HUMAN:IMDH1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IMPDH1 (ECO:0000255 with HAMAP-Rule:MF_03156) (synonyms: IMPD1)
Protein Name(s)	Inosine-5'-monophosphate dehydrogenase 1 (ECO:0000255 with HAMAP-Rule:MF_03156) IMP dehydrogenase 1 (ECO:0000255 with HAMAP-Rule:MF_03156) IMPD 1 (ECO:0000255 with HAMAP-Rule:MF_03156) IMPDH 1 (ECO:0000255 with HAMAP-Rule:MF_03156) IMPDH-I
External Links
UniProt	P20839
EMBL	J05272 AK054640 AK054667 AK122994 AK293413 AC010655 CH236947 CH236947 CH471070 BC033622 CD014008
CCDS	CCDS34748.1 CCDS34749.1 CCDS43643.1 CCDS47699.1 CCDS47700.1 CCDS55161.1
PIR	A35566
RefSeq	NP_000874.2 NP_001096075.1 NP_001136045.1 NP_001136046.1 NP_001136047.1 NP_001136048.1 NP_001291450.1 NP_899066.1 XP_016867661.1
PDB	1JCN
PDBsum	1JCN
SMR	P20839
BioGrid	109827
DIP	DIP-60163N
IntAct	P20839
STRING	9606.ENSP00000345096
BindingDB	P20839
ChEMBL	CHEMBL1822
DrugBank	DB03948 DB01033 DB00688 DB01024 DB00157 DB00811 DB06408 DB06103
DrugCentral	P20839
GuidetoPHARMACOLOGY	2624
iPTMnet	P20839
PhosphoSitePlus	P20839
BioMuta	IMPDH1
DMDM	25014074
EPD	P20839
jPOST	P20839
MassIVE	P20839
MaxQB	P20839
PaxDb	P20839
PeptideAtlas	P20839
PRIDE	P20839
ProteomicsDB	11817 53811 53812 53813 53814
Ensembl	ENST00000338791 ENST00000348127 ENST00000354269 ENST00000419067 ENST00000480861 ENST00000496200
GeneID	3614
KEGG	hsa:3614
UCSC	uc003vmt.3
CTD	3614
DisGeNET	3614
GeneCards	IMPDH1
GeneReviews	IMPDH1
HGNC	HGNC:6052
MalaCards	IMPDH1
MIM	146690 180105 613837
neXtProt	NX_P20839
OpenTargets	ENSG00000106348
Orphanet	65 791
PharmGKB	PA29862
eggNOG	ENOG410ISZP COG0517
GeneTree	ENSGT00940000154156
HOGENOM	HOG000165752
KO	K00088
OMA	SSMGYCG
OrthoDB	618077at2759
PhylomeDB	P20839
TreeFam	TF300378
BioCyc	MetaCyc:HS02896-MONOMER
BRENDA	1.1.1.205
Reactome	R-HSA-6798695 R-HSA-73817
SABIO-RK	P20839
UniPathway	UPA00601
ChiTaRS	IMPDH1
EvolutionaryTrace	P20839
GeneWiki	IMPDH1
GenomeRNAi	3614
Pharos	P20839
PRO	PR:P20839
Proteomes	UP000005640
Bgee	ENSG00000106348
ExpressionAtlas	P20839
Genevisible	P20839
GO	GO:0035578 GO:0005737 GO:0005829 GO:0005576 GO:1904813 GO:0005634 GO:0034774 GO:0003677 GO:0003938 GO:0046872 GO:0003676 GO:0000166 GO:0003723 GO:0006177 GO:0006183 GO:0046651 GO:0043312 GO:0009168
CDD	cd00381
Gene3D	3.20.20.70
HAMAP	MF_01964
InterPro	IPR013785 IPR000644 IPR005990 IPR015875 IPR001093
Pfam	PF00571 PF00478
PIRSF	PIRSF000130
SMART	SM00116
TIGRFAMs	TIGR01302
PROSITE	PS51371 PS00487

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.205	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001093 InterPro:IPR005990 InterPro:IPR015875	P	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015875	F	Seeded From UniProt
involved_in	GO:0006164	purine nucleotide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005990	P	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005990	F	Seeded From UniProt
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001093 InterPro:IPR013785	F	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	C	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	F	Seeded From UniProt
enables	GO:0000166	nucleotide binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	F	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	F	Seeded From UniProt
involved_in	GO:0006177	GMP biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	C	Seeded From UniProt
involved_in	GO:0046651	lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50096 ensembl:ENSMUSP00000124931	P	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50096 ensembl:ENSMUSP00000124931	F	Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005634	nucleus	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0003677	DNA binding	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:0003676	nucleic acid binding	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
involved_in	GO:0006183	GTP biosynthetic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000226903 PomBase:SPBC2F12.14c	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000226902 SGD:S000001259 SGD:S000004424 SGD:S000004520 UniProtKB:P12268 UniProtKB:P20839	C	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10421 MGI:MGI:109367 MGI:MGI:96567 PANTHER:PTN000226903 PomBase:SPBC2F12.14c RGD:735092 UniProtKB:P9WKI5 UniProtKB:P9WKI7	F	Seeded From UniProt
involved_in	GO:0006164	purine nucleotide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50096 ensembl:ENSMUSP00000124931	P	Seeded From UniProt
involved_in	GO:0006177	GMP biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0332	P	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt
involved_in	GO:0006164	purine nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0658	P	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000039 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191 UniProtKB-KW:KW-0539	C	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798748 Reactome:R-HSA-6800434 Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	PMID:1969416^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
involved_in	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	Reactome:R-HSA-73817	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt
part_of	GO:0005829	cytosol	Reactome:R-HSA-73794	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
involved_in	GO:0006177	GMP biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0332	P	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.205	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001093 InterPro:IPR005990 InterPro:IPR015875	P	Seeded From UniProt
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015875	F	Seeded From UniProt
involved_in	GO:0006164	purine nucleotide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005990	P	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005990	F	Seeded From UniProt
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001093 InterPro:IPR013785	F	Seeded From UniProt
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt
involved_in	GO:0006164	purine nucleotide biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0658	P	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000039 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191 UniProtKB-KW:KW-0539	C	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0086	C	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	C	Seeded From UniProt
enables	GO:0046872	metal ion binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	F	Seeded From UniProt
enables	GO:0000166	nucleotide binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	F	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	F	Seeded From UniProt
involved_in	GO:0006177	GMP biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000336911	C	Seeded From UniProt
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt
involved_in	GO:0046651	lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50096 ensembl:ENSMUSP00000124931	P	Seeded From UniProt
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798748 Reactome:R-HSA-6800434 Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50096 ensembl:ENSMUSP00000124931	F	Seeded From UniProt
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	PMID:1969416^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
part_of	GO:0005634	nucleus	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt
enables	GO:0003677	DNA binding	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
enables	GO:0003676	nucleic acid binding	PMID:14766016^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt
involved_in	GO:0006183	GTP biosynthetic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000226903 PomBase:SPBC2F12.14c	P	Seeded From UniProt
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000226902 SGD:S000001259 SGD:S000004424 SGD:S000004520 UniProtKB:P12268 UniProtKB:P20839	C	Seeded From UniProt
enables	GO:0003938	IMP dehydrogenase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10421 MGI:MGI:109367 MGI:MGI:96567 PANTHER:PTN000226903 PomBase:SPBC2F12.14c RGD:735092 UniProtKB:P9WKI5 UniProtKB:P9WKI7	F	Seeded From UniProt
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
involved_in	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	Reactome:R-HSA-73817	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt
part_of	GO:0005829	cytosol	Reactome:R-HSA-73794	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt
involved_in	GO:0006164	purine nucleotide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P50096 ensembl:ENSMUSP00000124931	P	Seeded From UniProt
	GO:0003938	IMP dehydrogenase activity	PMID:30451390^[4]	ECO:0000180	clinical study evidence		F	Figure 2: Distribution of IMPDH activity, (a) in the total population (n = 164) and scattergram of the IMPDH activity according to the phenotype of IMPDH, (b) in adults (n = 97), (c) in children (n = 67), (d) in males (n = 75), (e) in women (n = 89), (f) in subjects treated with AZA (n = 124), (g) in subjects not treated with AZA (n = 40).	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 McLean, JE et al. (2004) Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochem. J. 379 243-51 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Natsumeda, Y et al. (1990) Two distinct cDNAs for human IMP dehydrogenase. J. Biol. Chem. 265 5292-5 PubMed GONUTS page
↑ Citterio-Quentin, A et al. (2019) Red Blood cell IMPDH activity in adults and children with or without azathioprine: Relationship between thiopurine metabolites, ITPA and TPMT activities. Basic Clin Pharmacol Toxicol 124 600-606 PubMed GONUTS page

[PMID:14766016-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 McLean, JE et al. (2004) Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo. Biochem. J. 379 243-51 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1969416-3] 3.0 ^3.1 Natsumeda, Y et al. (1990) Two distinct cDNAs for human IMP dehydrogenase. J. Biol. Chem. 265 5292-5 PubMed GONUTS page

[PMID:30451390-4] Citterio-Quentin, A et al. (2019) Red Blood cell IMPDH activity in adults and children with or without azathioprine: Relationship between thiopurine metabolites, ITPA and TPMT activities. Basic Clin Pharmacol Toxicol 124 600-606 PubMed GONUTS page

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HUMAN:IMDH1

Contents

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Notes

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