytotoxicity	PMID:12504075^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032814	regulation of natural killer cell activation	PMID:12504075^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	PMID:17344214^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:17344214^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:17344214^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:25060689^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:25060689^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:25060689^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50596	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50596	P	Seeded From UniProt	complete
involved_in	GO:0048639	positive regulation of developmental growth	PMID:17957153^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	PMID:17957153^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
involved_in	GO:0008343	adult feeding behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41160	C	Seeded From UniProt	complete
involved_in	GO:1990051	activation of protein kinase C activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:1900745	positive regulation of p38MAPK cascade	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	F	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 UniProtKB:G8BLB4 UniProtKB:P50595	P	Seeded From UniProt	complete
involved_in	GO:0032008	positive regulation of TOR signaling	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:P41159	P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963	P	Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104663 PANTHER:PTN001711963 RGD:3000 UniProtKB:G8BLB4 UniProtKB:O42164 UniProtKB:P50595	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001711963 RGD:3000	F	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P	Seeded From UniProt	complete
involved_in	GO:1900180	regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0098868	bone growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0090335	regulation of brown fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0070093	negative regulation of glucagon secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0060612	adipose tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0051541	elastin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0050999	regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0050810	regulation of steroid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0046890	regulation of lipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0046850	regulation of bone remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0045598	regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0042755	eating behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0042445	hormone metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0035904	aorta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0032635	interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0032615	interleukin-12 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0032099	negative regulation of appetite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0030300	regulation of intestinal cholesterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0021954	central nervous system neuron development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0019953	sexual reproduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0019222	regulation of metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0008343	adult feeding behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0008206	bile acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0008203	cholesterol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0006635	fatty acid beta-oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0006111	regulation of gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	C	Seeded From UniProt	complete
involved_in	GO:0002021	response to dietary excess	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41160 ensembl:ENSMUSP00000067046	P	Seeded From UniProt	complete
involved_in	GO:2000491	positive regulation of hepatic stellate cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:2000486	negative regulation of glutamine transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:1904651	positive regulation of fat cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0071298	cellular response to L-ascorbic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0061037	negative regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0060587	regulation of lipoprotein lipid oxidation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	F	Seeded From UniProt	complete
involved_in	GO:0050901	leukocyte tethering or rolling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0046881	positive regulation of follicle-stimulating hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0043270	positive regulation of ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0035630	bone mineralization involved in bone maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0033686	positive regulation of luteinizing hormone secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0033210	leptin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0010888	negative regulation of lipid storage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0009892	negative regulation of metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0009062	fatty acid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0008217	regulation of blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0007584	response to nutrient	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0006114	glycerol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	C	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	F	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	F	Seeded From UniProt	complete
involved_in	GO:0003300	cardiac muscle hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0002021	response to dietary excess	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0001819	positive regulation of cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
involved_in	GO:0001542	ovulation from ovarian follicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50596 ensembl:ENSRNOP00000066184	P	Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	C	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000065	P	Seeded From UniProt	complete
involved_in	GO:0006112	energy reserve metabolic process	PMID:9537324^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9054940^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-1183003	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nalabolu, MR et al. (2014) Adiponectin and leptin molecular actions and clinical significance in breast cancer. Int J Hematol Oncol Stem Cell Res 8 31-40 PubMed GONUTS page
↑ Martins, FF et al. (2017) Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann. Anat. 210 44-51 PubMed GONUTS page
↑ Heida, NM et al. (2010) Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity. Arterioscler. Thromb. Vasc. Biol. 30 200-6 PubMed GONUTS page
↑ Ferla, R et al. (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11 303 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Vuolteenaho, K et al. (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm. 2009 345838 PubMed GONUTS page
↑ Otero, M et al. (2005) Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res. Ther. 7 R581-91 PubMed GONUTS page
↑ ^7.0 ^7.1 Park, HY et al. (2001) Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp. Mol. Med. 33 95-102 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 El-Zein, O & Kreydiyyeh, SI (2013) Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK. PLoS ONE 8 e83360 PubMed GONUTS page
↑ Chehab, FF et al. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12 318-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Zhao, Y et al. (2003) Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys. Res. Commun. 300 247-52 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Saxena, NK et al. (2007) leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J. Biol. Chem. 282 13316-25 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Cassano, S et al. (2014) Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metab. Clin. Exp. 63 1272-9 PubMed GONUTS page
↑ ^13.0 ^13.1 James, RJ et al. (2007) Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations. Pediatr. Res. 62 695-9 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Clément, K et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392 398-401 PubMed GONUTS page
↑ Comuzzie, AG et al. (1997) A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat. Genet. 15 273-6 PubMed GONUTS page

[PMID:24505549-1] Nalabolu, MR et al. (2014) Adiponectin and leptin molecular actions and clinical significance in breast cancer. Int J Hematol Oncol Stem Cell Res 8 31-40 PubMed GONUTS page

[PMID:27986616-2] Martins, FF et al. (2017) Thermogenesis, fatty acid synthesis with oxidation, and inflammation in the brown adipose tissue of ob/ob (-/-) mice. Ann. Anat. 210 44-51 PubMed GONUTS page

[PMID:19910644-3] Heida, NM et al. (2010) Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity. Arterioscler. Thromb. Vasc. Biol. 30 200-6 PubMed GONUTS page

[PMID:21771332-4] Ferla, R et al. (2011) Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects. BMC Cancer 11 303 PubMed GONUTS page

[PMID:19688109-5] 5.0 ^5.1 ^5.2 ^5.3 Vuolteenaho, K et al. (2009) Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediators Inflamm. 2009 345838 PubMed GONUTS page

[PMID:15899045-6] Otero, M et al. (2005) Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1. Arthritis Res. Ther. 7 R581-91 PubMed GONUTS page

[PMID:11460888-7] 7.0 ^7.1 Park, HY et al. (2001) Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp. Mol. Med. 33 95-102 PubMed GONUTS page

[PMID:24340098-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 El-Zein, O & Kreydiyyeh, SI (2013) Leptin inhibits glucose intestinal absorption via PKC, p38MAPK, PI3K and MEK/ERK. PLoS ONE 8 e83360 PubMed GONUTS page

[PMID:8589726-9] Chehab, FF et al. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12 318-20 PubMed GONUTS page

[PMID:12504075-10] 10.0 ^10.1 ^10.2 Zhao, Y et al. (2003) Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochem. Biophys. Res. Commun. 300 247-52 PubMed GONUTS page

[PMID:17344214-11] 11.0 ^11.1 ^11.2 Saxena, NK et al. (2007) leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J. Biol. Chem. 282 13316-25 PubMed GONUTS page

[PMID:25060689-12] 12.0 ^12.1 ^12.2 Cassano, S et al. (2014) Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metab. Clin. Exp. 63 1272-9 PubMed GONUTS page

[PMID:17957153-13] 13.0 ^13.1 James, RJ et al. (2007) Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations. Pediatr. Res. 62 695-9 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9537324-15] Clément, K et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392 398-401 PubMed GONUTS page

[PMID:9054940-16] Comuzzie, AG et al. (1997) A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat. Genet. 15 273-6 PubMed GONUTS page

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