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HUMAN:HXA1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | HOXA1 (synonyms: HOX1F) | |
Protein Name(s) | Homeobox protein Hox-A1
Homeobox protein Hox-1F | |
External Links | ||
UniProt | P49639 | |
EMBL | U10421 AK313514 AC004079 CH236948 CH471073 BC032547 U37431 U37431 U37431 S79869 S79871 S79910 | |
CCDS | CCDS5401.1 CCDS5402.2 | |
PIR | G01448 | |
RefSeq | NP_005513.1 NP_705873.2 | |
UniGene | Hs.67397 | |
ProteinModelPortal | P49639 | |
SMR | P49639 | |
BioGrid | 109438 | |
IntAct | P49639 | |
MINT | MINT-1437157 | |
STRING | 9606.ENSP00000343246 | |
PhosphoSite | P49639 | |
DMDM | 6166216 | |
PaxDb | P49639 | |
PRIDE | P49639 | |
DNASU | 3198 | |
Ensembl | ENST00000343060 | |
GeneID | 3198 | |
KEGG | hsa:3198 | |
UCSC | uc003syd.3 uc003sye.3 uc022aao.1 | |
CTD | 3198 | |
GeneCards | GC07M027099 | |
HGNC | HGNC:5099 | |
HPA | HPA004933 | |
MIM | 142955 601536 | |
neXtProt | NX_P49639 | |
Orphanet | 69739 69737 | |
PharmGKB | PA29376 | |
eggNOG | NOG236971 | |
GeneTree | ENSGT00760000118940 | |
HOGENOM | HOG000247020 | |
HOVERGEN | HBG006089 | |
InParanoid | P49639 | |
KO | K09301 | |
OrthoDB | EOG7PK91P | |
PhylomeDB | P49639 | |
TreeFam | TF317730 | |
GeneWiki | Homeobox_A1 | |
GenomeRNAi | 3198 | |
NextBio | 12718 | |
PRO | PR:P49639 | |
Proteomes | UP000005640 | |
Bgee | P49639 | |
CleanEx | HS_HOXA1 | |
ExpressionAtlas | P49639 | |
Genevestigator | P49639 | |
GO | GO:0005634 GO:0043565 GO:0021599 GO:0009653 GO:0009952 GO:0060840 GO:0048844 GO:0021953 GO:0090102 GO:0090103 GO:0050890 GO:0048702 GO:0021612 GO:0021754 GO:0048839 GO:0008045 GO:0007275 GO:0050905 GO:0007634 GO:0042473 GO:0045944 GO:0050795 GO:0021569 GO:0021570 GO:0021571 GO:0060876 GO:0007605 GO:0006351 | |
Gene3D | 1.10.10.60 | |
InterPro | IPR017970 IPR001356 IPR020479 IPR009057 | |
Pfam | PF00046 | |
PRINTS | PR00024 | |
SMART | SM00389 | |
SUPFAM | SSF46689 | |
PROSITE | PS00027 PS50071 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000305 |
curator inference used in manual assertion |
GO:0043565,GO:0045944 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_regulation_target:(NCBI_Gene:595) |
Seeded From UniProt |
complete | ||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090103 |
cochlea morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090102 |
cochlea development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060876 |
semicircular canal formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060840 |
artery development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050905 |
neuromuscular process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050890 |
cognition |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050795 |
regulation of behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048844 |
artery morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048839 |
inner ear development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048702 |
embryonic neurocranium morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042473 |
outer ear morphogenesis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0021599 |
abducens nerve formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009653 |
anatomical structure morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007634 |
optokinetic behavior |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007605 |
sensory perception of sound |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Zhu, T et al. (2005) Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res. 65 317-24 PubMed GONUTS page
- ↑ Jolma, A et al. (2013) DNA-binding specificities of human transcription factors. Cell 152 327-39 PubMed GONUTS page
- ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 Tischfield, MA et al. (2005) Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. Nat. Genet. 37 1035-7 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page
- ↑ Hong, YS et al. (1995) Structure and function of the HOX A1 human homeobox gene cDNA. Gene 159 209-14 PubMed GONUTS page
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