HUMAN:G6PD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	G6PD
Protein Name(s)	Glucose-6-phosphate 1-dehydrogenase G6PD
External Links
UniProt	P11413
EMBL	X03674 M65234 M26749 M26750 M65225 M65226 M65227 M65228 M65229 M65230 M65231 M65233 M65232 M21248 M19866 X55448 L44140 AF277315 CH471172 CH471172 BC000337 M27940 S58359 X53815 S64462 AY158096 AY158097 AY158098 AY158099 AY158100 AY158101 AY158102 AY158103 AY158104 AY158105 AY158106 AY158107 AY158108 AY158109 AY158110 AY158111 AY158112 AY158113 AY158114 AY158115 AY158116 AY158117 AY158118 AY158119 AY158120 AY158121 AY158122 AY158123 AY158124 AY158125 AY158126 AY158127 AY158128 AY158129 AY158130 AY158131 AY158132 AY158133 AY158134 AY158135 AY158136 AY158137 AY158138 AY158139 AY158140 AY158141 AY158142 M12996 M23423
CCDS	CCDS14756.2 CCDS44023.1
PIR	A40309
RefSeq	NP_000393.4 NP_001035810.1
UniGene	Hs.461047 Hs.684904
PDB	1QKI 2BH9 2BHL
PDBsum	1QKI 2BH9 2BHL
ProteinModelPortal	P11413
SMR	P11413
BioGrid	108814
IntAct	P11413
MINT	MINT-4716941
STRING	9606.ENSP00000377192
BindingDB	P11413
ChEMBL	CHEMBL5347
PhosphoSite	P11413
DMDM	116242483
REPRODUCTION-2DPAGE	IPI00289800
SWISS-2DPAGE	P11413
MaxQB	P11413
PaxDb	P11413
PRIDE	P11413
DNASU	2539
Ensembl	ENST00000369620 ENST00000393562 ENST00000393564 ENST00000621232
GeneID	2539
KEGG	hsa:2539
UCSC	uc004flx.1 uc004fly.1
CTD	2539
GeneCards	GC0XM153759
HGNC	HGNC:4057
HPA	HPA000247 HPA000834
MIM	300908 305900
neXtProt	NX_P11413
Orphanet	362
PharmGKB	PA28469
eggNOG	COG0364
GeneTree	ENSGT00530000063435
HOVERGEN	HBG000856
InParanoid	P11413
KO	K00036
OMA	TIFEPIW
PhylomeDB	P11413
TreeFam	TF300584
BioCyc	MetaCyc:HS08467-MONOMER
Reactome	REACT_1859
SABIO-RK	P11413
UniPathway	UPA00115
ChiTaRS	G6PD
EvolutionaryTrace	P11413
GeneWiki	Glucose-6-phosphate_dehydrogenase
GenomeRNAi	2539
NextBio	10021
PRO	PR:P11413
Proteomes	UP000005640
Bgee	P11413
CleanEx	HS_G6PD
ExpressionAtlas	P11413
Genevestigator	P11413
GO	GO:0005737 GO:0009898 GO:0005829 GO:0070062 GO:0016020 GO:0005634 GO:0005536 GO:0004345 GO:0050661 GO:0042803 GO:0005975 GO:0034599 GO:0006695 GO:0001816 GO:0043249 GO:0051156 GO:0006749 GO:0006629 GO:0006739 GO:0006740 GO:0010734 GO:0055114 GO:0019322 GO:0006098 GO:0009051 GO:0043523 GO:0045471 GO:0032094 GO:0014070 GO:0046390 GO:0044281 GO:0021762
Gene3D	3.40.50.720
HAMAP	MF_00966
InterPro	IPR001282 IPR019796 IPR022675 IPR022674 IPR016040
PANTHER	PTHR23429
Pfam	PF02781 PF00479
PIRSF	PIRSF000110
PRINTS	PR00079
TIGRFAMs	TIGR00871
PROSITE	PS00069

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0021762	substantia nigra development	PMID:22926577^[4]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000054	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	PMID:2420826^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	PMID:5643703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:15858258^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046390	ribose phosphate biosynthetic process	PMID:2420826^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043249	erythrocyte maturation	PMID:5643703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:15858258^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11413	F		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:17516514^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019322	pentose biosynthetic process	PMID:5643703^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010734	negative regulation of protein glutathionylation	PMID:17516514^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:743300^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009051	pentose-phosphate shunt, oxidative branch	PMID:2420826^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	PMID:17516514^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	PMID:2420826^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006740	NADPH regeneration	PMID:17516514^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006695	cholesterol biosynthetic process	PMID:12027950^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	PMID:2297768^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:743300^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:5643703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:15858258^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:5643703^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:743300^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:2420826^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	PMID:15858258^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006739	NADP metabolic process	PMID:15858258^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	PMID:15858258^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11413	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:24769394^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11413	F		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	F		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	C		Seeded From UniProt	complete
involved_in	GO:0032094	response to food	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:0010041	response to iron(III) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:0009051	pentose-phosphate shunt, oxidative branch	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	C		Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	F		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05370 ensembl:ENSRNOP00000075297	F		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019796 InterPro:IPR022674 InterPro:IPR022675	F		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001282 InterPro:IPR019796 InterPro:IPR022674 InterPro:IPR022675	P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022674 InterPro:IPR022675	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001282 InterPro:IPR019796 InterPro:IPR022674 InterPro:IPR022675	P		Seeded From UniProt	complete
enables	GO:0004345	glucose-6-phosphate dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.49	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:17361089^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	Reactome:R-HSA-71336	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-70377	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006098	pentose-phosphate shunt	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00115	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Roth, EF Jr et al. (1986) Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum. J. Clin. Invest. 77 1129-35 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Beutler, E et al. (1968) Biochemical variants of glucose-6-phosphate dehydrogenase giving rise to congenital nonspherocytic hemolytic disease. Blood 31 131-50 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Kotaka, M et al. (2005) Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase. Acta Crystallogr. D Biol. Crystallogr. 61 495-504 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ayene, IS et al. (2008) Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication. J. Cell. Biochem. 103 123-35 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Benatti, U et al. (1978) Glucose 6-phosphate dehydrogenase activity in membranes of erythrocytes from normal individuals and subjects with Mediterranean G6PD deficiency. Biochem. Biophys. Res. Commun. 85 1318-24 PubMed GONUTS page
↑ Batetta, B et al. (2002) Cell growth and cholesterol metabolism in human glucose-6-phosphate dehydrogenase deficient lymphomononuclear cells. Cell Prolif. 35 143-54 PubMed GONUTS page
↑ Thomas, M et al. (1990) Sex steroid hormone modulation of NADPH pathways in MCF-7 cells. Cancer Res. 50 1195-200 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
↑ Wang, YP et al. (2014) Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 33 1304-20 PubMed GONUTS page
↑ Sanna, F et al. (2007) Production of inflammatory molecules in peripheral blood mononuclear cells from severely glucose-6-phosphate dehydrogenase-deficient subjects. J. Vasc. Res. 44 253-63 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-2] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:22926577-4] Chen, S et al. (2012) Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Neurochem. Res. 37 2805-13 PubMed GONUTS page

[PMID:2420826-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Roth, EF Jr et al. (1986) Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum. J. Clin. Invest. 77 1129-35 PubMed GONUTS page

[PMID:5643703-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Beutler, E et al. (1968) Biochemical variants of glucose-6-phosphate dehydrogenase giving rise to congenital nonspherocytic hemolytic disease. Blood 31 131-50 PubMed GONUTS page

[PMID:15858258-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Kotaka, M et al. (2005) Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase. Acta Crystallogr. D Biol. Crystallogr. 61 495-504 PubMed GONUTS page

[PMID:17516514-8] 8.0 ^8.1 ^8.2 ^8.3 Ayene, IS et al. (2008) Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication. J. Cell. Biochem. 103 123-35 PubMed GONUTS page

[PMID:743300-9] 9.0 ^9.1 ^9.2 Benatti, U et al. (1978) Glucose 6-phosphate dehydrogenase activity in membranes of erythrocytes from normal individuals and subjects with Mediterranean G6PD deficiency. Biochem. Biophys. Res. Commun. 85 1318-24 PubMed GONUTS page

[PMID:12027950-10] Batetta, B et al. (2002) Cell growth and cholesterol metabolism in human glucose-6-phosphate dehydrogenase deficient lymphomononuclear cells. Cell Prolif. 35 143-54 PubMed GONUTS page

[PMID:2297768-11] Thomas, M et al. (1990) Sex steroid hormone modulation of NADPH pathways in MCF-7 cells. Cancer Res. 50 1195-200 PubMed GONUTS page

[PMID:25416956-12] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:24769394-13] Wang, YP et al. (2014) Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 33 1304-20 PubMed GONUTS page

[PMID:17361089-14] Sanna, F et al. (2007) Production of inflammatory molecules in peripheral blood mononuclear cells from severely glucose-6-phosphate dehydrogenase-deficient subjects. J. Vasc. Res. 44 253-63 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

HUMAN:G6PD

Contents

Annotations

Notes

References

c

d

e

g

h

i

l

m

n

o

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools