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HUMAN:HXA1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HOXA1 (synonyms: HOX1F)
Protein Name(s) Homeobox protein Hox-A1

Homeobox protein Hox-1F

External Links
UniProt P49639
EMBL U10421
AK313514
AC004079
CH236948
CH471073
BC032547
U37431
U37431
U37431
S79869
S79871
S79910
CCDS CCDS5401.1
CCDS5402.2
PIR G01448
RefSeq NP_005513.1
NP_705873.2
UniGene Hs.67397
ProteinModelPortal P49639
SMR P49639
BioGrid 109438
IntAct P49639
MINT MINT-1437157
STRING 9606.ENSP00000343246
PhosphoSite P49639
DMDM 6166216
PaxDb P49639
PRIDE P49639
DNASU 3198
Ensembl ENST00000343060
GeneID 3198
KEGG hsa:3198
UCSC uc003syd.3
uc003sye.3
uc022aao.1
CTD 3198
GeneCards GC07M027099
HGNC HGNC:5099
HPA HPA004933
MIM 142955
601536
neXtProt NX_P49639
Orphanet 69739
69737
PharmGKB PA29376
eggNOG NOG236971
GeneTree ENSGT00760000118940
HOGENOM HOG000247020
HOVERGEN HBG006089
InParanoid P49639
KO K09301
OrthoDB EOG7PK91P
PhylomeDB P49639
TreeFam TF317730
GeneWiki Homeobox_A1
GenomeRNAi 3198
NextBio 12718
PRO PR:P49639
Proteomes UP000005640
Bgee P49639
CleanEx HS_HOXA1
ExpressionAtlas P49639
Genevestigator P49639
GO GO:0005634
GO:0043565
GO:0021599
GO:0009653
GO:0009952
GO:0060840
GO:0048844
GO:0021953
GO:0090102
GO:0090103
GO:0050890
GO:0048702
GO:0021612
GO:0021754
GO:0048839
GO:0008045
GO:0007275
GO:0050905
GO:0007634
GO:0042473
GO:0045944
GO:0050795
GO:0021569
GO:0021570
GO:0021571
GO:0060876
GO:0007605
GO:0006351
Gene3D 1.10.10.60
InterPro IPR017970
IPR001356
IPR020479
IPR009057
Pfam PF00046
PRINTS PR00024
SMART SM00389
SUPFAM SSF46689
PROSITE PS00027
PS50071

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:P20263

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000036

ECO:0000305

curator inference used in manual assertion

GO:0043565,GO:0045944

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:15665309[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:595)

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:23332764[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090103

cochlea morphogenesis

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090102

cochlea development

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060876

semicircular canal formation

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060840

artery development

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050905

neuromuscular process

PMID:16155570[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050890

cognition

PMID:16155570[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050795

regulation of behavior

PMID:16155570[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048844

artery morphogenesis

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048839

inner ear development

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048702

embryonic neurocranium morphogenesis

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042473

outer ear morphogenesis

PMID:16155570[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021599

abducens nerve formation

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:16155570[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007634

optokinetic behavior

PMID:16155570[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

PMID:16155570[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49639

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:21516116[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P49639

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057
InterPro:IPR020479

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

PMID:7622051[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. Zhu, T et al. (2005) Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res. 65 317-24 PubMed GONUTS page
  3. Jolma, A et al. (2013) DNA-binding specificities of human transcription factors. Cell 152 327-39 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 Tischfield, MA et al. (2005) Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development. Nat. Genet. 37 1035-7 PubMed GONUTS page
  5. Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  6. Yu, H et al. (2011) Next-generation sequencing to generate interactome datasets. Nat. Methods 8 478-80 PubMed GONUTS page
  7. Hong, YS et al. (1995) Structure and function of the HOX A1 human homeobox gene cDNA. Gene 159 209-14 PubMed GONUTS page