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HUMAN:LEG1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LGALS1
Protein Name(s) Galectin-1

Gal-1 14 kDa laminin-binding protein HLBP14 14 kDa lectin Beta-galactoside-binding lectin L-14-I Galaptin HBL HPL Lactose-binding lectin 1 Lectin galactoside-binding soluble 1 Putative MAPK-activating protein PM12 S-Lac lectin 1

External Links
UniProt P09382
EMBL X14829
J04456
X15256
EU363770
M57678
AB097036
CR456511
AK312161
BT006775
Z83844
CH471095
BC001693
BC020675
CCDS CCDS13954.1
PIR A37134
RefSeq NP_002296.1
UniGene Hs.445351
PDB 1GZW
1W6M
1W6N
1W6O
1W6P
1W6Q
2KM2
2ZKN
3OY8
3OYW
3T2T
3W58
3W59
PDBsum 1GZW
1W6M
1W6N
1W6O
1W6P
1W6Q
2KM2
2ZKN
3OY8
3OYW
3T2T
3W58
3W59
ProteinModelPortal P09382
SMR P09382
BioGrid 110147
DIP DIP-46153N
IntAct P09382
MINT MINT-3306493
STRING 9606.ENSP00000215909
BindingDB P09382
ChEMBL CHEMBL4915
PhosphoSite P09382
DMDM 126155
DOSAC-COBS-2DPAGE P09382
REPRODUCTION-2DPAGE IPI00219219
P09382
SWISS-2DPAGE P09382
UCD-2DPAGE P09382
MaxQB P09382
PaxDb P09382
PeptideAtlas P09382
PRIDE P09382
DNASU 3956
Ensembl ENST00000215909
GeneID 3956
KEGG hsa:3956
UCSC uc003atn.3
CTD 3956
GeneCards GC22P038071
HGNC HGNC:6561
HPA CAB002157
HPA000646
HPA000687
HPA001130
MIM 150570
neXtProt NX_P09382
PharmGKB PA30337
eggNOG NOG279327
GeneTree ENSGT00440000034263
HOGENOM HOG000059539
HOVERGEN HBG006255
InParanoid P09382
KO K06830
OMA INTIVCN
OrthoDB EOG7NKKN0
PhylomeDB P09382
TreeFam TF315551
ChiTaRS LGALS1
EvolutionaryTrace P09382
GeneWiki Galectin-1
LGALS1
GenomeRNAi 3956
NextBio 15523
PMAP-CutDB P09382
PRO PR:P09382
Proteomes UP000005640
Bgee P09382
CleanEx HS_LGALS1
ExpressionAtlas P09382
Genevestigator P09382
GO GO:0009986
GO:0005737
GO:0005615
GO:0070062
GO:0005622
GO:0005634
GO:0005578
GO:0016936
GO:0030395
GO:0044822
GO:0004871
GO:0006915
GO:0071333
GO:0071407
GO:0033555
GO:0045445
GO:0010812
GO:0010977
GO:0002317
GO:0034120
GO:0043123
GO:0042981
GO:0048678
GO:0042493
GO:0007165
GO:0031295
Gene3D 2.60.120.200
InterPro IPR013320
IPR015535
IPR001079
PANTHER PTHR11346:SF30
Pfam PF00337
SMART SM00908
SM00276
SUPFAM SSF49899
PROSITE PS51304

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0042981

regulation of apoptosis

PMID:21364631[1]

ECO:0000314

P

Jurkat T lymphocytes exposed to gal-1 for 6 h underwent apoptosis as indicated by DNA fragmentation: Figure 1

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:28327460[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002540)|part_of:(CL:0002570)|part_of:(CL:0002551)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)|part_of:(UBERON:0001911)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:27068509[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:23979707[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002543)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

complete

involved_in

GO:0046598

positive regulation of viral entry into host cell

PMID:21670307[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:2001200

positive regulation of dendritic cell differentiation

PMID:16116184[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[10]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005622

intracellular

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:22261194[12]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q49I35

C

part_of:(UBERON:0002084)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:20551380[11]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[13]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501[14]

ECO:0007001

high throughput mutant phenotypic evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071407

cellular response to organic cyclic compound

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

involved_in

GO:0048678

response to axon injury

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

enables

GO:0043236

laminin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

involved_in

GO:0035900

response to isolation stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

involved_in

GO:0034120

positive regulation of erythrocyte aggregation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

enables

GO:0030395

lactose binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

F

Seeded From UniProt

complete

involved_in

GO:0010977

negative regulation of neuron projection development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

involved_in

GO:0010812

negative regulation of cell-substrate adhesion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P11762
ensembl:ENSRNOP00000013538

C

Seeded From UniProt

complete

involved_in

GO:0045445

myoblast differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16045
ensembl:ENSMUSP00000086795

P

Seeded From UniProt

complete

involved_in

GO:0031295

T cell costimulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16045
ensembl:ENSMUSP00000086795

P

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16045
ensembl:ENSMUSP00000086795

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16045
ensembl:ENSMUSP00000086795

C

Seeded From UniProt

complete

involved_in

GO:0002317

plasma cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P16045
ensembl:ENSMUSP00000086795

P

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001079

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:1713454[15]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

PMID:16130169[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16130169[16]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8952289

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0430

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Brandt, B et al. (2010) Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. Cell Death Dis 1 e23 PubMed GONUTS page
  2. Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
  3. Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  4. 4.0 4.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  5. Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  6. Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
  7. Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  8. Bi, S et al. (2011) Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc. Natl. Acad. Sci. U.S.A. 108 10650-5 PubMed GONUTS page
  9. Dai, SY et al. (2005) Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 175 2974-81 PubMed GONUTS page
  10. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  11. 11.0 11.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  12. Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
  13. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  14. Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
  15. Goldstone, SD & Lavin, MF (1991) Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death. Biochem. Biophys. Res. Commun. 178 746-50 PubMed GONUTS page
  16. 16.0 16.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page