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HUMAN:HNRPK
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | HNRNPK (synonyms: HNRPK) | |
| Protein Name(s) | Heterogeneous nuclear ribonucleoprotein K
hnRNP K Transformation up-regulated nuclear protein TUNP | |
| External Links | ||
| UniProt | P61978 | |
| EMBL | S74678 X72727 AB209562 AL354733 CH471089 BC000355 BC014980 | |
| CCDS | CCDS6667.1 CCDS6668.1 | |
| PIR | S43363 | |
| RefSeq | NP_002131.2 NP_112552.1 NP_112553.1 XP_005252017.1 XP_005252018.1 XP_005252020.1 XP_005252021.1 XP_005252022.1 | |
| UniGene | Hs.522257 | |
| PDB | 1J5K 1KHM 1ZZI 1ZZJ 1ZZK | |
| PDBsum | 1J5K 1KHM 1ZZI 1ZZJ 1ZZK | |
| ProteinModelPortal | P61978 | |
| SMR | P61978 | |
| BioGrid | 109431 | |
| DIP | DIP-31805N | |
| IntAct | P61978 | |
| MINT | MINT-225422 | |
| STRING | 9606.ENSP00000365439 | |
| PhosphoSite | P61978 | |
| DMDM | 48429103 | |
| SWISS-2DPAGE | P61978 | |
| MaxQB | P61978 | |
| PaxDb | P61978 | |
| PRIDE | P61978 | |
| DNASU | 3190 | |
| Ensembl | ENST00000351839 ENST00000360384 ENST00000376263 ENST00000376281 | |
| GeneID | 3190 | |
| KEGG | hsa:3190 | |
| UCSC | uc004ang.4 uc004anh.4 | |
| CTD | 3190 | |
| GeneCards | GC09M086582 | |
| HGNC | HGNC:5044 | |
| HPA | CAB004435 CAB016225 HPA007644 HPA044105 | |
| MIM | 600712 | |
| neXtProt | NX_P61978 | |
| PharmGKB | PA162391350 | |
| eggNOG | NOG285495 | |
| GeneTree | ENSGT00760000119144 | |
| HOVERGEN | HBG051916 | |
| InParanoid | P61978 | |
| KO | K12886 | |
| OMA | KALRTDX | |
| OrthoDB | EOG7CZK81 | |
| PhylomeDB | P61978 | |
| TreeFam | TF316335 | |
| Reactome | REACT_125 REACT_467 | |
| ChiTaRS | HNRNPK | |
| EvolutionaryTrace | P61978 | |
| GeneWiki | HNRPK | |
| GenomeRNAi | 3190 | |
| NextBio | 12686 | |
| PMAP-CutDB | P61978 | |
| PRO | PR:P61978 | |
| Proteomes | UP000005640 | |
| Bgee | P61978 | |
| CleanEx | HS_HNRNPK | |
| ExpressionAtlas | P61978 | |
| Genevestigator | P61978 | |
| GO | GO:0071013 GO:0042995 GO:0005737 GO:0070062 GO:0005925 GO:0016020 GO:0000790 GO:0005654 GO:0005634 GO:0002102 GO:0044822 GO:0003723 GO:0000978 GO:0001077 GO:0003697 GO:0010467 GO:0000398 GO:0045716 GO:0048260 GO:0045944 GO:0072369 GO:0010988 GO:0006396 GO:0008380 GO:0007165 GO:0016032 | |
| Gene3D | 3.30.1370.10 | |
| InterPro | IPR004087 IPR004088 IPR012987 | |
| Pfam | PF00013 PF08067 | |
| SMART | SM00322 | |
| SUPFAM | SSF54791 | |
| PROSITE | PS50084 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Figure 3. Strong nuclear and cytoplasmic staining in primary and colorectal cancer. |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 3. Strong nuclear and cytoplasmic staining in primary colorectal cancer. |
complete | |||||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
exists_during:(GO:0034599) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019904 |
protein domain specific binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005925 |
focal adhesion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0072369 |
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048260 |
positive regulation of receptor-mediated endocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045716 |
positive regulation of low-density lipoprotein particle receptor biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010988 |
regulation of low-density lipoprotein particle clearance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000790 |
nuclear chromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0071013 |
catalytic step 2 spliceosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
ECO:0000305 |
curator inference used in manual assertion |
GO:0071013 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902165 |
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61979 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61979 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61979 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61979 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P61979 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006396 |
RNA processing |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016070 |
RNA metabolic process |
Reactome:R-HSA-8953854 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-72160 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0000398 |
mRNA splicing, via spliceosome |
Reactome:R-HSA-72163 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005681 |
spliceosomal complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030054 |
cell junction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042995 |
cell projection |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0002102 |
podosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Carpenter, B et al. (2006) Heterogeneous nuclear ribonucleoprotein K is over expressed, aberrantly localised and is associated with poor prognosis in colorectal cancer. Br. J. Cancer 95 921-7 PubMed GONUTS page
- ↑ Venables, JP et al. (2000) RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. Hum. Mol. Genet. 9 685-94 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 7.0 7.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Li, H & Liu, J (2010) Identification of heterogeneous nuclear ribonucleoprotein K as a transactivator for human low density lipoprotein receptor gene transcription. J. Biol. Chem. 285 17789-97 PubMed GONUTS page
- ↑ 9.0 9.1 Jurica, MS et al. (2002) Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA 8 426-39 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ White, MC et al. (2010) Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis via translocation of PKCdelta to mitochondria in spinocerebellar ataxia 10. PLoS Genet. 6 e1000984 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Hegele, A et al. (2012) Dynamic protein-protein interaction wiring of the human spliceosome. Mol. Cell 45 567-80 PubMed GONUTS page
- ↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Dejgaard, K et al. (1994) Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing. J. Mol. Biol. 236 33-48 PubMed GONUTS page
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- GO:0006357 ! regulation of transcription by RNA polymerase II
- GO:1902165 ! regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
- GO:0010988 ! regulation of low-density lipoprotein particle clearance
- GO:0003723 ! RNA binding
- GO:0016070 ! RNA metabolic process
- GO:0000978 ! RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0006396 ! RNA processing
- GO:0008380 ! RNA splicing
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