HUMAN:KLF5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KLF5 (synonyms: BTEB2, CKLF, IKLF)
Protein Name(s)	Krueppel-like factor 5 Basic transcription element-binding protein 2 BTE-binding protein 2 Colon krueppel-like factor GC-box-binding protein 2 Intestinal-enriched krueppel-like factor Transcription factor BTEB2
External Links
UniProt	Q13887
EMBL	AF132818 HF546203 HF546204 AB030824 AF287272 BC007695 BC042131 D14520
CCDS	CCDS9448.1
PIR	S35643
RefSeq	NP_001273747.1 NP_001721.2
UniGene	Hs.508234
PDB	2EBT
PDBsum	2EBT
ProteinModelPortal	Q13887
SMR	Q13887
BioGrid	107153
IntAct	Q13887
MINT	MINT-3028757
STRING	9606.ENSP00000366915
BindingDB	Q13887
PhosphoSite	Q13887
DMDM	12644412
MaxQB	Q13887
PaxDb	Q13887
PRIDE	Q13887
DNASU	688
Ensembl	ENST00000377687
GeneID	688
KEGG	hsa:688
UCSC	uc001vjd.3
CTD	688
GeneCards	GC13P073629
HGNC	HGNC:6349
HPA	HPA040398 HPA044231
MIM	602903
neXtProt	NX_Q13887
PharmGKB	PA30139
eggNOG	COG5048
HOGENOM	HOG000261607
HOVERGEN	HBG003474
InParanoid	Q13887
KO	K09206
OMA	MPNQFLQ
OrthoDB	EOG747PJ4
PhylomeDB	Q13887
TreeFam	TF350556
Reactome	REACT_27161
SignaLink	Q13887
ChiTaRS	KLF5
EvolutionaryTrace	Q13887
GeneWiki	KLF5
GenomeRNAi	688
NextBio	2832
PRO	PR:Q13887
Proteomes	UP000005640
Bgee	Q13887
CleanEx	HS_CKLF HS_KLF5
ExpressionAtlas	Q13887
Genevestigator	Q13887
GO	GO:0005737 GO:0005794 GO:0043231 GO:0005634 GO:0005886 GO:0046872 GO:0000978 GO:0001077 GO:0001525 GO:0071407 GO:1901653 GO:0060576 GO:0030033 GO:0000122 GO:0008284 GO:0045944 GO:0032534 GO:0035914 GO:0006366
Gene3D	3.30.160.60
InterPro	IPR030401 IPR007087 IPR015880 IPR013087
PANTHER	PTHR23223:SF144
SMART	SM00355
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	PMID:21487105^[1]	ECO:0000314			P		Figure 3 details a number of experiments involving the expression and activity of FOXO1. Figure 3A shows that the presence of the KLF5 gene product, provided on a plasmid vector, is required for any expression of FOXO1 above baseline as measured by RNA pol II production of luciferase expressed in tandem with the FOXO1 gene in human cell culture.	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:28408180^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000283904) occurs_in:(CL:0002539)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q9JHX2	F		Seeded From UniProt	complete
involved_in	GO:0099156	cell-cell signaling via exosome	PMID:28408180^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16595680^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:332)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:16595680^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16595680^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1354948 MGI:MGI:2153049 MGI:MGI:2153568 MGI:MGI:2181068 MGI:MGI:98968 PANTHER:PTN001145452 RGD:3738 UniProtKB:A0A1D8PNL1 UniProtKB:Q02446 UniProtKB:Q7RTV3 ZFIN:ZDB-GENE-021115-9	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0043364 FB:FBgn0261434 FB:FBgn0263239 MGI:MGI:1101353 MGI:MGI:1277166 MGI:MGI:1333856 MGI:MGI:1338056 MGI:MGI:1342287 MGI:MGI:1342772 MGI:MGI:1346318 MGI:MGI:1929988 MGI:MGI:1932575 MGI:MGI:2153568 MGI:MGI:95295 MGI:MGI:95296 MGI:MGI:98372 MGI:MGI:98968 PANTHER:PTN001145452 RGD:1306768 RGD:2544 RGD:3738 RGD:3741 RGD:3974 RGD:621445 RGD:621652 RGD:62389 UniProtKB:A0A0B4KHC8 UniProtKB:A0A0G2K5M1 UniProtKB:P18146 UniProtKB:P19544 UniProtKB:Q02086 UniProtKB:Q13351 UniProtKB:Q13886 UniProtKB:Q7RTV3 UniProtKB:Q8TDD2 UniProtKB:Q99612 UniProtKB:Q9UIH9 WB:WBGene00007772 WB:WBGene00012735	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001145452 UniProtKB:O14901 UniProtKB:Q9Y5W3 WB:WBGene00012735 ZFIN:ZDB-GENE-021115-9	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1901653	cellular response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSL7 ensembl:ENSRNOP00000054653	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSL7 ensembl:ENSRNOP00000054653	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSL7 ensembl:ENSRNOP00000054653	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSL7 ensembl:ENSRNOP00000054653	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSL7 ensembl:ENSRNOP00000054653	F		Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0061586	positive regulation of transcription by transcription factor localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0060576	intestinal epithelial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
enables	GO:0043426	MRF binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	F		Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0035914	skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0032534	regulation of microvillus assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0030033	microvillus assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0014908	myotube differentiation involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0014901	satellite cell activation involved in skeletal muscle regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0014816	skeletal muscle satellite cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z0Z7 ensembl:ENSMUSP00000005279	P		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030401	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030401	P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:8479902^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Zheng, B et al. (2017) Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis. Mol. Ther. 25 1279-1294 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhu, N et al. (2006) KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia. J. Biol. Chem. 281 14711-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sogawa, K et al. (1993) cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res. 21 1527-32 PubMed GONUTS page

[PMID:21487105-1] Nakajima, Y et al. (2011) Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5. Sci Signal 4 ra22 PubMed GONUTS page

[PMID:19274049-2] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:28408180-3] 3.0 ^3.1 Zheng, B et al. (2017) Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis. Mol. Ther. 25 1279-1294 PubMed GONUTS page

[PMID:16595680-4] 4.0 ^4.1 ^4.2 Zhu, N et al. (2006) KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia. J. Biol. Chem. 281 14711-8 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8479902-6] Sogawa, K et al. (1993) cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2. Nucleic Acids Res. 21 1527-32 PubMed GONUTS page

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HUMAN:KLF5

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