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HUMAN:KLK1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KLK1 | |
| Protein Name(s) | Kallikrein-1
Kidney/pancreas/salivary gland kallikrein Tissue kallikrein | |
| External Links | ||
| UniProt | P06870 | |
| EMBL | M25629 M33109 M33105 M33106 M33107 M33108 X13561 AF277050 AF243527 AY703451 BT007253 AY094609 AC010325 BC005313 M12706 | |
| CCDS | CCDS12804.1 | |
| PIR | A24696 B24696 | |
| RefSeq | NP_002248.1 | |
| UniGene | Hs.123107 | |
| PDB | 1SPJ | |
| PDBsum | 1SPJ | |
| ProteinModelPortal | P06870 | |
| SMR | P06870 | |
| BioGrid | 110016 | |
| STRING | 9606.ENSP00000301420 | |
| BindingDB | P06870 | |
| ChEMBL | CHEMBL2319 | |
| DrugBank | DB06692 | |
| UniCarbKB | P06870 | |
| DMDM | 269849612 | |
| PaxDb | P06870 | |
| PRIDE | P06870 | |
| DNASU | 3816 | |
| Ensembl | ENST00000301420 | |
| GeneID | 3816 | |
| KEGG | hsa:3816 | |
| UCSC | uc002ptk.1 | |
| CTD | 3816 | |
| GeneCards | GC19M051322 | |
| HGNC | HGNC:6357 | |
| MIM | 147910 | |
| neXtProt | NX_P06870 | |
| PharmGKB | PA224 | |
| eggNOG | COG5640 | |
| GeneTree | ENSGT00760000118862 | |
| HOVERGEN | HBG013304 | |
| InParanoid | P06870 | |
| KO | K01325 | |
| OMA | HTQKVTE | |
| PhylomeDB | P06870 | |
| TreeFam | TF331065 | |
| BRENDA | 3.4.21.35 | |
| Reactome | REACT_15428 | |
| ChiTaRS | KLK1 | |
| EvolutionaryTrace | P06870 | |
| GeneWiki | KLK1 | |
| GenomeRNAi | 3816 | |
| NextBio | 15001 | |
| PRO | PR:P06870 | |
| Proteomes | UP000005640 | |
| Bgee | P06870 | |
| CleanEx | HS_KLK1 | |
| ExpressionAtlas | P06870 | |
| Genevestigator | P06870 | |
| GO | GO:0070062 GO:0005634 GO:0004252 | |
| InterPro | IPR001254 IPR018114 IPR001314 IPR009003 | |
| Pfam | PF00089 | |
| PRINTS | PR00722 | |
| SMART | SM00020 | |
| SUPFAM | SSF50494 | |
| PROSITE | PS50240 PS00134 PS00135 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008233 |
peptidase activity |
ECO:0000314 |
F |
Figure 5 shows the preteolytic activity in Escherichia Coli after being introduced to the mutated plasmid DNA. |
complete | |||||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031638 |
zymogen activation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:891981 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:3615275 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003073 |
regulation of systemic arterial blood pressure |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:892019 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Fukushima, D et al. (1985) Nucleotide sequence of cloned cDNA for human pancreatic kallikrein. Biochemistry 24 8037-43 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Son, do N et al. (2009) Abundant expression of Kallikrein 1 gene in human keratinocytes was mediated by GATA3. Gene 436 121-7 PubMed GONUTS page
- ↑ Chen, LM et al. (1994) Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues. Braz. J. Med. Biol. Res. 27 1829-38 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Angermann, A et al. (1989) Cloning and expression of human salivary-gland kallikrein in Escherichia coli. Biochem. J. 262 787-93 PubMed GONUTS page
