HUMAN:KPCZ

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKCZ (synonyms: PKC2)
Protein Name(s)	Protein kinase C zeta type nPKC-zeta
External Links
UniProt	Q05513
EMBL	L14283 BT007082 AK290995 AK294649 AK294782 AL162271 AL391845 AL590822 AL645703 AL645703 AL391845 AL590822 BC008058 BC014270 Z15108
CCDS	CCDS37.1 CCDS41229.1 CCDS55563.1
PIR	JN0877
RefSeq	NP_001028753.1 NP_001028754.1 NP_001229803.1 NP_002735.3
UniGene	Hs.496255
ProteinModelPortal	Q05513
SMR	Q05513
BioGrid	111576
IntAct	Q05513
MINT	MINT-5004464
STRING	9606.ENSP00000367830
BindingDB	Q05513
ChEMBL	CHEMBL3438
DrugBank	DB00675
GuidetoPHARMACOLOGY	1491
PhosphoSite	Q05513
BioMuta	PRKCZ
DMDM	68067736
MaxQB	Q05513
PaxDb	Q05513
PRIDE	Q05513
DNASU	5590
Ensembl	ENST00000378567 ENST00000400920 ENST00000400921 ENST00000461106
GeneID	5590
KEGG	hsa:5590
UCSC	uc001aiq.3 uc001ait.3
CTD	5590
GeneCards	GC01P001982
H-InvDB	HIX0000049 HIX0029201
HGNC	HGNC:9412
HPA	CAB004533 HPA021851
MIM	176982
neXtProt	NX_Q05513
PharmGKB	PA33775
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	Q05513
KO	K18952
OMA	RCHVLVP
OrthoDB	EOG7HF1J3
PhylomeDB	Q05513
TreeFam	TF102004
BRENDA	2.7.11.13
Reactome	REACT_120726 REACT_1695 REACT_264273
SignaLink	Q05513
ChiTaRS	PRKCZ
GeneWiki	Protein_kinase_M_zeta/Protein_kinase_C_zeta
GenomeRNAi	5590
NextBio	21684
PMAP-CutDB	Q05513
PRO	PR:Q05513
Proteomes	UP000005640
Bgee	Q05513
CleanEx	HS_PRKCZ
ExpressionAtlas	Q05513
Genevisible	Q05513
GO	GO:0045179 GO:0016324 GO:0043203 GO:0005923 GO:0030054 GO:0031252 GO:0005911 GO:0005737 GO:0005829 GO:0005768 GO:0070062 GO:0031941 GO:0016020 GO:0045121 GO:0005815 GO:0035748 GO:0005635 GO:0016363 GO:0048471 GO:0005886 GO:0005524 GO:0043560 GO:0046872 GO:0015459 GO:0004672 GO:0004697 GO:0004674 GO:0031532 GO:0031584 GO:0032148 GO:0007596 GO:0016477 GO:0030010 GO:0006954 GO:0008286 GO:0007616 GO:0060291 GO:0060081 GO:0000226 GO:0043066 GO:0051346 GO:0046627 GO:0050732 GO:0031333 GO:1990138 GO:0018105 GO:0030168 GO:0008284 GO:0001954 GO:0070374 GO:2000463 GO:0046326 GO:0046628 GO:2001181 GO:2000667 GO:0032753 GO:2000664 GO:0051092 GO:2000553 GO:0045630 GO:0051291 GO:0070528 GO:0072659 GO:0006468 GO:0007165 GO:0007179 GO:0048010 GO:0047496
InterPro	IPR000961 IPR020454 IPR011009 IPR000270 IPR002219 IPR012233 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24357:SF60
Pfam	PF00130 PF00564 PF00069 PF00433
PIRSF	PIRSF000554
PRINTS	PR00008
SMART	SM00109 SM00666 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS51745 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005624	membrane fraction		ECO:0000304			C		Source: ProtInc	Missing: reference
	GO:0005886	plasma membrane		ECO:0000304			C		Source: ProtInc	Missing: reference
	GO:0004700	atypical protein kinase C activity		ECO:0000304			F		Source: ProtInc	Missing: reference
	GO:0006916	anti-apoptosis		ECO:0000304			P		Source: ProtInc	Missing: reference
	GO:0006468	protein amino acid phosphorylation		ECO:0000304			P		Source: ProtInc	Missing: reference
part_of	GO:0031982	vesicle	PMID:17313651^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:17313651^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	PMID:15069075^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:15069075^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:15069075^[3]	ECO:0000305	curator inference used in manual assertion	GO:0018105	F		Seeded From UniProt	complete
involved_in	GO:0031333	negative regulation of protein complex assembly	PMID:15069075^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:15069075^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15069075^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2001181	positive regulation of interleukin-10 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02956	P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02956	P		Seeded From UniProt	complete
involved_in	GO:2000664	positive regulation of interleukin-5 secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02956	P		Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02956	P		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09217	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:11035106^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09217	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09217	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09217	P		Seeded From UniProt	complete
involved_in	GO:0045630	positive regulation of T-helper 2 cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02956	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q02956	P		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09217	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10770950^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:20332120^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10770950^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:12391145^[8]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000463	positive regulation of excitatory postsynaptic potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
involved_in	GO:0098696	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	F		Seeded From UniProt	complete
involved_in	GO:0070528	protein kinase C signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0060081	membrane hyperpolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0051346	negative regulation of hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0051222	positive regulation of protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0050806	positive regulation of synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
involved_in	GO:0047496	vesicle transport along microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0031584	activation of phospholipase D activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
involved_in	GO:0030010	establishment of cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
enables	GO:0015459	potassium channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	F		Seeded From UniProt	complete
involved_in	GO:0001954	positive regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	P		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09217 ensembl:ENSRNOP00000021285	C		Seeded From UniProt	complete
involved_in	GO:2001181	positive regulation of interleukin-10 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
involved_in	GO:2000667	positive regulation of interleukin-13 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
involved_in	GO:2000664	positive regulation of interleukin-5 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
involved_in	GO:2000553	positive regulation of T-helper 2 cell cytokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
involved_in	GO:1990138	neuron projection extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
involved_in	GO:0045630	positive regulation of T-helper 2 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
part_of	GO:0045179	apical cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0043203	axon hillock	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0035748	myelin sheath abaxonal region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	F		Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02956 ensembl:ENSMUSP00000030922	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR034662	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR012233 InterPro:IPR017892	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR012233 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10770953^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7925449^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8224878^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:7925449^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7925449^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	Reactome:R-NUL-2161165 Reactome:R-NUL-2161160 Reactome:R-NUL-2161147 Reactome:R-HSA-2160935 Reactome:R-HSA-2160932 Reactome:R-HSA-2160931	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	Reactome:R-HSA-2173791	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9626817 Reactome:R-HSA-5218823 Reactome:R-HSA-5218821 Reactome:R-HSA-5218813 Reactome:R-HSA-5218805	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Fritzius, T et al. (2007) WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. FEBS J. 274 1552-66 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Moeschel, K et al. (2004) Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J. Biol. Chem. 279 25157-63 PubMed GONUTS page
↑ Monick, MM et al. (2000) Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. J. Immunol. 165 4632-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Frasch, SC et al. (2000) Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J. Biol. Chem. 275 23065-73 PubMed GONUTS page
↑ Lampugnani, MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J. Cell. Sci. 123 1073-80 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shu, X et al. (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22 7758-68 PubMed GONUTS page
↑ Rust, C et al. (2000) The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 275 20210-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Tippmer, S et al. (1994) Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta. Eur. J. Biochem. 225 297-304 PubMed GONUTS page
↑ Barbee, JL et al. (1993) The cDNA sequence encoding human protein kinase C-zeta. Gene 132 305-6 PubMed GONUTS page

[PMID:17313651-1] 1.0 ^1.1 Fritzius, T et al. (2007) WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. FEBS J. 274 1552-66 PubMed GONUTS page

[PMID:19056867-2] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:15069075-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Moeschel, K et al. (2004) Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1. J. Biol. Chem. 279 25157-63 PubMed GONUTS page

[PMID:11035106-4] Monick, MM et al. (2000) Protein kinase C zeta plays a central role in activation of the p42/44 mitogen-activated protein kinase by endotoxin in alveolar macrophages. J. Immunol. 165 4632-9 PubMed GONUTS page

[PMID:10770950-5] 5.0 ^5.1 Frasch, SC et al. (2000) Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J. Biol. Chem. 275 23065-73 PubMed GONUTS page

[PMID:20332120-6] Lampugnani, MG et al. (2010) CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J. Cell. Sci. 123 1073-80 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12391145-8] Shu, X et al. (2002) Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22 7758-68 PubMed GONUTS page

[PMID:10770953-9] Rust, C et al. (2000) The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 275 20210-6 PubMed GONUTS page

[PMID:7925449-10] 10.0 ^10.1 ^10.2 Tippmer, S et al. (1994) Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta. Eur. J. Biochem. 225 297-304 PubMed GONUTS page

[PMID:8224878-11] Barbee, JL et al. (1993) The cDNA sequence encoding human protein kinase C-zeta. Gene 132 305-6 PubMed GONUTS page

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