HUMAN:FKBP4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FKBP4 (synonyms: FKBP52)
Protein Name(s)	Peptidyl-prolyl cis-trans isomerase FKBP4 PPIase FKBP4 51 kDa FK506-binding protein FKBP51 52 kDa FK506-binding protein 52 kDa FKBP FKBP-52 59 kDa immunophilin p59 FK506-binding protein 4 FKBP-4 FKBP59 HSP-binding immunophilin HBI Immunophilin FKBP52 Rotamase Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
External Links
UniProt	Q02790
EMBL	M88279 AC005841 CH471116 CH471116 BC001786 BC007924
CCDS	CCDS8512.1
PIR	A46372
RefSeq	NP_002005.1
UniGene	Hs.524183 Hs.713721
PDB	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY
PDBsum	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY
ProteinModelPortal	Q02790
SMR	Q02790
BioGrid	108578
DIP	DIP-50866N
IntAct	Q02790
MINT	MINT-3024864
STRING	9606.ENSP00000001008
BindingDB	Q02790
ChEMBL	CHEMBL4050
PhosphoSite	Q02790
DMDM	399866
REPRODUCTION-2DPAGE	IPI00219005
MaxQB	Q02790
PaxDb	Q02790
PeptideAtlas	Q02790
PRIDE	Q02790
DNASU	2288
Ensembl	ENST00000001008
GeneID	2288
KEGG	hsa:2288
UCSC	uc001qkz.3
CTD	2288
GeneCards	GC12P002904
H-InvDB	HIX0010330
HGNC	HGNC:3720
HPA	CAB017441 HPA006148
MIM	600611
neXtProt	NX_Q02790
PharmGKB	PA28161
eggNOG	COG0545
GeneTree	ENSGT00760000119159
HOGENOM	HOG000256916
HOVERGEN	HBG051624
InParanoid	Q02790
KO	K09571
OMA	NAELKYE
PhylomeDB	Q02790
TreeFam	TF354214
Reactome	REACT_200624
ChiTaRS	FKBP4
EvolutionaryTrace	Q02790
GeneWiki	FKBP52
GenomeRNAi	2288
NextBio	9299
PRO	PR:Q02790
Proteomes	UP000005640
Bgee	Q02790
CleanEx	HS_FKBP4
ExpressionAtlas	Q02790
Genevestigator	Q02790
GO	GO:0044295 GO:0005737 GO:0005829 GO:0005789 GO:0070062 GO:0005874 GO:0005739 GO:0043025 GO:0005634 GO:0048471 GO:0005524 GO:0005528 GO:0005525 GO:0031072 GO:0003755 GO:0044822 GO:0030674 GO:0030521 GO:0061077 GO:0006825 GO:0007566 GO:0046661 GO:0031115 GO:0031111 GO:0010977 GO:0030850 GO:0031503 GO:0006457 GO:0000413 GO:0006463
Gene3D	1.25.40.10
InterPro	IPR023566 IPR001179 IPR013026 IPR011990 IPR001440 IPR019734
PANTHER	PTHR10516
Pfam	PF00254 PF00515
SMART	SM00028
PROSITE	PS50059 PS50005 PS50293

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:19056867^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	PMID:11350175^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVC8	C		Seeded From UniProt	complete
involved_in	GO:0031111	negative regulation of microtubule polymerization or depolymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27124	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:9660753^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07900	F		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P27124	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QVC8	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:11350175^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054102 UniProtKB:Q02790 UniProtKB:Q13451	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054102 UniProtKB:P62942 UniProtKB:P68106 UniProtKB:Q38931 UniProtKB:Q8I4V8	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000188340 MGI:MGI:1336205 PANTHER:PTN000054102 PomBase:SPAC27F1.06c SGD:S000005079 UniProtKB:P18203 UniProtKB:P62942 UniProtKB:P68106 UniProtKB:Q02790 UniProtKB:Q13451 UniProtKB:Q8I4V8 WB:WBGene00001431	F		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054102 UniProtKB:P62942 UniProtKB:P68106 WB:WBGene00001431	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	F		Seeded From UniProt	complete
involved_in	GO:0048608	reproductive structure development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
involved_in	GO:0046661	male sex differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
enables	GO:0035259	glucocorticoid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	F		Seeded From UniProt	complete
involved_in	GO:0031503	protein-containing complex localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	F		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
involved_in	GO:0030521	androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
involved_in	GO:0007566	embryo implantation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
involved_in	GO:0006463	steroid hormone receptor complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P30416 ensembl:ENSMUSP00000032508	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	F		Seeded From UniProt	complete
part_of	GO:0044295	axonal growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	C		Seeded From UniProt	complete
enables	GO:0032767	copper-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	F		Seeded From UniProt	complete
involved_in	GO:0031115	negative regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	P		Seeded From UniProt	complete
involved_in	GO:0006825	copper ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QVC8 ensembl:ENSRNOP00000008737	C		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031212	P		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031212	F		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031212	F		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031212	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.2.1.8	F		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	PMID:2378870^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	PMID:1279700^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:2378870^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	PMID:1376003^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5618110 Reactome:R-HSA-5618099 Reactome:R-HSA-5618085 Reactome:R-HSA-5618080 Reactome:R-HSA-5618073	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9038161 Reactome:R-HSA-5618093 Reactome:R-HSA-5618080 Reactome:R-HSA-5324617	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0697	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^2.0 ^2.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^3.0 ^3.1 Pirkl, F & Buchner, J (2001) Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J. Mol. Biol. 308 795-806 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ Young, JC et al. (1998) Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J. Biol. Chem. 273 18007-10 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Sanchez, ER et al. (1990) The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins. Biochemistry 29 5145-52 PubMed GONUTS page
↑ Peattie, DA et al. (1992) Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc. Natl. Acad. Sci. U.S.A. 89 10974-8 PubMed GONUTS page
↑ Tai, PK et al. (1992) Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 256 1315-8 PubMed GONUTS page

[PMID:19056867-1] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-2] 2.0 ^2.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:11350175-3] 3.0 ^3.1 Pirkl, F & Buchner, J (2001) Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40. J. Mol. Biol. 308 795-806 PubMed GONUTS page

[PMID:22658674-4] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:9660753-5] Young, JC et al. (1998) Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90. J. Biol. Chem. 273 18007-10 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2378870-7] 7.0 ^7.1 Sanchez, ER et al. (1990) The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins. Biochemistry 29 5145-52 PubMed GONUTS page

[PMID:1279700-8] Peattie, DA et al. (1992) Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc. Natl. Acad. Sci. U.S.A. 89 10974-8 PubMed GONUTS page

[PMID:1376003-9] Tai, PK et al. (1992) Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 256 1315-8 PubMed GONUTS page

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HUMAN:FKBP4

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