HUMAN:INO80

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	INO80 (synonyms: INO80A, INOC1, KIAA1259)
Protein Name(s)	DNA helicase INO80 hINO80 INO80 complex subunit A Putative DNA helicase INO80 complex homolog 1
External Links
UniProt	Q9ULG1
EMBL	AB033085 CH471125 BC146785 AL137280
CCDS	CCDS10071.1
PIR	T46350
RefSeq	NP_060023.1
UniGene	Hs.292949
ProteinModelPortal	Q9ULG1
SMR	Q9ULG1
BioGrid	120076
DIP	DIP-34296N
IntAct	Q9ULG1
STRING	9606.ENSP00000355205
PhosphoSite	Q9ULG1
DMDM	114149322
MaxQB	Q9ULG1
PaxDb	Q9ULG1
PRIDE	Q9ULG1
Ensembl	ENST00000361937 ENST00000401393
GeneID	54617
KEGG	hsa:54617
UCSC	uc001zni.3
CTD	54617
GeneCards	GC15M041271
HGNC	HGNC:26956
HPA	HPA055495
MIM	610169
neXtProt	NX_Q9ULG1
PharmGKB	PA162392040
eggNOG	COG0553
GeneTree	ENSGT00740000115601
HOGENOM	HOG000231795
HOVERGEN	HBG057875
InParanoid	Q9ULG1
KO	K11665
OMA	RRKEGMN
OrthoDB	EOG7B05C6
PhylomeDB	Q9ULG1
TreeFam	TF324408
ChiTaRS	INO80
GenomeRNAi	54617
NextBio	57137
PRO	PR:Q9ULG1
Proteomes	UP000005640
Bgee	Q9ULG1
CleanEx	HS_INO80
ExpressionAtlas	Q9ULG1
Genevestigator	Q9ULG1
GO	GO:0031011 GO:0005874 GO:0005634 GO:0043014 GO:0005524 GO:0016887 GO:0003677 GO:0003678 GO:0006200 GO:0071479 GO:0034644 GO:0006338 GO:0032508 GO:0006302 GO:0000724 GO:0000070 GO:0030307 GO:0010571 GO:0045944 GO:2000045 GO:0051225 GO:0070914
Gene3D	3.40.50.300
InterPro	IPR020838 IPR014001 IPR001650 IPR027417 IPR000330
Pfam	PF13892 PF00271 PF00176
SMART	SM00487 SM00490
SUPFAM	SSF52540
PROSITE	PS51413 PS51192 PS51194

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0006302	double-strand break repair	PMID:20687897^[1]	ECO:0000316		UniProtKB:Q9ULG1	P	Figure 1 hINO80 knockdown confers DNA-damage sensitivity and inefficient DSB repair Figure 4 hINO80 binds to the promoters of the Rad54B and XRCC3 genes Figure 5 Re-expression of Rad54B and XRCC3 rescues the DSB repair defect in hINO80-deficient cells	complete CACAO 10387
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P53115	P	Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	PMID:20237820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:20687897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070914	UV-damage excision repair	PMID:20855601^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051225	spindle assembly	PMID:20237820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20687897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	PMID:20237820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:18026119^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031011	Ino80 complex	PMID:21303910^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0031011	Ino80 complex	PMID:18026119^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:20237820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008094	DNA-dependent ATPase activity	PMID:16298340^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0010571	positive regulation of nuclear cell cycle DNA replication	PMID:20237820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	PMID:20687897^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18026119^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16298340^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16298340^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:18026119^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:20237820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001521025 SGD:S000003118	P	Seeded From UniProt	complete
contributes_to	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001521025 SGD:S000003118	F	Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002904112 PomBase:SPAC29B12.01	P	Seeded From UniProt	complete
involved_in	GO:0042766	nucleosome mobilization	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001521025 SGD:S000003118	P	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002904112 UniProtKB:Q8RXS6	F	Seeded From UniProt	complete
part_of	GO:0031011	Ino80 complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0086613 PANTHER:PTN001521025 PomBase:SPAC29B12.01 SGD:S000003118 UniProtKB:Q9ULG1	C	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002904112 SGD:S000003118	F	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002904112 PomBase:SPAC11E3.01c PomBase:SPAC29B12.01 SGD:S000002742 SGD:S000003118	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001521025 SGD:S000003118	P	Seeded From UniProt	complete
part_of	GO:0045111	intermediate filament cytoskeleton	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043140	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020838	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000330	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031047	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031047	P	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031047	P	Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031047	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031047	F	Seeded From UniProt	complete
part_of	GO:0031011	Ino80 complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031047	C	Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5689544	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0233	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Park, EJ et al. (2010) Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes. Biochem. J. 431 179-87 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Hur, SK et al. (2010) Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. Cell. Mol. Life Sci. 67 2283-96 PubMed GONUTS page
↑ Jiang, Y et al. (2010) INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Proc. Natl. Acad. Sci. U.S.A. 107 17274-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Wu, S et al. (2007) A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat. Struct. Mol. Biol. 14 1165-72 PubMed GONUTS page
↑ Chen, L et al. (2011) Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J. Biol. Chem. 286 11283-9 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Bakshi, R et al. (2006) Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. Biochem. Biophys. Res. Commun. 339 313-20 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20687897-1] 1.0 ^1.1 ^1.2 ^1.3 Park, EJ et al. (2010) Human INO80 chromatin-remodelling complex contributes to DNA double-strand break repair via the expression of Rad54B and XRCC3 genes. Biochem. J. 431 179-87 PubMed GONUTS page

[PMID:20237820-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Hur, SK et al. (2010) Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability. Cell. Mol. Life Sci. 67 2283-96 PubMed GONUTS page

[PMID:20855601-3] Jiang, Y et al. (2010) INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Proc. Natl. Acad. Sci. U.S.A. 107 17274-9 PubMed GONUTS page

[PMID:18026119-4] 4.0 ^4.1 ^4.2 ^4.3 Wu, S et al. (2007) A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat. Struct. Mol. Biol. 14 1165-72 PubMed GONUTS page

[PMID:21303910-5] Chen, L et al. (2011) Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J. Biol. Chem. 286 11283-9 PubMed GONUTS page

[PMID:16298340-6] 6.0 ^6.1 ^6.2 Bakshi, R et al. (2006) Characterization of a human SWI2/SNF2 like protein hINO80: demonstration of catalytic and DNA binding activity. Biochem. Biophys. Res. Commun. 339 313-20 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:INO80

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