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HUMAN:HEXI1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) HEXIM1 (synonyms: CLP1, EDG1, HIS1, MAQ1)
Protein Name(s) Protein HEXIM1

Cardiac lineage protein 1 Estrogen down-regulated gene 1 protein Hexamethylene bis-acetamide-inducible protein 1 Menage a quatre protein 1

External Links
UniProt O94992
EMBL AB021179
AK313557
BC006460
CCDS CCDS11495.1
RefSeq NP_006451.1
UniGene Hs.586945
Hs.741758
Hs.745252
PDB 2GD7
3S9G
PDBsum 2GD7
3S9G
ProteinModelPortal O94992
SMR O94992
BioGrid 115860
DIP DIP-46463N
IntAct O94992
STRING 9606.ENSP00000328773
ChEMBL CHEMBL3120044
PhosphoSite O94992
MaxQB O94992
PaxDb O94992
PeptideAtlas O94992
PRIDE O94992
DNASU 10614
Ensembl ENST00000332499
GeneID 10614
KEGG hsa:10614
UCSC uc002iig.3
CTD 10614
GeneCards GC17P043224
HGNC HGNC:24953
HPA CAB011625
HPA008926
MIM 607328
neXtProt NX_O94992
PharmGKB PA142671694
eggNOG NOG72325
GeneTree ENSGT00390000002808
HOGENOM HOG000060338
HOVERGEN HBG053249
InParanoid O94992
KO K15189
OMA EDSRWQS
OrthoDB EOG771281
PhylomeDB O94992
TreeFam TF336851
ChiTaRS HEXIM1
EvolutionaryTrace O94992
GeneWiki HEXIM1
GenomeRNAi 10614
NextBio 40326
PRO PR:O94992
Proteomes UP000005640
Bgee O94992
CleanEx HS_CLP1
HS_HEXIM1
Genevestigator O94992
GO GO:0005737
GO:0005634
GO:0004861
GO:0017069
GO:0007507
GO:0045736
GO:0000122
GO:0045892
GO:0006351
InterPro IPR024872
PANTHER PTHR13469
Pfam PF15313
PRINTS PR02094

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1901798

positive regulation of signal transduction by p53 class mediator

PMID:22948151[1]

ECO:0000315

P

Fig 6.

complete
CACAO 6812

involved_in

GO:0002218

activation of innate immune response

PMID:28712728[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28712728[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0097322

7SK snRNA binding

PMID:19883659[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0097322

7SK snRNA binding

PMID:12832472[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1901798

positive regulation of signal transduction by p53 class mediator

PMID:22948151[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:14580347[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:14580347[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017069

snRNA binding

PMID:14580347[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12581153[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:12581153[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004861

cyclin-dependent protein serine/threonine kinase inhibitor activity

PMID:14580347[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:14580347[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0097322

7SK snRNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0038251
PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

F

Seeded From UniProt

complete

involved_in

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0038251
MGI:MGI:2385923
PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

C

Seeded From UniProt

complete

enables

GO:0004861

cyclin-dependent protein serine/threonine kinase inhibitor activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001003630
UniProtKB:O94992
UniProtKB:Q96MH2

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R409
ensembl:ENSMUSP00000057339

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R409
ensembl:ENSMUSP00000057339

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q8R409
ensembl:ENSMUSP00000057339

C

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024872

P

Seeded From UniProt

complete

enables

GO:0004861

cyclin-dependent protein serine/threonine kinase inhibitor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024872

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024872

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024872

C

Seeded From UniProt

complete

enables

GO:0017069

snRNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024872

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Lew, QJ et al. (2012) Identification of HEXIM1 as a positive regulator of p53. J. Biol. Chem. 287 36443-54 PubMed GONUTS page
  2. ↑ 2.0 2.1 Morchikh, M et al. (2017) HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Mol. Cell 67 387-399.e5 PubMed GONUTS page
  3. ↑ Czudnochowski, N et al. (2010) Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA. J. Mol. Biol. 395 28-41 PubMed GONUTS page
  4. ↑ Michels, AA et al. (2003) MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. Mol. Cell. Biol. 23 4859-69 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Yik, JH et al. (2003) Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Mol. Cell 12 971-82 PubMed GONUTS page
  6. ↑ 6.0 6.1 Ouchida, R et al. (2003) Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Genes Cells 8 95-107 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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