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HUMAN:GNAQ

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GNAQ (synonyms: GAQ)
Protein Name(s) Guanine nucleotide-binding protein G(q) subunit alpha

Guanine nucleotide-binding protein alpha-q

External Links
UniProt P50148
EMBL U40038
U43083
L76256
AF329284
AF011496
AF493896
AL160268
AL160278
AL355535
AL355535
AL160268
AL160278
AL160278
AL160268
AL355535
CH471089
BC057777
BC067850
BC069520
BC075096
BC075097
L40629
CCDS CCDS6658.1
PIR S59635
S71963
RefSeq NP_002063.2
UniGene Hs.269782
Hs.594695
ProteinModelPortal P50148
SMR P50148
BioGrid 109038
IntAct P50148
MINT MINT-262439
STRING 9606.ENSP00000286548
PhosphoSite P50148
DMDM 251757492
MaxQB P50148
PaxDb P50148
PRIDE P50148
DNASU 2776
Ensembl ENST00000286548
GeneID 2776
KEGG hsa:2776
UCSC uc004akw.3
CTD 2776
GeneCards GC09M080331
HGNC HGNC:4390
HPA CAB010036
HPA048886
MIM 163000
185300
600998
neXtProt NX_P50148
Orphanet 624
3205
PharmGKB PA174
eggNOG NOG322962
GeneTree ENSGT00760000118851
HOGENOM HOG000038729
HOVERGEN HBG063184
InParanoid P50148
KO K04634
OMA VESDNEX
OrthoDB EOG7ZWD1W
PhylomeDB P50148
TreeFam TF300673
Reactome REACT_18283
REACT_18405
REACT_19140
REACT_19193
REACT_20647
REACT_21384
SignaLink P50148
ChiTaRS GNAQ
GeneWiki GNAQ
GenomeRNAi 2776
NextBio 10922
PRO PR:P50148
Proteomes UP000005640
Bgee P50148
CleanEx HS_GNAQ
ExpressionAtlas P50148
Genevestigator P50148
GO GO:0005737
GO:0070062
GO:0005834
GO:0005765
GO:0031965
GO:0005886
GO:0031683
GO:0005525
GO:0005096
GO:0003924
GO:0046872
GO:0004871
GO:0031826
GO:0001508
GO:0007202
GO:0007189
GO:0007596
GO:0048066
GO:0042733
GO:0021884
GO:0007215
GO:0007507
GO:0042711
GO:0006469
GO:0016322
GO:0060158
GO:0030168
GO:0043547
GO:0009791
GO:0050821
GO:0035412
GO:0045634
GO:0001501
Gene3D 1.10.400.10
3.40.50.300
InterPro IPR000654
IPR001019
IPR011025
IPR027417
PANTHER PTHR10218
Pfam PF00503
PRINTS PR00318
PR00442
SMART SM00275
SUPFAM SSF47895
SSF52540

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007603

phototransduction, visible light

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q71RI7

P

occurs_in:(CL:0000652)

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q71RI7

C

part_of:(UBERON:0000966)

Seeded From UniProt

complete

part_of

GO:0001750

photoreceptor outer segment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5F3B5

C

part_of:(UBERON:0000966)

Seeded From UniProt

complete

involved_in

GO:0007213

G protein-coupled acetylcholine receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q71RI7

P

occurs_in:(CL:0000652)

Seeded From UniProt

complete

involved_in

GO:0009649

entrainment of circadian clock

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5F3B5

P

occurs_in:(CL:0000652)

Seeded From UniProt

complete

involved_in

GO:0009649

entrainment of circadian clock

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q71RI7

P

occurs_in:(CL:0000652)

Seeded From UniProt

complete

involved_in

GO:0007603

phototransduction, visible light

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5F3B5

P

occurs_in:(CL:0000652)

Seeded From UniProt

complete

involved_in

GO:0007213

G protein-coupled acetylcholine receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5F3B5

P

occurs_in:(CL:0000652)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0050821

protein stabilization

PMID:20399743[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060828

regulation of canonical Wnt signaling pathway

PMID:20399743[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

PMID:20399743[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005765

lysosomal membrane

PMID:17897319[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:15611106[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0031826

type 2A serotonin receptor binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000026458
RGD:620770

F

Seeded From UniProt

complete

enables

GO:0031683

G-protein beta/gamma-subunit complex binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95778
PANTHER:PTN000026392

F

Seeded From UniProt

complete

involved_in

GO:0007215

glutamate receptor signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95776
PANTHER:PTN000026458

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95776
PANTHER:PTN000026458

P

Seeded From UniProt

complete

involved_in

GO:0007188

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95768
PANTHER:PTN000026392
RGD:2717
dictyBase:DDB_G0276267

P

Seeded From UniProt

complete

part_of

GO:0005834

heterotrimeric G-protein complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001122
FB:FBgn0001123
MGI:MGI:3588268
PANTHER:PTN000026392
PomBase:SPAC23H3.13c
RGD:1304683
RGD:2716
SGD:S000001047
TAIR:locus:2005529
dictyBase:DDB_G0276267

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000026458
UniProtKB:P50148

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004435
MGI:MGI:3588268
MGI:MGI:95775
MGI:MGI:95778
PANTHER:PTN000026392
PomBase:SPBC24C6.06
RGD:2713
RGD:628732
RGD:727817
SGD:S000000822
SGD:S000001047
TAIR:locus:2005529
TAIR:locus:2034446
TAIR:locus:2046738
TAIR:locus:2116204
UniProtKB:P08754
UniProtKB:Q00743
WB:WBGene00001648
dictyBase:DDB_G0276267
dictyBase:DDB_G0283349

F

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95770
PANTHER:PTN000026392
RGD:2713
UniProtKB:P04695
UniProtKB:P30679
dictyBase:DDB_G0276267

F

Seeded From UniProt

complete

involved_in

GO:0001508

action potential

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95776
PANTHER:PTN000026458

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000654

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000654
InterPro:IPR001019

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011025

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000654
InterPro:IPR001019

P

Seeded From UniProt

complete

enables

GO:0019001

guanyl nucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001019

F

Seeded From UniProt

complete

enables

GO:0031683

G-protein beta/gamma-subunit complex binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001019

F

Seeded From UniProt

complete

involved_in

GO:0007596

blood coagulation

PMID:9238049[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007202

activation of phospholipase C activity

PMID:8825633[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9175863[10]
PMID:10633085[11]
Reactome:R-HSA-8982026
Reactome:R-HSA-8982025
Reactome:R-HSA-8982017
Reactome:R-HSA-8964340
Reactome:R-HSA-8964284
Reactome:R-HSA-8964280
Reactome:R-HSA-750993
Reactome:R-HSA-749452
Reactome:R-HSA-749448
Reactome:R-HSA-428941
Reactome:R-HSA-428752
Reactome:R-HSA-428750
Reactome:R-HSA-428749
Reactome:R-HSA-418582
Reactome:R-HSA-418576
Reactome:R-HSA-416516
Reactome:R-HSA-416358
Reactome:R-HSA-400586
Reactome:R-HSA-397835
Reactome:R-HSA-396996
Reactome:R-HSA-379048
Reactome:R-HSA-114688
Reactome:R-HSA-114558

ECO:0000304

author statement supported by traceable reference used in manual assertion

























C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:9175863[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:9238049[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030168

platelet activation

Reactome:R-HSA-76002

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0182

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Salmanian, S et al. (2010) Regulation of GSK-3beta and beta-Catenin by Galphaq in HEK293T cells. Biochem. Biophys. Res. Commun. 395 577-82 PubMed GONUTS page
  5. ↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
  6. ↑ Barnes, WG et al. (2005) beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. 280 8041-50 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 Gabbeta, J et al. (1997) Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. Proc. Natl. Acad. Sci. U.S.A. 94 8750-5 PubMed GONUTS page
  9. ↑ Dong, Q et al. (1995) Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene. Genomics 30 470-75 PubMed GONUTS page
  10. ↑ 10.0 10.1 Wise, A et al. (1997) Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. FEBS Lett. 407 257-60 PubMed GONUTS page
  11. ↑ Miotti, S et al. (2000) Interaction of folate receptor with signaling molecules lyn and G(alpha)(i-3) in detergent-resistant complexes from the ovary carcinoma cell line IGROV1. J. Cell. Sci. 113 Pt 2 349-57 PubMed GONUTS page
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