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HUMAN:FOXJ1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | FOXJ1 (synonyms: FKHL13, HFH4) | |
Protein Name(s) | Forkhead box protein J1
Forkhead-related protein FKHL13 Hepatocyte nuclear factor 3 forkhead homolog 4 HFH-4 | |
External Links | ||
UniProt | Q92949 | |
EMBL | U69537 X99349 X99350 X99351 AJ272064 BC046460 | |
CCDS | CCDS32739.1 | |
RefSeq | NP_001445.2 | |
UniGene | Hs.651204 | |
ProteinModelPortal | Q92949 | |
SMR | Q92949 | |
BioGrid | 108591 | |
IntAct | Q92949 | |
STRING | 9606.ENSP00000323880 | |
DMDM | 12644465 | |
PaxDb | Q92949 | |
PRIDE | Q92949 | |
Ensembl | ENST00000322957 | |
GeneID | 2302 | |
KEGG | hsa:2302 | |
UCSC | uc002jqx.3 | |
CTD | 2302 | |
GeneCards | GC17M074132 | |
HGNC | HGNC:3816 | |
HPA | HPA005714 | |
MIM | 602291 607154 | |
neXtProt | NX_Q92949 | |
PharmGKB | PA28233 | |
eggNOG | COG5025 | |
GeneTree | ENSGT00760000118794 | |
HOGENOM | HOG000112631 | |
HOVERGEN | HBG056832 | |
InParanoid | Q92949 | |
KO | K09402 | |
OMA | HGHHIDC | |
OrthoDB | EOG7T4MKM | |
PhylomeDB | Q92949 | |
TreeFam | TF333250 | |
GeneWiki | FOXJ1 | |
GenomeRNAi | 2302 | |
NextBio | 9347 | |
PRO | PR:Q92949 | |
Proteomes | UP000005640 | |
Bgee | Q92949 | |
CleanEx | HS_FOXJ1 | |
ExpressionAtlas | Q92949 | |
Genevestigator | Q92949 | |
GO | GO:0005634 GO:0003677 GO:0003700 GO:0000976 GO:0030036 GO:0032862 GO:0007420 GO:0002508 GO:0042384 GO:0060271 GO:0060429 GO:0035089 GO:0072016 GO:0006959 GO:0060972 GO:0050900 GO:0060428 GO:0035502 GO:0050869 GO:0002635 GO:0002924 GO:0045409 GO:0032088 GO:0033085 GO:0042130 GO:0000122 GO:0007389 GO:0002897 GO:1901248 GO:0045944 GO:0007283 GO:0006351 | |
Gene3D | 1.10.10.10 | |
InterPro | IPR001766 IPR018122 IPR011991 | |
Pfam | PF00250 | |
PRINTS | PR00053 | |
SMART | SM00339 | |
PROSITE | PS00657 PS00658 PS50039 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
occurs_at:(SO:0001952) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1901248 |
positive regulation of lung ciliated cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0072016 |
glomerular parietal epithelial cell development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060429 |
epithelium development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_in:(CL:0000706) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060428 |
lung epithelium development |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060428 |
lung epithelium development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050869 |
negative regulation of B cell activation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045409 |
negative regulation of interleukin-6 biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035502 |
metanephric part of ureteric bud development |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035089 |
establishment of apical/basal cell polarity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033085 |
negative regulation of T cell differentiation in thymus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007420 |
brain development |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007420 |
brain development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
occurs_in:(CL:0000706) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007389 |
pattern specification process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006959 |
humoral immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002924 |
negative regulation of humoral immune response mediated by circulating immunoglobulin |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002897 |
positive regulation of central B cell tolerance induction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002635 |
negative regulation of germinal center formation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002508 |
central tolerance induction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060972 |
left/right pattern formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060429 |
epithelium development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060271 |
cilium assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050900 |
leukocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050869 |
negative regulation of B cell activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045409 |
negative regulation of interleukin-6 biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0044458 |
motile cilium assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042130 |
negative regulation of T cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035089 |
establishment of apical/basal cell polarity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0033085 |
negative regulation of T cell differentiation in thymus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032088 |
negative regulation of NF-kappaB transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030856 |
regulation of epithelial cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007507 |
heart development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007420 |
brain development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007368 |
determination of left/right symmetry |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006959 |
humoral immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002924 |
negative regulation of humoral immune response mediated by circulating immunoglobulin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002897 |
positive regulation of central B cell tolerance induction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002635 |
negative regulation of germinal center formation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002508 |
central tolerance induction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0001228 |
DNA-binding transcription activator activity, RNA polymerase II-specific |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000978 |
RNA polymerase II proximal promoter sequence-specific DNA binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61660 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0043565 |
sequence-specific DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030030 |
cell projection organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
- ↑ Turner, J et al. (2011) Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. Am. J. Respir. Cell Mol. Biol. 44 276-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Pelletier, GJ et al. (1998) A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am. J. Physiol. 274 L351-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Murphy, DB et al. (1997) The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression. Genomics 40 462-9 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Lim, L et al. (1997) The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 94 3094-9 PubMed GONUTS page
- ↑ LeSimple, P et al. (2007) Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation. Am. J. Respir. Cell Mol. Biol. 36 296-303 PubMed GONUTS page
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- GO:0032088 ! negative regulation of NF-kappaB transcription factor activity
- GO:0045409 ! negative regulation of interleukin-6 biosynthetic process
- GO:0002924 ! negative regulation of humoral immune response mediated by circulating immunoglobulin
- GO:0002635 ! negative regulation of germinal center formation
- GO:0000122 ! negative regulation of transcription by RNA polymerase II
- GO:0033085 ! negative regulation of T cell differentiation in thymus
- GO:0050869 ! negative regulation of B cell activation
- GO:0042130 ! negative regulation of T cell proliferation
- GO:0005634 ! nucleus
p
- GO:0007389 ! pattern specification process
- GO:1901248 ! positive regulation of lung ciliated cell differentiation
- GO:0002897 ! positive regulation of central B cell tolerance induction
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0045893 ! positive regulation of DNA-templated transcription
- Primates
r