HUMAN:KS6B1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	RPS6KB1 (synonyms: STK14A)
Protein Name(s)	Ribosomal protein S6 kinase beta-1 S6K-beta-1 S6K1 70 kDa ribosomal protein S6 kinase 1 P70S6K1 p70-S6K 1 Ribosomal protein S6 kinase I Serine/threonine-protein kinase 14A p70 ribosomal S6 kinase alpha p70 S6 kinase alpha p70 S6K-alpha p70 S6KA
External Links
UniProt	P23443
EMBL	M60724 M60725 AK297147 AK300202 AK312875 AC004686 CH471109 BC053365
CCDS	CCDS11621.1 CCDS62271.1 CCDS62272.1 CCDS62273.1
PIR	A41687
RefSeq	NP_001258971.1 NP_001258972.1 NP_001258973.1 NP_001258989.1 NP_003152.1
UniGene	Hs.463642
PDB	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46
PDBsum	3A60 3A61 3A62 3WE4 3WF5 3WF6 3WF7 3WF8 3WF9 4L3J 4L3L 4L42 4L43 4L44 4L45 4L46
ProteinModelPortal	P23443
SMR	P23443
BioGrid	112112
DIP	DIP-29986N
IntAct	P23443
MINT	MINT-203709
STRING	9606.ENSP00000225577
BindingDB	P23443
ChEMBL	CHEMBL2111330
GuidetoPHARMACOLOGY	1525
PhosphoSite	P23443
DMDM	54041234
MaxQB	P23443
PaxDb	P23443
PRIDE	P23443
DNASU	6198
Ensembl	ENST00000225577 ENST00000393021 ENST00000406116 ENST00000443572
GeneID	6198
KEGG	hsa:6198
UCSC	uc002ixy.4 uc010ddj.3
CTD	6198
GeneCards	GC17P057970
HGNC	HGNC:10436
HPA	CAB003838 CAB018346 HPA039442
MIM	608938
neXtProt	NX_P23443
PharmGKB	PA34851
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	P23443
KO	K04688
OMA	ANRMPAR
PhylomeDB	P23443
TreeFam	TF313438
BRENDA	2.7.11.1
Reactome	REACT_6754 REACT_6772
SignaLink	B2R779 B4DTG1 F6UYM1 P23443
ChiTaRS	RPS6KB1
EvolutionaryTrace	P23443
GeneWiki	P70-S6_Kinase_1
GenomeRNAi	6198
NextBio	24073
PRO	PR:P23443
Proteomes	UP000005640
Bgee	P23443
CleanEx	HS_RPS6KB1
ExpressionAtlas	P23443
Genevestigator	P23443
GO	GO:0030054 GO:0009986 GO:0005737 GO:0005829 GO:0005741 GO:0005739 GO:0043005 GO:0005634 GO:0048471 GO:0045202 GO:0005524 GO:0042277 GO:0004672 GO:0004712 GO:0004711 GO:0007568 GO:0006915 GO:0016477 GO:0071363 GO:0000082 GO:0007281 GO:0008286 GO:0007616 GO:0043066 GO:2001237 GO:0046627 GO:0048015 GO:0045931 GO:0048633 GO:0014911 GO:0048661 GO:0045727 GO:0045948 GO:0043491 GO:0006468 GO:0046324 GO:0042493 GO:0014878 GO:0045471 GO:0033762 GO:0051384 GO:0009749 GO:0009408 GO:0043201 GO:0032496 GO:0009612 GO:0007584 GO:0033574 GO:0009636 GO:0034612 GO:0009611 GO:0007165 GO:0014732 GO:0003009 GO:0031929
InterPro	IPR000961 IPR011009 IPR017892 IPR000719 IPR017441 IPR016238 IPR002290 IPR008271
Pfam	PF00069 PF00433
PIRSF	PIRSF000605
SMART	SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0031667	response to nutrient levels	PMID:29750193^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:29750193^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:28178239^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:28178239^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044539	long-chain fatty acid import into cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BSK8	P	Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	PMID:17936702^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:18952604^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045948	positive regulation of translational initiation	PMID:16763566^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045931	positive regulation of mitotic cell cycle	PMID:14673156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:18423201^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17936702^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:12150926^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17936702^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:18952604^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:17936702^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:14673156^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045948	positive regulation of translational initiation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000682933 UniProtKB:P23443 UniProtKB:Q9UBS0	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920336 PANTHER:PTN000682065 UniProtKB:O75582 UniProtKB:O75676	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270849 PANTHER:PTN000682128 UniProtKB:F1MNP4 UniProtKB:Q6TJY3	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020412 FB:FBgn0283472 MGI:MGI:1270849 MGI:MGI:1920336 MGI:MGI:1927343 PANTHER:PTN000682065 RGD:1305144 RGD:620683 TAIR:locus:2077843 TAIR:locus:2077873 UniProtKB:O75582 UniProtKB:O75676 dictyBase:DDB_G0290157	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283473 PANTHER:PTN000682065 PomBase:SPCC24B10.07 SGD:S000000232 TAIR:locus:2077873 UniProtKB:O75582 UniProtKB:P23443 UniProtKB:Q8I4W3	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1920336 PANTHER:PTN000682065 RGD:620683 SGD:S000004710 TAIR:locus:2077843 TAIR:locus:2077873 UniProtKB:O75582 UniProtKB:O75676 UniProtKB:P23443	C	Seeded From UniProt	complete
enables	GO:0004711	ribosomal protein S6 kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001219259 RGD:1305144 RGD:620683	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020412 FB:FBgn0283473 MGI:MGI:1920336 PANTHER:PTN000682065 PomBase:SPCC24B10.07 SGD:S000000232 TAIR:locus:2077873 UniProtKB:O75582 UniProtKB:O75676 UniProtKB:Q8I4W3	F	Seeded From UniProt	complete
enables	GO:0004712	protein serine/threonine/tyrosine kinase activity	PMID:22797923^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR016238 InterPro:IPR017892	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR016238 InterPro:IPR017892	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016238	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19085255^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19085255^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19085255^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19085255^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19085255^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004672	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:1922062^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:1922062^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:9445476^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-165718 Reactome:R-HSA-165777 Reactome:R-HSA-165766 Reactome:R-HSA-165758 Reactome:R-HSA-165726	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-165777 Reactome:R-HSA-165766 Reactome:R-HSA-165758 Reactome:R-HSA-165726	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0771 UniProtKB-SubCell:SL-0261	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nguyen, JT et al. (2018) Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. Sci Adv 4 eaao5838 PubMed GONUTS page
↑ ^2.0 ^2.1 Arif, A et al. (2017) EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature 542 357-361 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Djouder, N et al. (2007) S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol. Cell 28 28-40 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhang, J et al. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J. Biol. Chem. 283 35375-82 PubMed GONUTS page
↑ Shahbazian, D et al. (2006) The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25 2781-91 PubMed GONUTS page
↑ ^6.0 ^6.1 Fingar, DC et al. (2004) mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 24 200-16 PubMed GONUTS page
↑ Ma, XM et al. (2008) SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133 303-13 PubMed GONUTS page
↑ Hara, K et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110 177-89 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Kim, D et al. (2009) Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors 27 12-21 PubMed GONUTS page
↑ ^12.0 ^12.1 Grove, JR et al. (1991) Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol. Cell. Biol. 11 5541-50 PubMed GONUTS page
↑ Pullen, N et al. (1998) Phosphorylation and activation of p70s6k by PDK1. Science 279 707-10 PubMed GONUTS page

[PMID:29750193-1] 1.0 ^1.1 Nguyen, JT et al. (2018) Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration. Sci Adv 4 eaao5838 PubMed GONUTS page

[PMID:28178239-2] 2.0 ^2.1 Arif, A et al. (2017) EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature 542 357-361 PubMed GONUTS page

[PMID:17936702-3] 3.0 ^3.1 ^3.2 ^3.3 Djouder, N et al. (2007) S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Mol. Cell 28 28-40 PubMed GONUTS page

[PMID:18952604-4] 4.0 ^4.1 Zhang, J et al. (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J. Biol. Chem. 283 35375-82 PubMed GONUTS page

[PMID:16763566-5] Shahbazian, D et al. (2006) The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25 2781-91 PubMed GONUTS page

[PMID:14673156-6] 6.0 ^6.1 Fingar, DC et al. (2004) mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol. Cell. Biol. 24 200-16 PubMed GONUTS page

[PMID:18423201-7] Ma, XM et al. (2008) SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133 303-13 PubMed GONUTS page

[PMID:12150926-8] Hara, K et al. (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110 177-89 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22797923-10] Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page

[PMID:19085255-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Kim, D et al. (2009) Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors 27 12-21 PubMed GONUTS page

[PMID:1922062-12] 12.0 ^12.1 Grove, JR et al. (1991) Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol. Cell. Biol. 11 5541-50 PubMed GONUTS page

[PMID:9445476-13] Pullen, N et al. (1998) Phosphorylation and activation of p70s6k by PDK1. Science 279 707-10 PubMed GONUTS page

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HUMAN:KS6B1

Contents

Annotations

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References

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