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HUMAN:HPT

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HP
Protein Name(s) Haptoglobin

Zonulin Haptoglobin alpha chain Haptoglobin beta chain

External Links
UniProt P00738
EMBL K00422
K01763
L29394
X00637
X01793
X01786
X02206
X01789
X01791
M10935
M69197
AK314700
DQ314870
AC004682
AC009087
BC107587
BC121124
BC121125
M13192
X00606
CCDS CCDS45524.1
CCDS45525.1
PIR A92532
A93521
RefSeq NP_001119574.1
NP_005134.1
UniGene Hs.513711
Hs.702099
ProteinModelPortal P00738
SMR P00738
BioGrid 109480
IntAct P00738
STRING 9606.ENSP00000348170
MEROPS S01.972
PhosphoSite P00738
DMDM 123508
DOSAC-COBS-2DPAGE P00738
SWISS-2DPAGE P00738
MaxQB P00738
PaxDb P00738
PRIDE P00738
DNASU 3240
Ensembl ENST00000355906
ENST00000398131
ENST00000565574
ENST00000570083
GeneID 3240
KEGG hsa:3240
UCSC uc002fbr.4
uc002fbt.5
CTD 3240
GeneCards GC16P072089
HGNC HGNC:5141
HPA CAB003787
HPA047750
MIM 140100
614081
neXtProt NX_P00738
PharmGKB PA29415
eggNOG NOG246387
GeneTree ENSGT00760000118890
HOVERGEN HBG005989
InParanoid P00738
KO K16142
OrthoDB EOG722J8R
PhylomeDB P00738
TreeFam TF334326
Reactome REACT_160163
GeneWiki Haptoglobin
GenomeRNAi 3240
NextBio 12895
PRO PR:P00738
Proteomes UP000005640
Bgee P00738
CleanEx HS_HP
ExpressionAtlas P00738
Genevestigator P00738
GO GO:0072562
GO:0071682
GO:0005576
GO:0005615
GO:0070062
GO:0031838
GO:0016209
GO:0003824
GO:0030492
GO:0006953
GO:0006952
GO:0042742
GO:0002376
GO:2000296
GO:0051354
GO:0010942
GO:0042542
InterPro IPR001254
IPR001314
IPR000436
IPR009003
Pfam PF00089
PRINTS PR00722
SMART SM00032
SM00020
SUPFAM SSF50494
SSF57535
PROSITE PS50923
PS50240

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0030492

hemoglobin binding

PMID:19740759[1]

ECO:0000314

F

Fig 2 shows haemoglobin-haptoglobin complexes and how EPR signal varies compared to pure haemoglobin.

complete

GO:0031838

haptoglobin-hemoglobin complex

PMID:19740759[1]

ECO:0000314

C

Fig 2 shows haemoglobin-haptoglobin complexes and how EPR signal varies compared to pure haemoglobin.

complete

Contributes to

GO:0004601

peroxidase activity

PMID:19740759[1]

ECO:0000314

F

Fig 5 shows positive peroxidase activity of haemoglobin-haptoglobin complexes.

complete

Contributes to

GO:0042542

response to hydrogen peroxide

PMID:19740759[1]

ECO:0000314

P

Fig 3: large MW aggregates can be seen after addition of hydrogen peroxide when both haemoglobin and haptoglobin are present.

complete

part_of

GO:0005615

extracellular space

PMID:21805676[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:25645918[3]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0007311)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0072562

blood microparticle

PMID:22516433[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22664934[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

involved_in

GO:2000296

negative regulation of hydrogen peroxide catabolic process

PMID:19740759[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051354

negative regulation of oxidoreductase activity

PMID:19740759[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042542

response to hydrogen peroxide

PMID:19740759[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031838

haptoglobin-hemoglobin complex

PMID:19740759[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030492

hemoglobin binding

PMID:19740759[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

PMID:19740759[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[9]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000667778
UniProtKB:P00738

P

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000667778
RGD:2825

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2660692
MGI:MGI:88492
PANTHER:PTN001207255
RGD:2825
RGD:620213
UniProtKB:P00736
UniProtKB:P00738
UniProtKB:P48740

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88492
PANTHER:PTN001207255
RGD:620213
RGD:620214
UniProtKB:O00187
UniProtKB:P00736
UniProtKB:P09871
UniProtKB:P48740

F

Seeded From UniProt

complete

involved_in

GO:0002526

acute inflammatory response

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000667778
RGD:2825

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19433579[11]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004252

P

Seeded From UniProt

complete

involved_in

GO:0098869

cellular oxidant detoxification

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016209

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008292

C

Seeded From UniProt

complete

enables

GO:0030492

hemoglobin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008292

F

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

PMID:7036344[12]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1904724

tertiary granule lumen

Reactome:R-HSA-6798745

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071682

endocytic vesicle lumen

Reactome:R-HSA-2230938

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035580

specific granule lumen

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006898

receptor-mediated endocytosis

Reactome:R-HSA-2173782

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798749
Reactome:R-HSA-6798745
Reactome:R-HSA-2230938
Reactome:R-HSA-2168885
Reactome:R-HSA-2168883

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0049

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0044

P

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0011

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0030492

hemoglobin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0351

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Kapralov, A et al. (2009) Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages. J. Biol. Chem. 284 30395-407 PubMed GONUTS page
  2. ↑ Fornander, L et al. (2011) Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Proteomics Clin Appl 5 513-22 PubMed GONUTS page
  3. ↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
  4. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  5. ↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
  6. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  7. ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  8. ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  9. ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  11. ↑ Watanabe, J et al. (2009) Hemoglobin and its scavenger protein haptoglobin associate with apoA-1-containing particles and influence the inflammatory properties and function of high density lipoprotein. J. Biol. Chem. 284 18292-301 PubMed GONUTS page
  12. ↑ Eaton, JW et al. (1982) Haptoglobin: a natural bacteriostat. Science 215 691-3 PubMed GONUTS page
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