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HUMAN:FUBP2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KHSRP (synonyms: FUBP2) | |
| Protein Name(s) | Far upstream element-binding protein 2
FUSE-binding protein 2 KH type-splicing regulatory protein KSRP p75 | |
| External Links | ||
| UniProt | Q92945 | |
| EMBL | U94832 AC011491 AC011539 BC085004 AF093747 AF093745 AF093748 U69126 AB209662 | |
| CCDS | CCDS45936.1 | |
| RefSeq | NP_003676.2 | |
| UniGene | Hs.727344 | |
| PDB | 2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T | |
| PDBsum | 2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T | |
| ProteinModelPortal | Q92945 | |
| SMR | Q92945 | |
| BioGrid | 114139 | |
| DIP | DIP-48484N | |
| IntAct | Q92945 | |
| MINT | MINT-2813544 | |
| STRING | 9606.ENSP00000381216 | |
| ChEMBL | CHEMBL1795105 | |
| iPTMnet | Q92945 | |
| PhosphoSitePlus | Q92945 | |
| SwissPalm | Q92945 | |
| BioMuta | KHSRP | |
| DMDM | 313104306 | |
| REPRODUCTION-2DPAGE | Q92945 | |
| EPD | Q92945 | |
| MaxQB | Q92945 | |
| PaxDb | Q92945 | |
| PeptideAtlas | Q92945 | |
| PRIDE | Q92945 | |
| Ensembl | ENST00000398148 | |
| GeneID | 8570 | |
| KEGG | hsa:8570 | |
| UCSC | uc002mer.5 | |
| CTD | 8570 | |
| DisGeNET | 8570 | |
| GeneCards | KHSRP MIR3940 | |
| H-InvDB | HIX0040083 | |
| HGNC | HGNC:6316 | |
| HPA | HPA034739 HPA056518 | |
| MIM | 603445 | |
| neXtProt | NX_Q92945 | |
| OpenTargets | ENSG00000088247 | |
| PharmGKB | PA30097 | |
| eggNOG | KOG1676 ENOG410XZYE | |
| GeneTree | ENSGT00730000110664 | |
| HOGENOM | HOG000231552 | |
| HOVERGEN | HBG000625 | |
| InParanoid | Q92945 | |
| KO | K13210 | |
| PhylomeDB | Q92945 | |
| TreeFam | TF313654 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-380994 R-HSA-380994] [www.reactome.org/content/detail/R-HSA-450604 R-HSA-450604] | |
| SIGNOR | Q92945 | |
| ChiTaRS | KHSRP | |
| EvolutionaryTrace | Q92945 | |
| GeneWiki | KHSRP | |
| GenomeRNAi | 8570 | |
| PMAP-CutDB | Q92945 | |
| PRO | PR:Q92945 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000088247 | |
| CleanEx | HS_KHSRP | |
| ExpressionAtlas | Q92945 | |
| Genevisible | Q92945 | |
| GO | GO:0010494 GO:0005829 GO:0016020 GO:0005654 GO:0003677 GO:0035925 GO:0003723 GO:0061158 GO:0071345 GO:0006402 GO:0006397 GO:0051028 GO:0045019 GO:0061014 GO:2000628 GO:0043488 GO:0006355 GO:0008380 GO:0000375 GO:0006351 | |
| Gene3D | 3.30.1370.10 | |
| InterPro | IPR015096 IPR004087 IPR004088 | |
| Pfam | PF09005 PF00013 | |
| SMART | SM00322 | |
| SUPFAM | SSF54791 | |
| PROSITE | PS50084 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0010989 |
negative regulation of low-density lipoprotein particle clearance |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
RNAcentral:URS00004176D4_9606 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0035925 |
mRNA 3'-UTR AU-rich region binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061158 |
3'-UTR-mediated mRNA destabilization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061014 |
positive regulation of mRNA catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0008284 |
positive regulation of cell proliferation |
ECO:0000315 |
P |
Organism: Homo sapiens. Paper’s Protein Name: K homology splicing regulatory protein (KSRP). UniProt’s Protein Name: Far upstream element-binding protein 2 OR ALTERNATIVELY KH type-splicing regulatory protein. Notes: Figures 2C-D are primarily used, but Figures 2A-B help to understand the resuls. This is because Figures 2A-B show that “Transfection of H2122 and H157 with two different KSRP specific siRNAs resulted in a significant reduction of KSRP expression.” Thus, when Figures 2C-D show that the “knockdown conditions” created by these siRNAs lead to decreased cellular proliferation over time, it is clear that KSRP is linked to cellular proliferation. No UniProt term appears to be specific to the non-small cell lung cancer cell line. |
complete | |||||
|
involved_in |
GO:0043488 |
regulation of mRNA stability |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045019 |
negative regulation of nitric oxide biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0030335 |
positive regulation of cell migration |
ECO:0000315 |
P |
Organism: Homo sapiens Paper’s Protein Name: K homology splicing regulatory protein (KSRP). UniProt’s Protein Name: Far upstream element-binding protein 2 OR ALTERNATIVELY KH type-splicing regulatory protein. Notes: Figure 3E is used. According to the paper, “the stable knockdown of KSRP resulted in reduced cell migration, when compared to H2122 clones stably expressing control shRNAs.” In other words, decreased levels of KSRP are linked to decreased levels of cellular migration. No UniProt term appears to be specific to the non-small cell lung cancer cell line. |
complete | |||||
|
colocalizes_with |
GO:0000178 |
exosome (RNase complex) |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0061158 |
3'-UTR-mediated mRNA destabilization |
ECO:0000315 |
P |
Paper’s Protein Name: K homology splicing regulatory protein (KSRP). UniProt’s Protein Name: Far upstream element-binding protein 2 OR ALTERNATIVELY KH type-splicing regulatory protein. Organism: Homo sapiens. Notes: Figure 6E is used. Figure 4 had already demonstrated that KSRP downregulates the Spry4 protein, and Figure 5D had already demonstrated that KSRP binds to the 3’-UTR mRNA of the Spry4 gene. In the paper, it is claimed that “if the effects of KSRP on Spry4 3’UTR were specific; then upon KSRP knockdown, the KSRP-mediated mRNA repression should be relaxed, as detected by an increase in luciferase activities. Indeed, knockdown of KSRP increased the luciferase activities of Luc-Spry4 UTR, but not the luciferase activities of Luc-Spry4 UTR-F1.” The chart in Figure 6E does indeed show that luciferase activities approximately double when KSRP is mutated. Thus, KSRP destabilizes the mRNA of Spry4 by binding to the 3’-UTR region. |
complete | |||||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010586 |
miRNA metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000628 |
regulation of miRNA metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3U0V1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3U0V1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006402 |
mRNA catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3U0V1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003729 |
mRNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3U0V1 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000375 |
RNA splicing, via transesterification reactions |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043488 |
regulation of mRNA stability |
Reactome:R-HSA-450604 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-450620 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-450620 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051028 |
mRNA transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008380 |
RNA splicing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006397 |
mRNA processing |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Jiang, H et al. (2015) microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator. Atherosclerosis 243 523-32 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Linker, K et al. (2005) Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res. 33 4813-27 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Bikkavilli, RK et al. (2017) KSRP promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer. J. Biol. Chem. PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Connerty, P et al. (2016) The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells. Biochim. Biophys. Acta 1859 1299-305 PubMed GONUTS page
- ↑ Min, H et al. (1997) A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. Genes Dev. 11 1023-36 PubMed GONUTS page
- ↑ 9.0 9.1 Chou, MY et al. (2000) Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol. Cell 5 949-57 PubMed GONUTS page
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