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PMID:7664264

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Citation

Craven, RJ, Cance, WG and Liu, ET (1995) The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. Cancer Res. 55:3969-72

Abstract

Rak is a nuclear tyrosine kinase containing Src homology 2 and 3 domains at its NH2 terminus. We report here that the retinoblastoma tumor susceptibility gene product pRb associates with Rak in vivo and in vitro. Rak binds in the A/B pocket region of pRb, a region that is frequently mutated in human cancer, during the G1 and S phases of the cell cycle. Furthermore, Rak expression is elevated in G1, and transfection of Rak into NIH 3T3 cells results in a significant decrease in the number of emerging colonies. Thus, Rak is a tyrosine kinase with growth suppressing activity that may function, in part, through its interaction with pRb.

Links

PubMed

Keywords

3T3 Cells; Amino Acid Sequence; Animals; Humans; Mice; Molecular Sequence Data; Neoplasm Proteins; Phosphorylation; Protein-Tyrosine Kinases/metabolism; Retinoblastoma Protein/metabolism; Tumor Cells, Cultured; src-Family Kinases

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:RB

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P42685

F

Seeded From UniProt

complete

HUMAN:FRK

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P06400

F

Seeded From UniProt

complete

HUMAN:FRK

involved_in

GO:0008285: negative regulation of cell population proliferation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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