HUMAN:JIP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAPK8IP1 (synonyms: IB1, JIP1, PRKM8IP)
Protein Name(s)	C-Jun-amino-terminal kinase-interacting protein 1 JIP-1 JNK-interacting protein 1 Islet-brain 1 IB-1 JNK MAP kinase scaffold protein 1 Mitogen-activated protein kinase 8-interacting protein 1
External Links
UniProt	Q9UQF2
EMBL	AF074091 CH471064 CH471064 AF007134
CCDS	CCDS7916.1
RefSeq	NP_005447.1
UniGene	Hs.234249
PDB	2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY
PDBsum	2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY
ProteinModelPortal	Q9UQF2
SMR	Q9UQF2
BioGrid	114864
IntAct	Q9UQF2
MINT	MINT-111691
STRING	9606.ENSP00000241014
PhosphoSite	Q9UQF2
DMDM	17433093
PaxDb	Q9UQF2
PRIDE	Q9UQF2
Ensembl	ENST00000241014
GeneID	9479
KEGG	hsa:9479
UCSC	uc001nbr.3
CTD	9479
GeneCards	GC11P045908
HGNC	HGNC:6882
HPA	CAB013289
MIM	125853 604641
neXtProt	NX_Q9UQF2
PharmGKB	PA30626
eggNOG	NOG266073
GeneTree	ENSGT00390000003908
HOGENOM	HOG000231470
HOVERGEN	HBG018568
InParanoid	Q9UQF2
KO	K04434
OMA	SPCRRSA
OrthoDB	EOG74J97M
PhylomeDB	Q9UQF2
TreeFam	TF325073
SignaLink	Q9UQF2
ChiTaRS	MAPK8IP1
EvolutionaryTrace	Q9UQF2
GeneWiki	MAPK8IP1
GenomeRNAi	9479
NextBio	35528
PRO	PR:Q9UQF2
Proteomes	UP000005640
Bgee	Q9UQF2
CleanEx	HS_MAPK8IP1
ExpressionAtlas	Q9UQF2
Genevestigator	Q9UQF2
GO	GO:0044295 GO:0044297 GO:0005737 GO:0005829 GO:0044294 GO:0044302 GO:0005789 GO:0031966 GO:0005634 GO:0048471 GO:0045202 GO:0019894 GO:0005078 GO:0004860 GO:0007258 GO:2001243 GO:0043508 GO:0046328 GO:0006355 GO:0016192
Gene3D	2.30.29.30
InterPro	IPR011993 IPR006020 IPR001452
Pfam	PF00640 PF14604
SMART	SM00462 SM00326
SUPFAM	SSF50044
PROSITE	PS01179 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005078	MAP-kinase scaffold activity	PMID:11238452^[1]	ECO:0000021		UniProtKB:P45983	F		complete
involved_in	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVI9	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVI9	P	Seeded From UniProt	complete
involved_in	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R237	P	Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVI9	P	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	PMID:11238452^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07866	F	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P34609	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10574993^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005078	MAP-kinase scaffold activity	PMID:11238452^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P45983	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	C	Seeded From UniProt	complete
involved_in	GO:0046329	negative regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	P	Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	C	Seeded From UniProt	complete
part_of	GO:0044294	dendritic growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	C	Seeded From UniProt	complete
involved_in	GO:0043508	negative regulation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	P	Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	F	Seeded From UniProt	complete
enables	GO:0031434	mitogen-activated protein kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	F	Seeded From UniProt	complete
enables	GO:0008432	JUN kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	C	Seeded From UniProt	complete
enables	GO:0005078	MAP-kinase scaffold activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9R237 ensembl:ENSRNOP00000074684	F	Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
involved_in	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
part_of	GO:0044302	dentate gyrus mossy fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	F	Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	F	Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
involved_in	GO:0007258	JUN phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9WVI9 ensembl:ENSMUSP00000050773	C	Seeded From UniProt	complete
enables	GO:0004860	protein kinase inhibitor activity	PMID:9933567^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C	Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Verhey, KJ et al. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152 959-70 PubMed GONUTS page
↑ Meyer, D et al. (1999) Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J. Biol. Chem. 274 35113-8 PubMed GONUTS page
↑ Mooser, V et al. (1999) Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. Genomics 55 202-8 PubMed GONUTS page

[PMID:11238452-1] 1.0 ^1.1 ^1.2 Verhey, KJ et al. (2001) Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152 959-70 PubMed GONUTS page

[PMID:10574993-2] Meyer, D et al. (1999) Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. J. Biol. Chem. 274 35113-8 PubMed GONUTS page

[PMID:9933567-3] Mooser, V et al. (1999) Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. Genomics 55 202-8 PubMed GONUTS page

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HUMAN:JIP1

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