HUMAN:LEG1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LGALS1
Protein Name(s)	Galectin-1 Gal-1 14 kDa laminin-binding protein HLBP14 14 kDa lectin Beta-galactoside-binding lectin L-14-I Galaptin HBL HPL Lactose-binding lectin 1 Lectin galactoside-binding soluble 1 Putative MAPK-activating protein PM12 S-Lac lectin 1
External Links
UniProt	P09382
EMBL	X14829 J04456 X15256 EU363770 M57678 AB097036 CR456511 AK312161 BT006775 Z83844 CH471095 BC001693 BC020675
CCDS	CCDS13954.1
PIR	A37134
RefSeq	NP_002296.1
UniGene	Hs.445351
PDB	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59
PDBsum	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59
ProteinModelPortal	P09382
SMR	P09382
BioGrid	110147
DIP	DIP-46153N
IntAct	P09382
MINT	MINT-3306493
STRING	9606.ENSP00000215909
BindingDB	P09382
ChEMBL	CHEMBL4915
PhosphoSite	P09382
DMDM	126155
DOSAC-COBS-2DPAGE	P09382
REPRODUCTION-2DPAGE	IPI00219219 P09382
SWISS-2DPAGE	P09382
UCD-2DPAGE	P09382
MaxQB	P09382
PaxDb	P09382
PeptideAtlas	P09382
PRIDE	P09382
DNASU	3956
Ensembl	ENST00000215909
GeneID	3956
KEGG	hsa:3956
UCSC	uc003atn.3
CTD	3956
GeneCards	GC22P038071
HGNC	HGNC:6561
HPA	CAB002157 HPA000646 HPA000687 HPA001130
MIM	150570
neXtProt	NX_P09382
PharmGKB	PA30337
eggNOG	NOG279327
GeneTree	ENSGT00440000034263
HOGENOM	HOG000059539
HOVERGEN	HBG006255
InParanoid	P09382
KO	K06830
OMA	INTIVCN
OrthoDB	EOG7NKKN0
PhylomeDB	P09382
TreeFam	TF315551
ChiTaRS	LGALS1
EvolutionaryTrace	P09382
GeneWiki	Galectin-1 LGALS1
GenomeRNAi	3956
NextBio	15523
PMAP-CutDB	P09382
PRO	PR:P09382
Proteomes	UP000005640
Bgee	P09382
CleanEx	HS_LGALS1
ExpressionAtlas	P09382
Genevestigator	P09382
GO	GO:0009986 GO:0005737 GO:0005615 GO:0070062 GO:0005622 GO:0005634 GO:0005578 GO:0016936 GO:0030395 GO:0044822 GO:0004871 GO:0006915 GO:0071333 GO:0071407 GO:0033555 GO:0045445 GO:0010812 GO:0010977 GO:0002317 GO:0034120 GO:0043123 GO:0042981 GO:0048678 GO:0042493 GO:0007165 GO:0031295
Gene3D	2.60.120.200
InterPro	IPR013320 IPR015535 IPR001079
PANTHER	PTHR11346:SF30
Pfam	PF00337
SMART	SM00908 SM00276
SUPFAM	SSF49899
PROSITE	PS51304

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042981	regulation of apoptosis	PMID:21364631^[1]	ECO:0000314			P		Jurkat T lymphocytes exposed to gal-1 for 6 h underwent apoptosis as indicated by DNA fragmentation: Figure 1	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002540)\|part_of:(CL:0002570)\|part_of:(CL:0002551)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:28675934^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0003688)\|part_of:(UBERON:0001911)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0002107)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:25037231^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001155)	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:27068509^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:23979707^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002543)	Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	PMID:27559042^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0006618) part_of:(UBERON:0002302)	Seeded From UniProt	complete
involved_in	GO:0046598	positive regulation of viral entry into host cell	PMID:21670307^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:2001200	positive regulation of dendritic cell differentiation	PMID:16116184^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005622	intracellular	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:20551380^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:22261194^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q49I35	C	part_of:(UBERON:0002084)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20551380^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001496)	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:12761501^[14]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
involved_in	GO:0048678	response to axon injury	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
enables	GO:0043236	laminin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
involved_in	GO:0035900	response to isolation stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
involved_in	GO:0034120	positive regulation of erythrocyte aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
enables	GO:0030395	lactose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11762 ensembl:ENSRNOP00000013538	C		Seeded From UniProt	complete
involved_in	GO:0045445	myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16045 ensembl:ENSMUSP00000086795	P		Seeded From UniProt	complete
involved_in	GO:0031295	T cell costimulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16045 ensembl:ENSMUSP00000086795	P		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16045 ensembl:ENSMUSP00000086795	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16045 ensembl:ENSMUSP00000086795	C		Seeded From UniProt	complete
involved_in	GO:0002317	plasma cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P16045 ensembl:ENSMUSP00000086795	P		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001079	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:1713454^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:16130169^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16130169^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Brandt, B et al. (2010) Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. Cell Death Dis 1 e23 PubMed GONUTS page
↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
↑ ^4.0 ^4.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
↑ Bi, S et al. (2011) Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc. Natl. Acad. Sci. U.S.A. 108 10650-5 PubMed GONUTS page
↑ Dai, SY et al. (2005) Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 175 2974-81 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^11.0 ^11.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
↑ Goldstone, SD & Lavin, MF (1991) Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death. Biochem. Biophys. Res. Commun. 178 746-50 PubMed GONUTS page
↑ ^16.0 ^16.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

[PMID:21364631-1] Brandt, B et al. (2010) Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death. Cell Death Dis 1 e23 PubMed GONUTS page

[PMID:28327460-2] Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:28675934-3] Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page

[PMID:25037231-4] 4.0 ^4.1 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page

[PMID:27068509-5] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:23979707-6] Zanivan, S et al. (2013) SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers. Mol. Cell Proteomics 12 3599-611 PubMed GONUTS page

[PMID:27559042-7] Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page

[PMID:21670307-8] Bi, S et al. (2011) Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. Proc. Natl. Acad. Sci. U.S.A. 108 10650-5 PubMed GONUTS page

[PMID:16116184-9] Dai, SY et al. (2005) Galectin-9 induces maturation of human monocyte-derived dendritic cells. J. Immunol. 175 2974-81 PubMed GONUTS page

[PMID:23533145-10] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:20551380-11] 11.0 ^11.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page

[PMID:22261194-12] Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page

[PMID:22658674-13] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:12761501-14] Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page

[PMID:1713454-15] Goldstone, SD & Lavin, MF (1991) Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death. Biochem. Biophys. Res. Commun. 178 746-50 PubMed GONUTS page

[PMID:16130169-16] 16.0 ^16.1 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

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HUMAN:LEG1

Contents

Annotations

Notes

References

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