HUMAN:HSPB1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HSPB1 (synonyms: HSP27, HSP28)
Protein Name(s)	Heat shock protein beta-1 HspB1 28 kDa heat shock protein Estrogen-regulated 24 kDa protein Heat shock 27 kDa protein HSP 27 Stress-responsive protein 27 SRP27
External Links
UniProt	P04792
EMBL	L39370 X54079 Z23090 AB020027 U90906 CR407614 CR536489 BT019888 AK311894 DQ379985 AC006388 CH471220 BC000510 BC012292 BC012768 BC014920 BC073768 X16477 S74571
CCDS	CCDS5583.1
PIR	S12102
RefSeq	NP_001531.1
UniGene	Hs.520973
PDB	3Q9P 3Q9Q 4MJH
PDBsum	3Q9P 3Q9Q 4MJH
ProteinModelPortal	P04792
SMR	P04792
BioGrid	109547
DIP	DIP-412N
IntAct	P04792
MINT	MINT-1368692
BindingDB	P04792
ChEMBL	CHEMBL5976
PhosphoSite	P04792
DMDM	19855073
DOSAC-COBS-2DPAGE	P04792
OGP	P04792
REPRODUCTION-2DPAGE	IPI00025512 P04792
SWISS-2DPAGE	P04792
UCD-2DPAGE	P04792
MaxQB	P04792
PaxDb	P04792
PeptideAtlas	P04792
PRIDE	P04792
DNASU	3315
Ensembl	ENST00000248553
GeneID	3315
KEGG	hsa:3315
UCSC	uc003uew.3
CTD	3315
GeneCards	GC07P075931
GeneReviews	HSPB1
HGNC	HGNC:5246
HPA	CAB004439 CAB047330 CAB047331 CAB047332 HPA000497
MIM	602195 606595 608634
neXtProt	NX_P04792
Orphanet	99940 139525
PharmGKB	PA29511
eggNOG	NOG307785
HOVERGEN	HBG054766
InParanoid	P04792
KO	K04455
OMA	HTSDRWR
OrthoDB	EOG7WHHBK
PhylomeDB	P04792
TreeFam	TF105049
Reactome	REACT_228166 REACT_25325
ChiTaRS	HSPB1
GeneWiki	Hsp27
GenomeRNAi	3315
NextBio	13148
PRO	PR:P04792
Proteomes	UP000005640
Bgee	P04792
CleanEx	HS_HSPB1
ExpressionAtlas	P04792
Genevestigator	P04792
GO	GO:0005737 GO:0005856 GO:0005829 GO:0005615 GO:0070062 GO:0005925 GO:0005634 GO:0005886 GO:0000502 GO:0005819 GO:0030018 GO:0042802 GO:0044822 GO:0019901 GO:0005080 GO:0008426 GO:0043130 GO:0006928 GO:0035924 GO:0010467 GO:0035556 GO:0016071 GO:0043066 GO:1902176 GO:0006469 GO:0070527 GO:0045766 GO:0043536 GO:2001028 GO:0038033 GO:0032731 GO:0042535 GO:0043122 GO:0006446 GO:0006986 GO:0009615 GO:0001895 GO:0016070
Gene3D	2.60.40.790
InterPro	IPR002068 IPR001436 IPR008978
Pfam	PF00011
PIRSF	PIRSF036514
PRINTS	PR00299
SUPFAM	SSF49764
PROSITE	PS01031

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046596	regulation of viral entry into host cell	PMID:24098578^[1]	ECO:0000314			P		Figure 1	complete CACAO 8960
involved_in	GO:0010506	regulation of autophagy	PMID:25962073^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:28144995^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:28144995^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20178975^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044183	protein folding chaperone	PMID:20178975^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	PMID:20178975^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070527	platelet aggregation	PMID:23382103^[6]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	PMID:23580065^[10]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099641	anterograde axonal protein transport	PMID:23728742^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:23728742^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23948568^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	PMID:23948568^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001028	positive regulation of endothelial cell chemotaxis	PMID:18440775^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:18440775^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	PMID:18440775^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42930	F		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	P		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	P		Seeded From UniProt	complete
involved_in	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	PMID:18440775^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:18440775^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:18440775^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	P		Seeded From UniProt	complete
enables	GO:0008426	protein kinase C inhibitor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	F		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	P		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P14602	F		Seeded From UniProt	complete
part_of	GO:0000502	proteasome complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P42930	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8774846^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16644	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:8774846^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49137	F		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:16548883^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:1560006^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19464326^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19464326^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25277244^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04792	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25036637^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04792	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22365833^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04792	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11003656^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04792	F		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008426	P		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008426	P		Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0099641	C		Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	P		Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	P		Seeded From UniProt	complete
part_of	GO:0043292	contractile fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	C		Seeded From UniProt	complete
involved_in	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	P		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	P		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	C		Seeded From UniProt	complete
enables	GO:0008426	protein kinase C inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	F		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	C		Seeded From UniProt	complete
enables	GO:0005080	protein kinase C binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14602 ensembl:ENSMUSP00000005077	F		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	PMID:10859165^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006446	regulation of translational initiation	PMID:10859165^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10859165^[24] PMID:16130169^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16130169^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:16130169^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450408	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5687121 Reactome:R-HSA-5218916 Reactome:R-HSA-450580 Reactome:R-HSA-450551	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Tsou, YL et al. (2013) Heat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapy. PLoS ONE 8 e77133 PubMed GONUTS page
↑ Matsumoto, T et al. (2015) Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury. PLoS ONE 10 e0126229 PubMed GONUTS page
↑ ^3.0 ^3.1 Echaniz-Laguna, A et al. (2017) Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations. Hum. Mutat. 38 556-568 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Almeida-Souza, L et al. (2010) Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy. J. Biol. Chem. 285 12778-86 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Fröbel, J et al. (2013) Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol. Cell Proteomics 12 1272-80 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^10.0 ^10.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ ^12.0 ^12.1 Holmgren, A et al. (2013) Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments. Acta Neuropathol. 126 93-108 PubMed GONUTS page
↑ ^13.0 ^13.1 Nefedova, VV et al. (2013) Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy. Arch. Biochem. Biophys. 538 16-24 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^16.0 ^16.1 Clifton, AD et al. (1996) A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett. 392 209-14 PubMed GONUTS page
↑ Leong, WF & Chow, VT (2006) Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell. Microbiol. 8 565-80 PubMed GONUTS page
↑ Kato, K et al. (1992) Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle. J. Biol. Chem. 267 7718-25 PubMed GONUTS page
↑ ^19.0 ^19.1 Vos, MJ et al. (2009) HSPB7 is a SC35 speckle resident small heat shock protein. Biochim. Biophys. Acta 1793 1343-53 PubMed GONUTS page
↑ Katsogiannou, M et al. (2014) The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Mol. Cell Proteomics 13 3585-601 PubMed GONUTS page
↑ Taipale, M et al. (2014) A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell 158 434-48 PubMed GONUTS page
↑ Hegele, A et al. (2012) Dynamic protein-protein interaction wiring of the human spliceosome. Mol. Cell 45 567-80 PubMed GONUTS page
↑ Charette, SJ et al. (2000) Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell. Biol. 20 7602-12 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Cuesta, R et al. (2000) Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. Genes Dev. 14 1460-70 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page

[PMID:24098578-1] Tsou, YL et al. (2013) Heat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapy. PLoS ONE 8 e77133 PubMed GONUTS page

[PMID:25962073-2] Matsumoto, T et al. (2015) Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and Regulates Autophagy and Apoptosis of Renal Tubular Cells in Acute Kidney Injury. PLoS ONE 10 e0126229 PubMed GONUTS page

[PMID:28144995-3] 3.0 ^3.1 Echaniz-Laguna, A et al. (2017) Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations. Hum. Mutat. 38 556-568 PubMed GONUTS page

[PMID:20178975-4] 4.0 ^4.1 ^4.2 Almeida-Souza, L et al. (2010) Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy. J. Biol. Chem. 285 12778-86 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:23382103-6] Fröbel, J et al. (2013) Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol. Cell Proteomics 12 1272-80 PubMed GONUTS page

[PMID:21423176-7] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19199708-8] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-9] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:23580065-10] 10.0 ^10.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:22664934-11] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:23728742-12] 12.0 ^12.1 Holmgren, A et al. (2013) Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments. Acta Neuropathol. 126 93-108 PubMed GONUTS page

[PMID:23948568-13] 13.0 ^13.1 Nefedova, VV et al. (2013) Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy. Arch. Biochem. Biophys. 538 16-24 PubMed GONUTS page

[PMID:18440775-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Evans, IM et al. (2008) Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase. Cell. Signal. 20 1375-84 PubMed GONUTS page

[PMID:22658674-15] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:8774846-16] 16.0 ^16.1 Clifton, AD et al. (1996) A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett. 392 209-14 PubMed GONUTS page

[PMID:16548883-17] Leong, WF & Chow, VT (2006) Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell. Microbiol. 8 565-80 PubMed GONUTS page

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HUMAN:HSPB1

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