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HUMAN:FRK

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FRK (synonyms: PTK5, RAK)
Protein Name(s) Tyrosine-protein kinase FRK

FYN-related kinase Nuclear tyrosine protein kinase RAK Protein-tyrosine kinase 5

External Links
UniProt P42685
EMBL U22322
U00803
AK302264
AL021451
AL121963
AL357141
AL357141
AL121963
CH471051
BC012916
CCDS CCDS5103.1
PIR I38396
RefSeq NP_002022.1
XP_005266937.1
XP_005266938.1
XP_005266939.1
UniGene Hs.89426
ProteinModelPortal P42685
SMR P42685
BioGrid 108726
IntAct P42685
MINT MINT-3015573
STRING 9606.ENSP00000357615
BindingDB P42685
ChEMBL CHEMBL4223
DrugBank DB08896
GuidetoPHARMACOLOGY 2025
PhosphoSite P42685
DMDM 1169745
MaxQB P42685
PaxDb P42685
PRIDE P42685
DNASU 2444
Ensembl ENST00000606080
GeneID 2444
KEGG hsa:2444
UCSC uc003pwi.1
CTD 2444
GeneCards GC06M116308
HGNC HGNC:3955
HPA CAB025217
MIM 606573
neXtProt NX_P42685
PharmGKB PA28373
eggNOG COG0515
GeneTree ENSGT00760000118938
HOGENOM HOG000233858
HOVERGEN HBG008761
InParanoid P42685
KO K08892
OMA KNLRHPK
OrthoDB EOG7GTT2V
PhylomeDB P42685
TreeFam TF351634
BRENDA 2.7.10.2
SignaLink P42685
ChiTaRS FRK
GeneWiki Fyn-related_kinase
GenomeRNAi 2444
NextBio 35476135
PRO PR:P42685
Proteomes UP000005640
Bgee P42685
CleanEx HS_FRK
Genevestigator P42685
GO GO:0005737
GO:0070062
GO:0005622
GO:0005634
GO:0005886
GO:0005524
GO:0004715
GO:0030154
GO:0008285
GO:0018108
GO:0006468
Gene3D 3.30.505.10
InterPro IPR011009
IPR000719
IPR017441
IPR001245
IPR000980
IPR001452
IPR008266
IPR020635
Pfam PF07714
PF00017
PF00018
PRINTS PR00401
PR00452
PR00109
SMART SM00252
SM00326
SM00219
SUPFAM SSF50044
SSF55550
SSF56112
PROSITE PS00107
PS50011
PS00109
PS50001
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

PMID:12837246[1]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_transcription_of:(ENSEMBL:ENSG00000164362)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0038083

peptidyl-tyrosine autophosphorylation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
UniProtKB:Q9H3Y6
WB:WBGene00005077

P

Seeded From UniProt

complete

part_of

GO:0031234

extrinsic component of cytoplasmic side of plasma membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
UniProtKB:P08631

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
RGD:621423

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002521528
UniProtKB:P07948

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262733
PANTHER:PTN002521528
RGD:2641
RGD:620795
RGD:621017
UniProtKB:P12931

F

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95527
PANTHER:PTN002521528
UniProtKB:P09769
UniProtKB:P51451
UniProtKB:Q13882
WB:WBGene00005077

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:19345329[5]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62662
ensembl:ENSRNOP00000000653

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62662
ensembl:ENSRNOP00000000653

C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62662
ensembl:ENSRNOP00000000653

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR020635

P

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.2

F

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:7664264[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:7696183[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:7696183[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005622

intracellular

PMID:7510261[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

PMID:7510261[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035580

specific granule lumen

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0035578

azurophil granule lumen

Reactome:R-HSA-6798751

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8847977
Reactome:R-HSA-8847968

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798751
Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Lin, SY & Elledge, SJ (2003) Multiple tumor suppressor pathways negatively regulate telomerase. Cell 113 881-9 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Yim, EK et al. (2009) Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell 15 304-14 PubMed GONUTS page
  6. ↑ Craven, RJ et al. (1995) The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. Cancer Res. 55 3969-72 PubMed GONUTS page
  7. ↑ 7.0 7.1 Cance, WG et al. (1994) Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. Cell Growth Differ. 5 1347-55 PubMed GONUTS page
  8. ↑ 8.0 8.1 Lee, J et al. (1994) Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. Gene 138 247-51 PubMed GONUTS page
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