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HUMAN:FOXJ1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FOXJ1 (synonyms: FKHL13, HFH4)
Protein Name(s) Forkhead box protein J1

Forkhead-related protein FKHL13 Hepatocyte nuclear factor 3 forkhead homolog 4 HFH-4

External Links
UniProt Q92949
EMBL U69537
X99349
X99350
X99351
AJ272064
BC046460
CCDS CCDS32739.1
RefSeq NP_001445.2
UniGene Hs.651204
ProteinModelPortal Q92949
SMR Q92949
BioGrid 108591
IntAct Q92949
STRING 9606.ENSP00000323880
DMDM 12644465
PaxDb Q92949
PRIDE Q92949
Ensembl ENST00000322957
GeneID 2302
KEGG hsa:2302
UCSC uc002jqx.3
CTD 2302
GeneCards GC17M074132
HGNC HGNC:3816
HPA HPA005714
MIM 602291
607154
neXtProt NX_Q92949
PharmGKB PA28233
eggNOG COG5025
GeneTree ENSGT00760000118794
HOGENOM HOG000112631
HOVERGEN HBG056832
InParanoid Q92949
KO K09402
OMA HGHHIDC
OrthoDB EOG7T4MKM
PhylomeDB Q92949
TreeFam TF333250
GeneWiki FOXJ1
GenomeRNAi 2302
NextBio 9347
PRO PR:Q92949
Proteomes UP000005640
Bgee Q92949
CleanEx HS_FOXJ1
ExpressionAtlas Q92949
Genevestigator Q92949
GO GO:0005634
GO:0003677
GO:0003700
GO:0000976
GO:0030036
GO:0032862
GO:0007420
GO:0002508
GO:0042384
GO:0060271
GO:0060429
GO:0035089
GO:0072016
GO:0006959
GO:0060972
GO:0050900
GO:0060428
GO:0035502
GO:0050869
GO:0002635
GO:0002924
GO:0045409
GO:0032088
GO:0033085
GO:0042130
GO:0000122
GO:0007389
GO:0002897
GO:1901248
GO:0045944
GO:0007283
GO:0006351
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00657
PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR001766

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q61660

F

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:1901248

positive regulation of lung ciliated cell differentiation

PMID:20539013[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072016

glomerular parietal epithelial cell development

PMID:9530170[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060429

epithelium development

PMID:9073514[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

occurs_in:(CL:0000706)

Seeded From UniProt

complete

involved_in

GO:0060428

lung epithelium development

PMID:9096351[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060428

lung epithelium development

PMID:9530170[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0050869

negative regulation of B cell activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:9096351[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045409

negative regulation of interleukin-6 biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0035502

metanephric part of ureteric bud development

PMID:9530170[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035089

establishment of apical/basal cell polarity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0033085

negative regulation of T cell differentiation in thymus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:9096351[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:9073514[4]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

occurs_in:(CL:0000706)

Seeded From UniProt

complete

involved_in

GO:0007389

pattern specification process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17008636[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002924

negative regulation of humoral immune response mediated by circulating immunoglobulin

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0002897

positive regulation of central B cell tolerance induction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0002635

negative regulation of germinal center formation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0002508

central tolerance induction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:9096351[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q61660

P

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

PMID:9073514[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:9073514[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

PMID:9073514[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0060972

left/right pattern formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0060429

epithelium development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0060271

cilium assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0050900

leukocyte migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0050869

negative regulation of B cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0045409

negative regulation of interleukin-6 biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0044458

motile cilium assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0042130

negative regulation of T cell proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0035089

establishment of apical/basal cell polarity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0033085

negative regulation of T cell differentiation in thymus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0032088

negative regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0030856

regulation of epithelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0030036

actin cytoskeleton organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0007368

determination of left/right symmetry

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0006959

humoral immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

C

Seeded From UniProt

complete

involved_in

GO:0002924

negative regulation of humoral immune response mediated by circulating immunoglobulin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0002897

positive regulation of central B cell tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0002635

negative regulation of germinal center formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

involved_in

GO:0002508

central tolerance induction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

F

Seeded From UniProt

complete

involved_in

GO:0000122

negative regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61660
ensembl:ENSMUSP00000038351

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0030030

cell projection organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0970

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. Turner, J et al. (2011) Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium. Am. J. Respir. Cell Mol. Biol. 44 276-84 PubMed GONUTS page
  3. 3.0 3.1 3.2 Pelletier, GJ et al. (1998) A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium. Am. J. Physiol. 274 L351-9 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Murphy, DB et al. (1997) The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression. Genomics 40 462-9 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Lim, L et al. (1997) The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 94 3094-9 PubMed GONUTS page
  6. LeSimple, P et al. (2007) Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation. Am. J. Respir. Cell Mol. Biol. 36 296-303 PubMed GONUTS page