GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:IF2P

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) EIF5B (synonyms: IF2, KIAA0741)
Protein Name(s) Eukaryotic translation initiation factor 5B

eIF-5B Translation initiation factor IF-2

External Links
UniProt O60841
EMBL AJ006776
AF078035
AC018690
AC079447
AB018284
AL133563
AJ006412
CCDS CCDS42721.1
PIR T43483
RefSeq NP_056988.3
UniGene Hs.158688
ProteinModelPortal O60841
SMR O60841
BioGrid 115024
IntAct O60841
MINT MINT-3000520
STRING 9606.ENSP00000289371
PhosphoSite O60841
MaxQB O60841
PaxDb O60841
PRIDE O60841
Ensembl ENST00000289371
GeneID 9669
KEGG hsa:9669
UCSC uc002tab.3
CTD 9669
GeneCards GC02P099953
H-InvDB HIX0002308
HGNC HGNC:30793
HPA HPA034648
HPA040095
MIM 606086
neXtProt NX_O60841
PharmGKB PA134864457
eggNOG COG0532
GeneTree ENSGT00730000111064
HOGENOM HOG000105770
HOVERGEN HBG019036
InParanoid O60841
KO K03243
OMA GSLRMHT
OrthoDB EOG7034GC
PhylomeDB O60841
TreeFam TF101535
Reactome REACT_2085
ChiTaRS EIF5B
GeneWiki EIF5B
GenomeRNAi 9669
NextBio 36307
PMAP-CutDB O60841
PRO PR:O60841
Proteomes UP000005640
Bgee O60841
CleanEx HS_EIF5B
ExpressionAtlas O60841
Genevestigator O60841
GO GO:0005829
GO:0005525
GO:0003924
GO:0044822
GO:0003743
GO:0044267
GO:0010467
GO:0006446
GO:0006412
GO:0006413
Gene3D 3.40.50.10050
3.40.50.300
InterPro IPR000795
IPR029459
IPR027417
IPR005225
IPR023115
IPR009000
IPR004161
Pfam PF00009
PF03144
PF14578
PF11987
PRINTS PR00315
SUPFAM SSF50447
SSF52156
SSF52540
TIGRFAMs TIGR00231
PROSITE PS51722

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT|part_of

GO:0005634

nucleus

PMID:12426392[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12426392[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006446

regulation of translational initiation

PMID:10432305[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006446

regulation of translational initiation

PMID:10200264[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

PMID:10432305[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

PMID:10200264[5]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000561881
SGD:S000000033
UniProtKB:O60841

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000795

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000795
InterPro:IPR004161
InterPro:IPR005225

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-72672
Reactome:R-HSA-72671

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0396

F

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0396

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bohnsack, MT et al. (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 21 6205-15 PubMed GONUTS page
  2. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  3. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  4. 4.0 4.1 Wilson, SA et al. (1999) Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix. Biochem. J. 342 ( Pt 1) 97-103 PubMed GONUTS page
  5. 5.0 5.1 Lee, JH et al. (1999) Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. Proc. Natl. Acad. Sci. U.S.A. 96 4342-7 PubMed GONUTS page
  6. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page