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HUMAN:GAB1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | GAB1 | |
Protein Name(s) | GRB2-associated-binding protein 1
GRB2-associated binder 1 Growth factor receptor bound protein 2-associated protein 1 | |
External Links | ||
UniProt | Q13480 | |
EMBL | U43885 DQ021880 AK289767 AC097658 AC104685 CH471056 BC064848 | |
CCDS | CCDS3759.1 CCDS3760.1 | |
PIR | S68442 | |
RefSeq | NP_002030.2 NP_997006.1 | |
UniGene | Hs.618456 Hs.80720 | |
ProteinModelPortal | Q13480 | |
SMR | Q13480 | |
BioGrid | 108824 | |
IntAct | Q13480 | |
MINT | MINT-140909 | |
STRING | 9606.ENSP00000262995 | |
PhosphoSite | Q13480 | |
DMDM | 90180201 | |
MaxQB | Q13480 | |
PaxDb | Q13480 | |
PRIDE | Q13480 | |
DNASU | 2549 | |
Ensembl | ENST00000262994 ENST00000262995 | |
GeneID | 2549 | |
KEGG | hsa:2549 | |
UCSC | uc003ijd.3 uc003ije.3 | |
CTD | 2549 | |
GeneCards | GC04P144257 | |
H-InvDB | HIX0004529 | |
HGNC | HGNC:4066 | |
MIM | 604439 | |
neXtProt | NX_Q13480 | |
PharmGKB | PA28477 | |
eggNOG | NOG80382 | |
GeneTree | ENSGT00510000046662 | |
HOGENOM | HOG000236270 | |
HOVERGEN | HBG051685 | |
InParanoid | Q13480 | |
KO | K09593 | |
OMA | QIPRTFP | |
OrthoDB | EOG7T4MJJ | |
PhylomeDB | Q13480 | |
TreeFam | TF329487 | |
Reactome | REACT_115852 REACT_116008 REACT_121398 REACT_12578 REACT_147727 REACT_21270 REACT_75829 REACT_976 | |
SignaLink | Q13480 | |
ChiTaRS | GAB1 | |
GeneWiki | GAB1 | |
GenomeRNAi | 2549 | |
NextBio | 10055 | |
PRO | PR:Q13480 | |
Proteomes | UP000005640 | |
Bgee | Q13480 | |
CleanEx | HS_GAB1 | |
ExpressionAtlas | Q13480 | |
Genevestigator | Q13480 | |
GO | GO:0005829 GO:0005070 GO:0004871 GO:0007257 GO:0008283 GO:0007173 GO:0008544 GO:0038095 GO:0008543 GO:0007507 GO:0045087 GO:0008286 GO:0070102 GO:0060711 GO:0048011 GO:0048015 GO:0048008 GO:0030334 GO:0006979 | |
Gene3D | 2.30.29.30 | |
InterPro | IPR001849 IPR011993 | |
Pfam | PF00169 | |
SMART | SM00233 | |
PROSITE | PS50003 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0038089 |
positive regulation of cell migration by vascular endothelial growth factor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_in:(CL:0002544) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031532 |
actin cytoskeleton reorganization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:2000008) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:2000008) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090668 |
endothelial cell chemotaxis to vascular endothelial growth factor |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
results_in_movement_of:(CL:2000008) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0038084 |
vascular endothelial growth factor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:2000008) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000071) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035728 |
response to hepatocyte growth factor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:A0A0G2JZD5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008286 |
insulin receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
PMID:8596638[3] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | |
enables |
GO:0005070 |
SH3/SH2 adaptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051897 |
positive regulation of protein kinase B signaling |
Reactome:R-HSA-2316434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0038128 |
ERBB2 signaling pathway |
Reactome:R-HSA-1227986 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
GO:2000147 |
positive regulation of cell motility |
ECO:0000314 |
P |
Figure 2. Gab1 constitutively enhances migration and stimulates adhesion of 32D/Met cells. A: The migration of 32D/Met cells (open bars), 32D/Met/Gab1clone 1W5 (black bars), and 32D/Met/Gab1 clone 1W3 (gray bars) was measured using modified Boyden chambers. NK1 concentrations are indicated on the X-axis. Results are expressed as number of migrating cells/ml of medium in the bottom chamber and are representative of three or more experiments. |
complete | |||||
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
Reactome:R-HSA-9027276 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007411 |
axon guidance |
Reactome:R-HSA-422475 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-9027281 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Laramée, M et al. (2007) The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. J. Biol. Chem. 282 7758-69 PubMed GONUTS page
- ↑ Kumarswamy, R et al. (2014) Vascular importance of the miR-212/132 cluster. Eur. Heart J. 35 3224-31 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Holgado-Madruga, M et al. (1996) A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379 560-4 PubMed GONUTS page
- ↑ Felici, A et al. (2010) Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells. J. Cell. Biochem. 111 310-21 PubMed GONUTS page
e
o
p
- GO:2000147 ! positive regulation of cell motility
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0045766 ! positive regulation of angiogenesis
- GO:0038089 ! positive regulation of cell migration by vascular endothelial growth factor signaling pathway
- Primates