GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:IF2P
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | EIF5B (synonyms: IF2, KIAA0741) | |
| Protein Name(s) | Eukaryotic translation initiation factor 5B
eIF-5B Translation initiation factor IF-2 | |
| External Links | ||
| UniProt | O60841 | |
| EMBL | AJ006776 AF078035 AC018690 AC079447 AB018284 AL133563 AJ006412 | |
| CCDS | CCDS42721.1 | |
| PIR | T43483 | |
| RefSeq | NP_056988.3 | |
| UniGene | Hs.158688 | |
| ProteinModelPortal | O60841 | |
| SMR | O60841 | |
| BioGrid | 115024 | |
| IntAct | O60841 | |
| MINT | MINT-3000520 | |
| STRING | 9606.ENSP00000289371 | |
| PhosphoSite | O60841 | |
| MaxQB | O60841 | |
| PaxDb | O60841 | |
| PRIDE | O60841 | |
| Ensembl | ENST00000289371 | |
| GeneID | 9669 | |
| KEGG | hsa:9669 | |
| UCSC | uc002tab.3 | |
| CTD | 9669 | |
| GeneCards | GC02P099953 | |
| H-InvDB | HIX0002308 | |
| HGNC | HGNC:30793 | |
| HPA | HPA034648 HPA040095 | |
| MIM | 606086 | |
| neXtProt | NX_O60841 | |
| PharmGKB | PA134864457 | |
| eggNOG | COG0532 | |
| GeneTree | ENSGT00730000111064 | |
| HOGENOM | HOG000105770 | |
| HOVERGEN | HBG019036 | |
| InParanoid | O60841 | |
| KO | K03243 | |
| OMA | GSLRMHT | |
| OrthoDB | EOG7034GC | |
| PhylomeDB | O60841 | |
| TreeFam | TF101535 | |
| Reactome | REACT_2085 | |
| ChiTaRS | EIF5B | |
| GeneWiki | EIF5B | |
| GenomeRNAi | 9669 | |
| NextBio | 36307 | |
| PMAP-CutDB | O60841 | |
| PRO | PR:O60841 | |
| Proteomes | UP000005640 | |
| Bgee | O60841 | |
| CleanEx | HS_EIF5B | |
| ExpressionAtlas | O60841 | |
| Genevestigator | O60841 | |
| GO | GO:0005829 GO:0005525 GO:0003924 GO:0044822 GO:0003743 GO:0044267 GO:0010467 GO:0006446 GO:0006412 GO:0006413 | |
| Gene3D | 3.40.50.10050 3.40.50.300 | |
| InterPro | IPR000795 IPR029459 IPR027417 IPR005225 IPR023115 IPR009000 IPR004161 | |
| Pfam | PF00009 PF03144 PF14578 PF11987 | |
| PRINTS | PR00315 | |
| SUPFAM | SSF50447 SSF52156 SSF52540 | |
| TIGRFAMs | TIGR00231 | |
| PROSITE | PS51722 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
NOT|part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000561881 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003924 |
GTPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-72672 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bohnsack, MT et al. (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 21 6205-15 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ 4.0 4.1 Wilson, SA et al. (1999) Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix. Biochem. J. 342 ( Pt 1) 97-103 PubMed GONUTS page
- ↑ 5.0 5.1 Lee, JH et al. (1999) Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. Proc. Natl. Acad. Sci. U.S.A. 96 4342-7 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
