HUMAN:IDHC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IDH1 (synonyms: PICD)
Protein Name(s)	Isocitrate dehydrogenase [NADP] cytoplasmic IDH Cytosolic NADP-isocitrate dehydrogenase IDP NADP(+)-specific ICDH Oxalosuccinate decarboxylase
External Links
UniProt	O75874
EMBL	AF020038 AF113917 AL136702 CR541695 BX537411 AC016697 CH471063 BC012846 BC093020 U62389
CCDS	CCDS2381.1
PIR	T46280
RefSeq	NP_001269315.1 NP_001269316.1 NP_005887.2
UniGene	Hs.593422
PDB	1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06
PDBsum	1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06
ProteinModelPortal	O75874
SMR	O75874
BioGrid	109643
DIP	DIP-59311N
IntAct	O75874
MINT	MINT-4998878
STRING	9606.ENSP00000260985
BindingDB	O75874
ChEMBL	CHEMBL2007625
PhosphoSite	O75874
OGP	O75874
REPRODUCTION-2DPAGE	IPI00027223
UCD-2DPAGE	O75874
MaxQB	O75874
PaxDb	O75874
PeptideAtlas	O75874
PRIDE	O75874
DNASU	3417
Ensembl	ENST00000345146 ENST00000415913 ENST00000446179
GeneID	3417
KEGG	hsa:3417
UCSC	uc002vcs.3
CTD	3417
GeneCards	GC02M209100
H-InvDB	HIX0161877
HGNC	HGNC:5382
HPA	CAB033218 CAB062556 HPA035248 HPA057936
MIM	137800 147700
neXtProt	NX_O75874
Orphanet	296 251579 251576 163634 99646
PharmGKB	PA29630
eggNOG	COG0538
HOGENOM	HOG000019858
HOVERGEN	HBG006119
InParanoid	O75874
KO	K00031
OMA	HNFESCG
OrthoDB	EOG7QNVKS
PhylomeDB	O75874
TreeFam	TF300428
BioCyc	MetaCyc:HS06502-MONOMER
Reactome	REACT_160183 REACT_16904
SABIO-RK	O75874
ChiTaRS	IDH1
EvolutionaryTrace	O75874
GeneWiki	IDH1
GenomeRNAi	3417
NextBio	13470
PRO	PR:O75874
Proteomes	UP000005640
Bgee	O75874
CleanEx	HS_IDH1
ExpressionAtlas	O75874
Genevestigator	O75874
GO	GO:0005737 GO:0005829 GO:0070062 GO:0005739 GO:0005782 GO:0005777 GO:0004450 GO:0000287 GO:0051287 GO:0050661 GO:0042803 GO:0005102 GO:0006103 GO:0044255 GO:0008585 GO:0006749 GO:0006097 GO:0006102 GO:0006740 GO:0006979 GO:0048545 GO:0044281 GO:0006099
Gene3D	3.40.718.10
InterPro	IPR019818 IPR004790 IPR024084
PANTHER	PTHR11822
Pfam	PF00180
PIRSF	PIRSF000108
TIGRFAMs	TIGR00127
PROSITE	PS00470

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0045296	cadherin binding	PMID:25468996^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19935646^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75874	F		Seeded From UniProt	complete
involved_in	GO:0006103	2-oxoglutarate metabolic process	PMID:19935646^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006102	isocitrate metabolic process	PMID:10521434^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006102	isocitrate metabolic process	PMID:20171178^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006102	isocitrate metabolic process	PMID:19935646^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10521434^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:10521434^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:20178365^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P50542	F		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	PMID:10521434^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	PMID:20171178^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	PMID:19935646^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:19935646^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006739	NADP metabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000214400 TAIR:locus:2009759	P		Seeded From UniProt	complete
involved_in	GO:0006102	isocitrate metabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000214400 RGD:2862 SGD:S000004164 TAIR:locus:2009759 UniProtKB:O75874 UniProtKB:P9WKL1	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96413 PANTHER:PTN000930158 UniProtKB:O75874	C		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930158 RGD:2862 UniProtKB:O75874	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001248 MGI:MGI:96413 PANTHER:PTN000214284 SGD:S000002224 TAIR:locus:2222672 UniProtKB:C8VIX5	C		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96413 MGI:MGI:96414 PANTHER:PTN000214400 RGD:1597139 RGD:2862 SGD:S000002224 SGD:S000004164 SGD:S000004954 TAIR:locus:2009759 UniProtKB:O75874 UniProtKB:P48735 UniProtKB:P9WKL1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26436839^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75874	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21516116^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75874	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19935646^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O75874	F		Seeded From UniProt	complete
involved_in	GO:0071071	regulation of phospholipid biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	P		Seeded From UniProt	complete
involved_in	GO:0060696	regulation of phospholipid catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	P		Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	C		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	F		Seeded From UniProt	complete
enables	GO:0004448	isocitrate dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O88844 ensembl:ENSMUSP00000095316	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	F		Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	P		Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	P		Seeded From UniProt	complete
involved_in	GO:0006102	isocitrate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	P		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	C		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P41562 ensembl:ENSRNOP00000020322	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019818	F		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004790	F		Seeded From UniProt	complete
involved_in	GO:0006102	isocitrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004790	P		Seeded From UniProt	complete
enables	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019818 InterPro:IPR024084	F		Seeded From UniProt	complete
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019818	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004790 InterPro:IPR019818 InterPro:IPR024084	P		Seeded From UniProt	complete
enables	GO:0004450	isocitrate dehydrogenase (NADP+) activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.42	F		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1904724	tertiary granule lumen	Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006740	NADPH regeneration	Reactome:R-HSA-389542	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006625	protein targeting to peroxisome	Reactome:R-HSA-9033241	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006103	2-oxoglutarate metabolic process	Reactome:R-HSA-2978092	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9033236 Reactome:R-HSA-9033235 Reactome:R-HSA-880053 Reactome:R-HSA-389540	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005782	peroxisomal matrix	Reactome:R-HSA-9033235 Reactome:R-HSA-389550	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748 Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006097	glyoxylate cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0329	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006099	tricarboxylic acid cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0816	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0576 UniProtKB-SubCell:SL-0204	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Dang, L et al. (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462 739-44 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Geisbrecht, BV & Gould, SJ (1999) The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. J. Biol. Chem. 274 30527-33 PubMed GONUTS page
↑ ^6.0 ^6.1 Murugan, AK et al. (2010) Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer. Biochem. Biophys. Res. Commun. 393 555-9 PubMed GONUTS page
↑ Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Okoye-Okafor, UC et al. (2015) New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat. Chem. Biol. 11 878-86 PubMed GONUTS page
↑ Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page

[PMID:25468996-1] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:19935646-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Dang, L et al. (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462 739-44 PubMed GONUTS page

[PMID:10521434-5] 5.0 ^5.1 ^5.2 ^5.3 Geisbrecht, BV & Gould, SJ (1999) The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. J. Biol. Chem. 274 30527-33 PubMed GONUTS page

[PMID:20171178-6] 6.0 ^6.1 Murugan, AK et al. (2010) Identification and functional characterization of isocitrate dehydrogenase 1 (IDH1) mutations in thyroid cancer. Biochem. Biophys. Res. Commun. 393 555-9 PubMed GONUTS page

[PMID:20178365-7] Ghosh, D & Berg, JM (2010) A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities. J. Am. Chem. Soc. 132 3973-9 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26436839-9] Okoye-Okafor, UC et al. (2015) New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat. Chem. Biol. 11 878-86 PubMed GONUTS page

[PMID:21516116-10] Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page

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HUMAN:IDHC

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