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HUMAN:KS6A1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RPS6KA1 (synonyms: MAPKAPK1A, RSK1) | |
| Protein Name(s) | Ribosomal protein S6 kinase alpha-1
S6K-alpha-1 90 kDa ribosomal protein S6 kinase 1 p90-RSK 1 p90RSK1 p90S6K MAP kinase-activated protein kinase 1a MAPK-activated protein kinase 1a MAPKAP kinase 1a MAPKAPK-1a Ribosomal S6 kinase 1 RSK-1 | |
| External Links | ||
| UniProt | Q15418 | |
| EMBL | L07597 AK292722 AK299007 AK315730 AL109743 AL627313 AL627313 AL627313 CH471059 BC014966 | |
| CCDS | CCDS284.1 CCDS30649.1 | |
| PIR | I51901 | |
| RefSeq | NP_001006666.1 NP_002944.2 XP_005246024.1 | |
| UniGene | Hs.149957 | |
| PDB | 2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF | |
| PDBsum | 2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF | |
| ProteinModelPortal | Q15418 | |
| SMR | Q15418 | |
| BioGrid | 112109 | |
| DIP | DIP-29987N | |
| IntAct | Q15418 | |
| MINT | MINT-207205 | |
| STRING | 9606.ENSP00000363277 | |
| BindingDB | Q15418 | |
| ChEMBL | CHEMBL2553 | |
| GuidetoPHARMACOLOGY | 1527 | |
| PhosphoSite | Q15418 | |
| DMDM | 20178306 | |
| UCD-2DPAGE | Q15418 | |
| MaxQB | Q15418 | |
| PaxDb | Q15418 | |
| PRIDE | Q15418 | |
| DNASU | 6195 | |
| Ensembl | ENST00000374168 ENST00000526792 ENST00000531382 | |
| GeneID | 6195 | |
| KEGG | hsa:6195 | |
| UCSC | uc001bmr.1 uc001bms.1 | |
| CTD | 6195 | |
| GeneCards | GC01P026856 | |
| HGNC | HGNC:10430 | |
| HPA | CAB003852 HPA007981 | |
| MIM | 601684 | |
| neXtProt | NX_Q15418 | |
| PharmGKB | PA34845 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00770000120454 | |
| HOVERGEN | HBG108317 | |
| InParanoid | Q15418 | |
| KO | K04373 | |
| OMA | PWITQKD | |
| OrthoDB | EOG7B8S38 | |
| PhylomeDB | Q15418 | |
| TreeFam | TF313438 | |
| BRENDA | 2.7.11.1 | |
| Reactome | REACT_120966 REACT_12524 REACT_12599 REACT_169168 REACT_20510 REACT_20568 REACT_22365 | |
| SignaLink | Q15418 | |
| ChiTaRS | RPS6KA1 | |
| EvolutionaryTrace | Q15418 | |
| GeneWiki | RPS6KA1 | |
| GenomeRNAi | 6195 | |
| NextBio | 24057 | |
| PRO | PR:Q15418 | |
| Proteomes | UP000005640 | |
| Bgee | Q15418 | |
| CleanEx | HS_RPS6KA1 | |
| ExpressionAtlas | Q15418 | |
| Genevestigator | Q15418 | |
| GO | GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0005819 GO:0005524 GO:0043027 GO:0000287 GO:0004674 GO:0004712 GO:0007411 GO:0007049 GO:0045087 GO:0002755 GO:0002756 GO:0043066 GO:0043154 GO:0048011 GO:0045597 GO:0030307 GO:2000491 GO:0045944 GO:0043620 GO:0043555 GO:0007165 GO:0051403 GO:0007268 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666 | |
| InterPro | IPR000961 IPR011009 IPR017892 IPR000719 IPR017441 IPR016239 IPR002290 IPR008271 | |
| Pfam | PF00069 PF00433 | |
| PIRSF | PIRSF000606 | |
| SMART | SM00133 SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS51285 PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
F |
Figure 5 |
complete | |||||
|
involved_in |
GO:0072574 |
hepatocyte proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000491 |
positive regulation of hepatic stellate cell activation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043154 |
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043027 |
cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004711 |
ribosomal protein S6 kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262866 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0043027 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045597 |
positive regulation of cell differentiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043620 |
regulation of DNA-templated transcription in response to stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043555 |
regulation of translation in response to stress |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030307 |
positive regulation of cell growth |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-9029434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-NUL-3876071 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Li, P et al. (2012) P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation. Mol. Biol. Cell 23 1582-92 PubMed GONUTS page
- ↑ Oh, YT et al. (2012) Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J. Biol. Chem. 287 257-67 PubMed GONUTS page
- ↑ 3.0 3.1 Shimamura, A et al. (2000) Rsk1 mediates a MEK-MAP kinase cell survival signal. Curr. Biol. 10 127-35 PubMed GONUTS page
- ↑ 4.0 4.1 Chen, J et al. (2008) Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp. Neurol. 211 529-38 PubMed GONUTS page
- ↑ Buck, M et al. (2001) C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol. Cell 8 807-16 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
- ↑ 8.0 8.1 Moller, DE et al. (1994) Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266 C351-9 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 Anjum, R & Blenis, J (2008) The RSK family of kinases: emerging roles in cellular signalling. Nat. Rev. Mol. Cell Biol. 9 747-58 PubMed GONUTS page
c
n
o
p
- GO:0016310 ! phosphorylation
- GO:0030307 ! positive regulation of cell growth
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045597 ! positive regulation of cell differentiation
- GO:2000491 ! positive regulation of hepatic stellate cell activation
- Primates
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
- GO:0004712 ! protein serine/threonine/tyrosine kinase activity
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