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HUMAN:GAB1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) GAB1
Protein Name(s) GRB2-associated-binding protein 1

GRB2-associated binder 1 Growth factor receptor bound protein 2-associated protein 1

External Links
UniProt Q13480
EMBL U43885
DQ021880
AK289767
AC097658
AC104685
CH471056
BC064848
CCDS CCDS3759.1
CCDS3760.1
PIR S68442
RefSeq NP_002030.2
NP_997006.1
UniGene Hs.618456
Hs.80720
ProteinModelPortal Q13480
SMR Q13480
BioGrid 108824
IntAct Q13480
MINT MINT-140909
STRING 9606.ENSP00000262995
PhosphoSite Q13480
DMDM 90180201
MaxQB Q13480
PaxDb Q13480
PRIDE Q13480
DNASU 2549
Ensembl ENST00000262994
ENST00000262995
GeneID 2549
KEGG hsa:2549
UCSC uc003ijd.3
uc003ije.3
CTD 2549
GeneCards GC04P144257
H-InvDB HIX0004529
HGNC HGNC:4066
MIM 604439
neXtProt NX_Q13480
PharmGKB PA28477
eggNOG NOG80382
GeneTree ENSGT00510000046662
HOGENOM HOG000236270
HOVERGEN HBG051685
InParanoid Q13480
KO K09593
OMA QIPRTFP
OrthoDB EOG7T4MJJ
PhylomeDB Q13480
TreeFam TF329487
Reactome REACT_115852
REACT_116008
REACT_121398
REACT_12578
REACT_147727
REACT_21270
REACT_75829
REACT_976
SignaLink Q13480
ChiTaRS GAB1
GeneWiki GAB1
GenomeRNAi 2549
NextBio 10055
PRO PR:Q13480
Proteomes UP000005640
Bgee Q13480
CleanEx HS_GAB1
ExpressionAtlas Q13480
Genevestigator Q13480
GO GO:0005829
GO:0005070
GO:0004871
GO:0007257
GO:0008283
GO:0007173
GO:0008544
GO:0038095
GO:0008543
GO:0007507
GO:0045087
GO:0008286
GO:0070102
GO:0060711
GO:0048011
GO:0048015
GO:0048008
GO:0030334
GO:0006979
Gene3D 2.30.29.30
InterPro IPR001849
IPR011993
Pfam PF00169
SMART SM00233
PROSITE PS50003

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0038089

positive regulation of cell migration by vascular endothelial growth factor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QYY0

P

occurs_in:(CL:0002544)

Seeded From UniProt

complete

involved_in

GO:0031532

actin cytoskeleton reorganization

PMID:17178724[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:2000008)

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

PMID:17178724[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:2000008)

Seeded From UniProt

complete

involved_in

GO:0090668

endothelial cell chemotaxis to vascular endothelial growth factor

PMID:17178724[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_movement_of:(CL:2000008)

Seeded From UniProt

complete

involved_in

GO:0038084

vascular endothelial growth factor signaling pathway

PMID:17178724[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:2000008)

Seeded From UniProt

complete

involved_in

GO:0045766

positive regulation of angiogenesis

PMID:25217442[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000071)

Seeded From UniProt

complete

involved_in

GO:0035728

response to hepatocyte growth factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A0A0G2JZD5
ensembl:ENSRNOP00000071006

P

Seeded From UniProt

complete

involved_in

GO:0008286

insulin receptor signaling pathway

PMID:8596638[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007173

epidermal growth factor receptor signaling pathway

PMID:8596638[3]
Reactome:R-HSA-177929

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:8596638[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051897

positive regulation of protein kinase B signaling

Reactome:R-HSA-2316434

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038128

ERBB2 signaling pathway

Reactome:R-HSA-1227986

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

GO:2000147

positive regulation of cell motility

PMID:20506405[4]

ECO:0000314

P

Figure 2. Gab1 constitutively enhances migration and stimulates adhesion of 32D/Met cells. A: The migration of 32D/Met cells (open bars), 32D/Met/Gab1clone 1W5 (black bars), and 32D/Met/Gab1 clone 1W3 (gray bars) was measured using modified Boyden chambers. NK1 concentrations are indicated on the X-axis. Results are expressed as number of migrating cells/ml of medium in the bottom chamber and are representative of three or more experiments.

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

Reactome:R-HSA-9027276

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

Reactome:R-HSA-422475

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-9027281
Reactome:R-HSA-9027275
Reactome:R-HSA-9027273
Reactome:R-HSA-9021627
Reactome:R-HSA-8875661
Reactome:R-HSA-8875659
Reactome:R-HSA-8875591
Reactome:R-HSA-8875576
Reactome:R-HSA-8875568
Reactome:R-HSA-8875558
Reactome:R-HSA-8875540
Reactome:R-HSA-8865994
Reactome:R-HSA-8855508
Reactome:R-HSA-8854905
Reactome:R-HSA-8854897
Reactome:R-HSA-8853774
Reactome:R-HSA-8853323
Reactome:R-HSA-8853316
Reactome:R-HSA-8853308
Reactome:R-HSA-8852019
Reactome:R-HSA-8851954
Reactome:R-HSA-8851933
Reactome:R-HSA-8851919
Reactome:R-HSA-8851908
Reactome:R-HSA-5655323
Reactome:R-HSA-5655320
Reactome:R-HSA-5655315
Reactome:R-HSA-5655290
Reactome:R-HSA-5655289
Reactome:R-HSA-5655285
Reactome:R-HSA-5655263
Reactome:R-HSA-5655252
Reactome:R-HSA-5655248
Reactome:R-HSA-5655245
Reactome:R-HSA-5655240
Reactome:R-HSA-5655235
Reactome:R-HSA-5654717
Reactome:R-HSA-5654714
Reactome:R-HSA-5654709
Reactome:R-HSA-5654705
Reactome:R-HSA-5654701
Reactome:R-HSA-5654697
Reactome:R-HSA-5654692
Reactome:R-HSA-5654690
Reactome:R-HSA-5654669
Reactome:R-HSA-5654667
Reactome:R-HSA-5654662
Reactome:R-HSA-5654659
Reactome:R-HSA-5654643
Reactome:R-HSA-5654641
Reactome:R-HSA-5654640
Reactome:R-HSA-5654637
Reactome:R-HSA-5654622
Reactome:R-HSA-5654620
Reactome:R-HSA-5654614
Reactome:R-HSA-5654612
Reactome:R-HSA-5654596
Reactome:R-HSA-5654594
Reactome:R-HSA-5654592
Reactome:R-HSA-5654591
Reactome:R-HSA-5637801
Reactome:R-HSA-5637765
Reactome:R-HSA-5637764
Reactome:R-HSA-2400009
Reactome:R-HSA-2316434
Reactome:R-HSA-179467
Reactome:R-HSA-177944
Reactome:R-HSA-177941
Reactome:R-HSA-177939
Reactome:R-HSA-177935
Reactome:R-HSA-177931
Reactome:R-HSA-177930
Reactome:R-HSA-177927
Reactome:R-HSA-177926
Reactome:R-HSA-177924
Reactome:R-HSA-177923
Reactome:R-HSA-177920
Reactome:R-HSA-1306965
Reactome:R-HSA-1306963
Reactome:R-HSA-1306957
Reactome:R-HSA-1226016
Reactome:R-HSA-1226014
Reactome:R-HSA-1226012
Reactome:R-HSA-109699

ECO:0000304

author statement supported by traceable reference used in manual assertion




















































































C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Laramée, M et al. (2007) The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation. J. Biol. Chem. 282 7758-69 PubMed GONUTS page
  2. Kumarswamy, R et al. (2014) Vascular importance of the miR-212/132 cluster. Eur. Heart J. 35 3224-31 PubMed GONUTS page
  3. 3.0 3.1 3.2 Holgado-Madruga, M et al. (1996) A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Nature 379 560-4 PubMed GONUTS page
  4. Felici, A et al. (2010) Gab1 mediates hepatocyte growth factor-stimulated mitogenicity and morphogenesis in multipotent myeloid cells. J. Cell. Biochem. 111 310-21 PubMed GONUTS page