HUMAN:FGFR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FGFR2 (synonyms: BEK, KGFR, KSAM)
Protein Name(s)	Fibroblast growth factor receptor 2 FGFR-2 K-sam KGFR Keratinocyte growth factor receptor
External Links
UniProt	P21802
EMBL	X52832 M55614 X56191 M35718 M87770 M87771 M87772 M97193 U11814 M80634 Z71929 AB030073 AB030074 AB030075 AB030076 AB030077 AB030078 AF360695 AF410480 AF360695 AF410480 AF360695 AF410480 AF360695 AF410480 AF360695 AF410480 AF487553 AB084153 DQ493927 AK294026 AC009988 BC039243 AF169399 AF169399 AF097353 AF097341 AF097342 AF097343 AF097345 AF097346 AF097347 AF097348 AF097349 AF097350 AF097351 AF097352 AF097353 AF097341 AF097342 AF097344 AF097345 AF097346 AF097347 AF097348 AF097349 AF097350 AF097351 AF097352 AF097340 AF097337 AF097338 AF097339 AF097354 AF097341 S82438 Y17131 L49237 L49242 L49238 L49239 L49240 L49241
CCDS	CCDS31298.1 CCDS44485.1 CCDS44486.1 CCDS44487.1 CCDS44488.1 CCDS44489.1 CCDS53584.1 CCDS7620.2
PIR	A35969 A42691 A45081 C42691 S16236
RefSeq	NP_000132.3 NP_001138385.1 NP_001138386.1 NP_001138387.1 NP_001138388.1 NP_001138389.1 NP_001138390.1 NP_001138391.1 NP_075259.4 NP_075418.1
UniGene	Hs.533683
PDB	1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J23 4J95 4J96 4J97 4J98 4J99
PDBsum	1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU 3OJ2 3OJM 3RI1 4J23 4J95 4J96 4J97 4J98 4J99
ProteinModelPortal	P21802
SMR	P21802
BioGrid	108554
DIP	DIP-3788N
IntAct	P21802
MINT	MINT-118359
BindingDB	P21802
ChEMBL	CHEMBL4142
DrugBank	DB00039 DB08901 DB08896 DB01041
GuidetoPHARMACOLOGY	1809
MEROPS	I43.001
PhosphoSite	P21802
DMDM	120049
MaxQB	P21802
PaxDb	P21802
PRIDE	P21802
Ensembl	ENST00000346997 ENST00000356226 ENST00000357555 ENST00000358487 ENST00000359354 ENST00000360144 ENST00000369056 ENST00000369058 ENST00000369060 ENST00000369061 ENST00000457416
GeneID	2263
KEGG	hsa:2263
UCSC	uc001lfg.4 uc001lfn.5 uc010qtl.2 uc021pzv.1 uc021pzx.1 uc021pzy.1 uc021qaa.1 uc021qab.1 uc021qac.1
CTD	2263
GeneCards	GC10M123223
GeneReviews	FGFR2
HGNC	HGNC:3689
HPA	CAB010886 HPA035305 HPA056562
MIM	101200 101600 123150 123500 123790 149730 176943 207410 609579 614592
neXtProt	NX_P21802
Orphanet	83 87 207 1555 168624 313855 1540 2363 93258 93259 93260 794
PharmGKB	PA28128
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000263410
HOVERGEN	HBG000345
InParanoid	P21802
KO	K05093
OrthoDB	EOG7NGQ9N
PhylomeDB	P21802
TreeFam	TF316307
BRENDA	2.7.10.1
Reactome	REACT_111184 REACT_120863 REACT_121255 REACT_121398 REACT_147727 REACT_21247 REACT_21270 REACT_21310 REACT_21374 REACT_75829 REACT_9413 REACT_9416 REACT_976
SignaLink	P21802
ChiTaRS	FGFR2
EvolutionaryTrace	P21802
GeneWiki	Fibroblast_growth_factor_receptor_2
GenomeRNAi	2263
NextBio	9189
PRO	PR:P21802
Proteomes	UP000005640
Bgee	P21802
ExpressionAtlas	P21802
Genevestigator	P21802
GO	GO:0005938 GO:0009986 GO:0005737 GO:0016023 GO:0060076 GO:0005576 GO:0005794 GO:0016021 GO:0005887 GO:0043231 GO:0016020 GO:0005634 GO:0005886 GO:0005524 GO:0017134 GO:0005007 GO:0008201 GO:0042803 GO:0004713 GO:0001525 GO:0006915 GO:0007409 GO:0060348 GO:0030282 GO:0060349 GO:0060667 GO:0060670 GO:0060442 GO:0060445 GO:0048755 GO:0060449 GO:0045165 GO:0007267 GO:0060365 GO:0048565 GO:0048701 GO:0048557 GO:0048568 GO:0048562 GO:0009880 GO:0061031 GO:0007173 GO:0048730 GO:0030855 GO:0060664 GO:0001837 GO:0038095 GO:0008543 GO:0035603 GO:0060595 GO:0035602 GO:0035607 GO:0035604 GO:0022612 GO:0031069 GO:0001701 GO:0045087 GO:0042472 GO:0008286 GO:0032808 GO:0060601 GO:0070307 GO:0060174 GO:0048286 GO:0030324 GO:0060463 GO:0060484 GO:0060615 GO:0003149 GO:0048762 GO:0060915 GO:0060916 GO:0048333 GO:0030901 GO:0016331 GO:0035264 GO:0050680 GO:0045839 GO:0000122 GO:0007528 GO:0048011 GO:0042476 GO:0021769 GO:0035265 GO:0009887 GO:0030916 GO:0003148 GO:0018108 GO:0048015 GO:0090263 GO:0060045 GO:0045787 GO:0051781 GO:0008284 GO:0050679 GO:0060501 GO:0070374 GO:0043410 GO:0002053 GO:0010518 GO:0048661 GO:0045944 GO:0030177 GO:0009791 GO:0060527 GO:0060523 GO:0060512 GO:0046777 GO:0021860 GO:0060687 GO:0010453 GO:0070372 GO:0040036 GO:0060688 GO:0040014 GO:0045667 GO:0033688 GO:0051150 GO:0008589 GO:0048608 GO:0048705 GO:0060529 GO:0048489 GO:0001657 GO:0055010 GO:0021847
Gene3D	2.60.40.10
InterPro	IPR028175 IPR016248 IPR007110 IPR013783 IPR013098 IPR003598 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635
PANTHER	PTHR24416:SF130
Pfam	PF07679 PF07714
PIRSF	PIRSF000628
PRINTS	PR00109
SMART	SM00408 SM00219
SUPFAM	SSF56112
PROSITE	PS50835 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005104	fibroblast growth factor receptor binding	PMID:20436882^[1]	ECO:0000315			F		Figure 1. Two thirds of patients with Apert syndrome exhibit the Ser252Trp FGFR2 mutation, one third of patients the Pro253Arg FGFR2 mutation.	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:7874170^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:7987400^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060916	mesenchymal cell proliferation involved in lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060915	mesenchymal cell differentiation involved in lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060688	regulation of morphogenesis of a branching structure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060687	regulation of branching involved in prostate gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060670	branching involved in labyrinthine layer morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060667	branch elongation involved in salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060615	mammary gland bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060601	lateral sprouting from an epithelium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060529	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060523	prostate epithelial cord elongation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060512	prostate gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060484	lung-associated mesenchyme development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060463	lung lobe morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060449	bud elongation involved in lung branching	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060445	branching involved in salivary gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060442	branching involved in prostate gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060349	bone morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0060174	limb bud formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	C		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0051781	positive regulation of cell division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0051150	regulation of smooth muscle cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048755	branching morphogenesis of a nerve	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048730	epidermis morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048608	reproductive structure development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048562	embryonic organ morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048557	embryonic digestive tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:15629145^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:15629145^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16844695^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21802	F		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0035604	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0035603	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0035602	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0035265	organ growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0032808	lacrimal gland development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:17959718^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0030901	midbrain development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0030282	bone mineralization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0022612	gland morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0021860	pyramidal neuron development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0021847	ventricular zone neuroblast division	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0021769	orbitofrontal cortex development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:16844695^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:15629145^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:8663044^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016331	morphogenesis of embryonic epithelium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:1697263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8676562^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010518	positive regulation of phospholipase activity	PMID:16844695^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010453	regulation of cell fate commitment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:16597614^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000192) part_of:(UBERON:0001255)\|part_of:(CL:0000731)	Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0009880	embryonic pattern specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0008589	regulation of smoothened signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:15629145^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15629145^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:17471512^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:16844695^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:15629145^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16597614^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000192) part_of:(UBERON:0001255)\|part_of:(CL:0000731)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17471512^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16597614^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000731) part_of:(UBERON:0000056)\|part_of:(CL:0000731) part_of:(UBERON:0001255)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17471512^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:15629145^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:8663044^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:1400433^[12]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:1697263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:8676562^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:1697263^[8]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003149	membranous septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21803	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-030323-1	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 PANTHER:PTN001230353 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95522 MGI:MGI:95524 PANTHER:PTN000699279 RGD:2611 RGD:620714 UniProtKB:P11362 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:8386828^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12034	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:10830168^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P55075	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31371	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21781	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12304	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P11487	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10767	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05230	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P55075	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P31371	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P21781	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P12304	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P11487	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P10767	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08620	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8663044^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05230	P		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	PMID:10830168^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09038	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0048661	positive regulation of smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0048333	mesodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	C		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	C		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	F		Seeded From UniProt	complete
involved_in	GO:0003416	endochondral bone growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LSG7 ensembl:ENSRNOP00000059005	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005007	fibroblast growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016248 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016248 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	P		Seeded From UniProt	complete
	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:7987400^[3]	ECO:0000315			P		Figure 4. Direct sequencing of Crouzon syndrome FGFR2 mutations.	complete CACAO 3435
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016248	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19060208^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21802-1	F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:19224135^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
enables	GO:0017134	fibroblast growth factor binding	PMID:11923311^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	PMID:15190072^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045667	regulation of osteoblast differentiation	PMID:15190072^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033688	regulation of osteoblast proliferation	PMID:15190072^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:R-HSA-5654738 Reactome:R-HSA-190377 Reactome:R-HSA-190375	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-8853328 Reactome:R-HSA-8853319 Reactome:R-HSA-8853313 Reactome:R-HSA-5672965 Reactome:R-HSA-5655343 Reactome:R-HSA-5655339 Reactome:R-HSA-5655323 Reactome:R-HSA-5655320 Reactome:R-HSA-5655301 Reactome:R-HSA-5655268 Reactome:R-HSA-5655245 Reactome:R-HSA-5655241 Reactome:R-HSA-5655233 Reactome:R-HSA-5654748 Reactome:R-HSA-5654729 Reactome:R-HSA-5654701 Reactome:R-HSA-5654697 Reactome:R-HSA-5654677 Reactome:R-HSA-5654622 Reactome:R-HSA-5654620 Reactome:R-HSA-5654618 Reactome:R-HSA-5654615 Reactome:R-HSA-5654614 Reactome:R-HSA-5654612 Reactome:R-HSA-5654608 Reactome:R-HSA-5654607 Reactome:R-HSA-5654605 Reactome:R-HSA-5654603 Reactome:R-HSA-5654562 Reactome:R-HSA-5654407 Reactome:R-HSA-5654406 Reactome:R-HSA-5654404 Reactome:R-HSA-5654402 Reactome:R-HSA-5654399 Reactome:R-HSA-5654397 Reactome:R-HSA-5654159 Reactome:R-HSA-5654157 Reactome:R-HSA-5654147 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-2077424 Reactome:R-HSA-2067713 Reactome:R-HSA-2033490 Reactome:R-HSA-2033488 Reactome:R-HSA-2033486 Reactome:R-HSA-2033479 Reactome:R-HSA-2033474 Reactome:R-HSA-2033472 Reactome:R-HSA-2029992 Reactome:R-HSA-2029989 Reactome:R-HSA-2029988 Reactome:R-HSA-2029984 Reactome:R-HSA-2029983 Reactome:R-HSA-190413 Reactome:R-HSA-190408 Reactome:R-HSA-190260 Reactome:R-HSA-190258 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Melnik, BC (2009) Role of FGFR2-signaling in the pathogenesis of acne. Dermatoendocrinol 1 141-56 PubMed GONUTS page
↑ Jabs, EW et al. (1994) Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat. Genet. 8 275-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Reardon, W et al. (1994) Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nat. Genet. 8 98-103 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Ceridono, M et al. (2005) Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis. Biochem. Biophys. Res. Commun. 327 523-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Hatch, NE et al. (2006) Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J. Biol. Chem. 281 27292-305 PubMed GONUTS page
↑ Patel, VN et al. (2007) Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development 134 4177-86 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Dionne, CA et al. (1990) Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J. 9 2685-92 PubMed GONUTS page
↑ ^9.0 ^9.1 Wada, C et al. (1996) [Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome]. Rinsho Byori 44 435-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Zhang, D et al. (2006) FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract. Am. J. Physiol. Renal Physiol. 291 F481-94 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kosman, J et al. (2007) Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells. J. Cell. Biochem. 102 769-85 PubMed GONUTS page
↑ Dell, KR & Williams, LT (1992) A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity. J. Biol. Chem. 267 21225-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Clements, DA et al. (1993) Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Oncogene 8 1311-6 PubMed GONUTS page
↑ ^15.0 ^15.1 Plotnikov, AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101 413-24 PubMed GONUTS page
↑ Chen, H et al. (2008) A crystallographic snapshot of tyrosine trans-phosphorylation in action. Proc. Natl. Acad. Sci. U.S.A. 105 19660-5 PubMed GONUTS page
↑ Wang, J et al. (2009) Construction and characterization of a high activity mutant of human keratinocyte growth factor-2. Biotechnol. Lett. 31 797-802 PubMed GONUTS page
↑ Bagai, S et al. (2002) Fibroblast growth factor-10 is a mitogen for urothelial cells. J. Biol. Chem. 277 23828-37 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Kaabeche, K et al. (2004) Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J. Biol. Chem. 279 36259-67 PubMed GONUTS page

[PMID:20436882-1] Melnik, BC (2009) Role of FGFR2-signaling in the pathogenesis of acne. Dermatoendocrinol 1 141-56 PubMed GONUTS page

[PMID:7874170-2] Jabs, EW et al. (1994) Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat. Genet. 8 275-9 PubMed GONUTS page

[PMID:7987400-3] 3.0 ^3.1 Reardon, W et al. (1994) Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nat. Genet. 8 98-103 PubMed GONUTS page

[PMID:15629145-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Ceridono, M et al. (2005) Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis. Biochem. Biophys. Res. Commun. 327 523-32 PubMed GONUTS page

[PMID:16844695-5] 5.0 ^5.1 ^5.2 ^5.3 Hatch, NE et al. (2006) Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J. Biol. Chem. 281 27292-305 PubMed GONUTS page

[PMID:17959718-6] Patel, VN et al. (2007) Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development 134 4177-86 PubMed GONUTS page

[PMID:8663044-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 ^7.20 ^7.21 Ornitz, DM et al. (1996) Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271 15292-7 PubMed GONUTS page

[PMID:1697263-8] 8.0 ^8.1 ^8.2 Dionne, CA et al. (1990) Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J. 9 2685-92 PubMed GONUTS page

[PMID:8676562-9] 9.0 ^9.1 Wada, C et al. (1996) [Nucleotide sequences at intron 6 and exon 7 junction of fibroblast growth factor receptor 2 and rapid mutational analysis in Apert syndrome]. Rinsho Byori 44 435-8 PubMed GONUTS page

[PMID:16597614-10] 10.0 ^10.1 ^10.2 Zhang, D et al. (2006) FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract. Am. J. Physiol. Renal Physiol. 291 F481-94 PubMed GONUTS page

[PMID:17471512-11] 11.0 ^11.1 ^11.2 Kosman, J et al. (2007) Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells. J. Cell. Biochem. 102 769-85 PubMed GONUTS page

[PMID:1400433-12] Dell, KR & Williams, LT (1992) A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity. J. Biol. Chem. 267 21225-9 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 ^13.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8386828-14] Clements, DA et al. (1993) Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. Oncogene 8 1311-6 PubMed GONUTS page

[PMID:10830168-15] 15.0 ^15.1 Plotnikov, AN et al. (2000) Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell 101 413-24 PubMed GONUTS page

[PMID:19060208-16] Chen, H et al. (2008) A crystallographic snapshot of tyrosine trans-phosphorylation in action. Proc. Natl. Acad. Sci. U.S.A. 105 19660-5 PubMed GONUTS page

[PMID:19224135-17] Wang, J et al. (2009) Construction and characterization of a high activity mutant of human keratinocyte growth factor-2. Biotechnol. Lett. 31 797-802 PubMed GONUTS page

[PMID:11923311-18] Bagai, S et al. (2002) Fibroblast growth factor-10 is a mitogen for urothelial cells. J. Biol. Chem. 277 23828-37 PubMed GONUTS page

[PMID:15190072-19] 19.0 ^19.1 ^19.2 Kaabeche, K et al. (2004) Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J. Biol. Chem. 279 36259-67 PubMed GONUTS page

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