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HUMAN:GOLP3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GOLPH3 (synonyms: GPP34) | |
| Protein Name(s) | Golgi phosphoprotein 3
Coat protein GPP34 Mitochondrial DNA absence factor MIDAS | |
| External Links | ||
| UniProt | Q9H4A6 | |
| EMBL | AJ296152 AK075156 AL356292 AL356356 BC012123 BC033725 BC063586 AL133078 | |
| CCDS | CCDS3896.1 | |
| PIR | T42677 | |
| RefSeq | NP_071413.1 | |
| UniGene | Hs.408909 | |
| PDB | 3KN1 | |
| PDBsum | 3KN1 | |
| ProteinModelPortal | Q9H4A6 | |
| SMR | Q9H4A6 | |
| BioGrid | 122048 | |
| IntAct | Q9H4A6 | |
| MINT | MINT-5001986 | |
| STRING | 9606.ENSP00000265070 | |
| PhosphoSite | Q9H4A6 | |
| DMDM | 50400651 | |
| MaxQB | Q9H4A6 | |
| PaxDb | Q9H4A6 | |
| PRIDE | Q9H4A6 | |
| Ensembl | ENST00000265070 | |
| GeneID | 64083 | |
| KEGG | hsa:64083 | |
| UCSC | uc003jhp.1 | |
| CTD | 64083 | |
| GeneCards | GC05M032124 | |
| H-InvDB | HIX0032097 | |
| HGNC | HGNC:15452 | |
| HPA | HPA044564 | |
| MIM | 612207 | |
| neXtProt | NX_Q9H4A6 | |
| PharmGKB | PA28812 | |
| eggNOG | NOG79916 | |
| GeneTree | ENSGT00390000007153 | |
| HOGENOM | HOG000209848 | |
| HOVERGEN | HBG059607 | |
| InParanoid | Q9H4A6 | |
| KO | K15620 | |
| OMA | DYELAMR | |
| OrthoDB | EOG7ZKSBV | |
| PhylomeDB | Q9H4A6 | |
| TreeFam | TF314360 | |
| ChiTaRS | GOLPH3 | |
| EvolutionaryTrace | Q9H4A6 | |
| GenomeRNAi | 64083 | |
| NextBio | 65876 | |
| PRO | PR:Q9H4A6 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H4A6 | |
| CleanEx | HS_GOLPH3 | |
| ExpressionAtlas | Q9H4A6 | |
| Genevestigator | Q9H4A6 | |
| GO | GO:0005829 GO:0005768 GO:0031985 GO:0032580 GO:0005758 GO:0005739 GO:0005886 GO:0005802 GO:0019899 GO:0070273 GO:0060352 GO:0016477 GO:0008283 GO:0010467 GO:0009101 GO:0007030 GO:0043001 GO:0048194 GO:0030032 GO:0050901 GO:0050714 GO:0032008 GO:0045053 GO:0009306 GO:0010821 | |
| InterPro | IPR008628 | |
| PANTHER | PTHR12704 | |
| Pfam | PF05719 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051645 |
Golgi localization |
ECO:0000315 |
P |
Figure 3b: knockout of GOLPH3 resulted in decreased dispersion of Golgi bodies. |
complete | |||||
| GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
P |
Figure 7: siRNA knockout of GOLPH3 results in decreased survival after being subjected to DNA damage, indicating GOLPH3 participates in a pathway preventing apoptosis. |
complete | |||||
| GO:0000138 |
Golgi trans cisterna |
ECO:0000314 |
C |
Figure S2 shows the GOLPH3 colocalizes to the Golgi with trans-golgi markers |
complete | |||||
| GO:0043001 |
Golgi to plasma membrane protein transport |
ECO:0000315 |
P |
Figure 3B - siRNA KO of GOLPH3 resulted in impaired trafficking of VSVG-GFP from trans-golgi to PM |
complete | |||||
| GO:0090161 |
Golgi ribbon formation |
ECO:0000315 |
P |
Figure 3C - siRNA KO of GOLPH3 results in condensation of the normal golgi ribbon structure around the nucleus. |
complete | |||||
| GO:0090164 |
asymmetric Golgi ribbon formation |
ECO:0000315 |
P |
Figure 6- KO of GOLPH3 results in dilated cisternae of the golgi apparatus. It is asymmetrical dilation of the trans-golgi. |
complete | |||||
| GO:0005794 |
Golgi apparatus |
ECO:0000315 |
C |
Figure 7. Without a particular beta-hairpin motif, the protein fails to localize to the golgi correctly. |
complete | |||||
| GO:0005802 |
trans-Golgi network |
ECO:0000314 |
C |
Figure S2A shows the GOLPH3 colocalizes with trans-golgi markers |
complete | |||||
| GO:0005794 |
Golgi apparatus |
ECO:0000315 |
C |
Figure 7E. Without a particular beta-hairpin motif, the protein fails to localize to the golgi correctly. |
complete | |||||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090164 |
asymmetric Golgi ribbon formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090161 |
Golgi ribbon formation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043001 |
Golgi to plasma membrane protein transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060352 |
cell adhesion molecule production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050901 |
leukocyte tethering or rolling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050714 |
positive regulation of protein secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048194 |
Golgi vesicle budding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045053 |
protein retention in Golgi apparatus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043001 |
Golgi to plasma membrane protein transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032008 |
positive regulation of TOR signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031985 |
Golgi cisterna |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030032 |
lamellipodium assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019899 |
enzyme binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010821 |
regulation of mitochondrion organization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010467 |
gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009306 |
protein secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009101 |
glycoprotein biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048194 |
Golgi vesicle budding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043001 |
Golgi to plasma membrane protein transport |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031985 |
Golgi cisterna |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007030 |
Golgi organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005802 |
trans-Golgi network |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000294961 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9CRA5 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070273 |
phosphatidylinositol-4-phosphate binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008289 |
lipid binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005758 |
mitochondrial intermembrane space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032580 |
Golgi cisterna membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Farber-Katz, SE et al. (2014) DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell 156 413-27 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 Dippold, HC et al. (2009) GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell 139 337-51 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Schmitz, KR et al. (2008) Golgi localization of glycosyltransferases requires a Vps74p oligomer. Dev. Cell 14 523-34 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Ng, MM et al. (2013) GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Mol. Biol. Cell 24 796-808 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Ali, MF et al. (2012) Golgi phosphoprotein 3 determines cell binding properties under dynamic flow by controlling Golgi localization of core 2 N-acetylglucosaminyltransferase 1. J. Biol. Chem. 287 39564-77 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Scott, KL et al. (2009) GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature 459 1085-90 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Zhou, X et al. (2013) GOLPH3 regulates the migration and invasion of glioma cells though RhoA. Biochem. Biophys. Res. Commun. 433 338-44 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Nakashima-Kamimura, N et al. (2005) MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction. J. Cell. Sci. 118 5357-67 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
g
- GO:0010467 ! gene expression
- GO:0009101 ! glycoprotein biosynthetic process
- GO:0005794 ! Golgi apparatus
- GO:0032580 ! Golgi cisterna membrane
- GO:0031985 ! Golgi cisterna
- GO:0051645 ! Golgi localization
- GO:0007030 ! Golgi organization
- GO:0090161 ! Golgi ribbon formation
- GO:0043001 ! Golgi to plasma membrane protein transport
- GO:0000138 ! Golgi trans cisterna
- GO:0048194 ! Golgi vesicle budding
l
m
p
- GO:0070273 ! phosphatidylinositol-4-phosphate binding
- GO:0005886 ! plasma membrane
- GO:0050714 ! positive regulation of protein secretion
- GO:0032008 ! positive regulation of TOR signaling
- Primates
- GO:0045053 ! protein retention in Golgi apparatus
- GO:0009306 ! protein secretion
- GO:0015031 ! protein transport
r
