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HUMAN:KEAP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KEAP1 (synonyms: INRF2, KIAA0132, KLHL19) | |
| Protein Name(s) | Kelch-like ECH-associated protein 1
Cytosolic inhibitor of Nrf2 INrf2 Kelch-like protein 19 | |
| External Links | ||
| UniProt | Q14145 | |
| EMBL | AF361892 AF361888 AF361889 AF361890 AF361891 AF361886 D50922 AK056204 AC011461 BC002417 BC002930 BC015945 BC021957 | |
| CCDS | CCDS12239.1 | |
| RefSeq | NP_036421.2 NP_987096.1 XP_005260230.1 XP_005260231.1 | |
| UniGene | Hs.465870 | |
| PDB | 1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B | |
| PDBsum | 1U6D 1ZGK 2FLU 3VNG 3VNH 3ZGC 3ZGD 4CXI 4CXJ 4CXT 4IFJ 4IFL 4IFN 4IN4 4IQK 4L7B 4L7C 4L7D 4N1B | |
| ProteinModelPortal | Q14145 | |
| SMR | Q14145 | |
| BioGrid | 115156 | |
| DIP | DIP-42134N | |
| IntAct | Q14145 | |
| MINT | MINT-1197065 | |
| STRING | 9606.ENSP00000171111 | |
| ChEMBL | CHEMBL3038498 | |
| DrugBank | DB08908 | |
| PhosphoSite | Q14145 | |
| DMDM | 146345444 | |
| MaxQB | Q14145 | |
| PaxDb | Q14145 | |
| PRIDE | Q14145 | |
| DNASU | 9817 | |
| Ensembl | ENST00000171111 ENST00000393623 | |
| GeneID | 9817 | |
| KEGG | hsa:9817 | |
| UCSC | uc002moq.1 | |
| CTD | 9817 | |
| GeneCards | GC19M010596 | |
| HGNC | HGNC:23177 | |
| HPA | CAB025337 HPA005558 | |
| MIM | 606016 | |
| neXtProt | NX_Q14145 | |
| PharmGKB | PA134887774 | |
| eggNOG | NOG255039 | |
| GeneTree | ENSGT00760000118931 | |
| HOGENOM | HOG000230814 | |
| HOVERGEN | HBG014286 | |
| InParanoid | Q14145 | |
| KO | K10456 | |
| OMA | ERYEPEG | |
| OrthoDB | EOG76739M | |
| PhylomeDB | Q14145 | |
| TreeFam | TF329218 | |
| Reactome | REACT_75842 | |
| UniPathway | UPA00143 | |
| EvolutionaryTrace | Q14145 | |
| GeneWiki | KEAP1 | |
| GenomeRNAi | 9817 | |
| NextBio | 36968 | |
| PRO | PR:Q14145 | |
| Proteomes | UP000005640 | |
| Bgee | Q14145 | |
| CleanEx | HS_KEAP1 | |
| ExpressionAtlas | Q14145 | |
| Genevestigator | Q14145 | |
| GO | GO:0031463 GO:0005737 GO:0005829 GO:0005783 GO:0005815 GO:0030496 GO:0005634 GO:0008134 GO:0071353 GO:0001701 GO:0043433 GO:0032436 GO:0010499 GO:0016567 GO:0045604 GO:0006351 | |
| Gene3D | 2.130.10.80 | |
| InterPro | IPR011705 IPR000210 IPR011333 IPR013069 IPR015916 IPR017096 IPR006652 | |
| Pfam | PF07707 PF00651 PF01344 | |
| PIRSF | PIRSF037037 | |
| SMART | SM00875 SM00225 SM00612 | |
| SUPFAM | SSF54695 | |
| PROSITE | PS50097 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030496 |
midbody |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010499 |
proteasomal ubiquitin-independent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042994 |
cytoplasmic sequestering of transcription factor |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000697162 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000697162 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0030972 |
cleavage of cytosolic proteins involved in apoptosis |
ECO:0000315 |
P |
Fig. 8D |
complete | |||||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0097718 |
disordered domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
F |
Seeded From UniProt |
complete | ||
| GO:0032270 |
positive regulation of cellular protein metabolic process |
ECO:0000315 |
P |
Fig. 8A |
complete | |||||
|
involved_in |
GO:0071353 |
cellular response to interleukin-4 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
P |
Seeded From UniProt |
complete | ||
| GO:0016567 |
protein ubiquitination |
ECO:0000315 |
P |
Fig. 3A |
complete | |||||
|
involved_in |
GO:0045604 |
regulation of epidermal cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
P |
Seeded From UniProt |
complete | ||
| GO:0045732 |
positive regulation of protein catabolic process |
ECO:0000315 |
P |
Fig. 1 and Fig. 8A |
complete | |||||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005884 |
actin filament |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001701 |
in utero embryonic development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9Z2X8 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008134 |
transcription factor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031463 |
Cul3-RING ubiquitin ligase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032436 |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q16236) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043433 |
negative regulation of DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
PMID:17015834[1] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0043687 |
post-translational protein modification |
Reactome:R-HSA-597592 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016579 |
protein deubiquitination |
Reactome:R-HSA-5688426 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016567 |
protein ubiquitination |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00143 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Zhang, DD et al. (2005) Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J. Biol. Chem. 280 30091-9 PubMed GONUTS page
- ↑ Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page
- ↑ Wang, XJ & Zhang, DD (2009) Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS ONE 4 e5492 PubMed GONUTS page
- ↑ 5.0 5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page
c
n
o
p
- GO:0032270 ! positive regulation of cellular protein metabolic process
- GO:0045732 ! positive regulation of protein catabolic process
- GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- GO:0043687 ! post-translational protein modification
- Primates
- GO:0010499 ! proteasomal ubiquitin-independent protein catabolic process
- GO:0032991 ! protein-containing complex
- GO:0016579 ! protein deubiquitination
- GO:0042803 ! protein homodimerization activity
- GO:0016567 ! protein ubiquitination
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