HUMAN:FER

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FER (synonyms: TYK3)
Protein Name(s)	Tyrosine-protein kinase Fer Feline encephalitis virus-related kinase FER Fujinami poultry sarcoma/Feline sarcoma-related protein Fer Proto-oncogene c-Fer Tyrosine kinase 3 p94-Fer
External Links
UniProt	P16591
EMBL	J03358 JQ412173 AK299855 AK315234 AC034207 AC008871 AC109481 AC008955 AC010228 AC011421 AC116428 CH471086
CCDS	CCDS4098.1
PIR	A31943
RefSeq	NP_005237.2 XP_006714635.1 XP_006714636.1
UniGene	Hs.221472
PDB	2KK6
PDBsum	2KK6
ProteinModelPortal	P16591
SMR	P16591
BioGrid	108532
IntAct	P16591
MINT	MINT-261636
STRING	9606.ENSP00000281092
BindingDB	P16591
ChEMBL	CHEMBL3982
GuidetoPHARMACOLOGY	2022
PhosphoSite	P16591
DMDM	97536202
MaxQB	P16591
PaxDb	P16591
PeptideAtlas	P16591
PRIDE	P16591
DNASU	2241
Ensembl	ENST00000281092 ENST00000438717 ENST00000618353
GeneID	2241
KEGG	hsa:2241
UCSC	uc003kop.1 uc031skp.1
CTD	2241
GeneCards	GC05P108111
HGNC	HGNC:3655
HPA	CAB022464 HPA007641
MIM	176942
neXtProt	NX_P16591
PharmGKB	PA28095
eggNOG	COG0515
GeneTree	ENSGT00760000119011
HOGENOM	HOG000059550
HOVERGEN	HBG005655
InParanoid	P16591
KO	K08889
OMA	MTLRVKS
OrthoDB	EOG708VXW
PhylomeDB	P16591
TreeFam	TF315363
BRENDA	2.7.10.2
Reactome	REACT_111040
SignaLink	P16591
ChiTaRS	FER
EvolutionaryTrace	P16591
GeneWiki	FER_(gene)
GenomeRNAi	2241
NextBio	9065
PRO	PR:P16591
Proteomes	UP000005640
Bgee	P16591
CleanEx	HS_FER
ExpressionAtlas	P16591
Genevestigator	P16591
GO	GO:0005938 GO:0030054 GO:0042995 GO:0005737 GO:0005856 GO:0005829 GO:0031234 GO:0005634 GO:0005524 GO:0005154 GO:0008289 GO:0004715 GO:0004713 GO:0031532 GO:0007155 GO:0030154 GO:0008283 GO:0044331 GO:0032869 GO:0036006 GO:0034614 GO:0006935 GO:0019221 GO:0050904 GO:0035426 GO:0038095 GO:0045087 GO:0038028 GO:0070102 GO:0035556 GO:0038109 GO:0000226 GO:0000278 GO:0033007 GO:0038083 GO:0018108 GO:0048008 GO:0030838 GO:0030335 GO:0008284 GO:0051092 GO:0046777 GO:0006468 GO:0042127 GO:0042058 GO:0010762 GO:0010591 GO:0043304 GO:0001932 GO:0032496 GO:0036119 GO:0034446 GO:0042503
Gene3D	3.30.505.10
InterPro	IPR001060 IPR028539 IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR016250 IPR008266 IPR020635
PANTHER	PTHR24418:SF227
Pfam	PF00611 PF07714 PF00017
PIRSF	PIRSF000632
PRINTS	PR00401 PR00109
SMART	SM00055 SM00252 SM00219
SUPFAM	SSF55550 SSF56112
PROSITE	PS50133 PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008284	positive regulation of cell proliferation	PMID:25540073^[1]	ECO:0000315			P	Fig. 7 Decrease in proliferation index due to RNAi knockout of FER	complete CACAO 10817
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:25540073^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	PMID:19147545^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21518868^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050904	diapedesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:7623846^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:19147545^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	PMID:21518868^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038109	Kit signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0036119	response to platelet-derived growth factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	PMID:9722593^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035426	extracellular matrix-cell signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0033007	negative regulation of mast cell activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	PMID:19738202^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:19738202^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0030054	cell junction	PMID:12972546^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0030027	lamellipodium	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:9722593^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:12972546^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0015630	microtubule cytoskeleton	PMID:12972546^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
colocalizes_with	GO:0015629	actin cytoskeleton	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010591	regulation of lamellipodium assembly	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:22223638^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:1990274^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19147545^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	PMID:21518868^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:12972546^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:19738202^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70451	P	Seeded From UniProt	complete
colocalizes_with	GO:0000790	nuclear chromatin	PMID:1990274^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	PMID:22223638^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000226	microtubule cytoskeleton organization	PMID:12972546^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043304	regulation of mast cell degranulation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700775 UniProtKB:P07332	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231165 UniProtKB:P07332	P	Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105917 PANTHER:PTN000700801	P	Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231165 UniProtKB:P07332 UniProtKB:P16591	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105917 PANTHER:PTN000700775	P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105917 PANTHER:PTN000700775	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231165 UniProtKB:P07332 UniProtKB:P16591	F	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050904	diapedesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0044331	cell-cell adhesion mediated by cadherin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0038109	Kit signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0036119	response to platelet-derived growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0035426	extracellular matrix-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0033007	negative regulation of mast cell activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0010762	regulation of fibroblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
enables	GO:0008157	protein phosphatase 1 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	F	Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70451 ensembl:ENSMUSP00000000129	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016250 InterPro:IPR020635 InterPro:IPR028539 InterPro:IPR037452	F	Seeded From UniProt	complete
enables	GO:0005154	epidermal growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028539	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028539	P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016250	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028539	P	Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028539	P	Seeded From UniProt	complete
involved_in	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028539	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028539	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:2209086^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:2725517^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:2725517^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	PMID:11994747^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:20111072^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-205328	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F	Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966 UniProtKB-SubCell:SL-0280	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nizard, P et al. (2014) Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells. BMC Genomics 15 1169 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zoubeidi, A et al. (2009) The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. Mol. Cancer Res. 7 142-55 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Guo, C & Stark, GR (2011) FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. Proc. Natl. Acad. Sci. U.S.A. 108 7968-73 PubMed GONUTS page
↑ Kim, L & Wong, TW (1995) The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol. Cell. Biol. 15 4553-61 PubMed GONUTS page
↑ ^5.0 ^5.1 Kim, L & Wong, TW (1998) Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. J. Biol. Chem. 273 23542-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Itoh, T et al. (2009) The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal 2 ra52 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Kogata, N et al. (2003) Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. Mol. Biol. Cell 14 3553-64 PubMed GONUTS page
↑ ^8.0 ^8.1 Makovski, A et al. (2012) Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells. J. Biol. Chem. 287 6100-12 PubMed GONUTS page
↑ ^9.0 ^9.1 Hao, QL et al. (1991) Nuclear and cytoplasmic location of the FER tyrosine kinase. Mol. Cell. Biol. 11 1180-3 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Morris, C et al. (1990) The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Cytogenet. Cell Genet. 53 196-200 PubMed GONUTS page
↑ ^12.0 ^12.1 Hao, QL et al. (1989) Isolation and sequence analysis of a novel human tyrosine kinase gene. Mol. Cell. Biol. 9 1587-93 PubMed GONUTS page
↑ Greer, P (2002) Closing in on the biological functions of Fps/Fes and Fer. Nat. Rev. Mol. Cell Biol. 3 278-89 PubMed GONUTS page
↑ Voisset, E et al. (2010) FES kinases are required for oncogenic FLT3 signaling. Leukemia 24 721-8 PubMed GONUTS page

[PMID:25540073-1] 1.0 ^1.1 Nizard, P et al. (2014) Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells. BMC Genomics 15 1169 PubMed GONUTS page

[PMID:19147545-2] 2.0 ^2.1 ^2.2 Zoubeidi, A et al. (2009) The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth. Mol. Cancer Res. 7 142-55 PubMed GONUTS page

[PMID:21518868-3] 3.0 ^3.1 ^3.2 Guo, C & Stark, GR (2011) FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. Proc. Natl. Acad. Sci. U.S.A. 108 7968-73 PubMed GONUTS page

[PMID:7623846-4] Kim, L & Wong, TW (1995) The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol. Cell. Biol. 15 4553-61 PubMed GONUTS page

[PMID:9722593-5] 5.0 ^5.1 Kim, L & Wong, TW (1998) Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. J. Biol. Chem. 273 23542-8 PubMed GONUTS page

[PMID:19738202-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Itoh, T et al. (2009) The tyrosine kinase Fer is a downstream target of the PLD-PA pathway that regulates cell migration. Sci Signal 2 ra52 PubMed GONUTS page

[PMID:12972546-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Kogata, N et al. (2003) Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells. Mol. Biol. Cell 14 3553-64 PubMed GONUTS page

[PMID:22223638-8] 8.0 ^8.1 Makovski, A et al. (2012) Intronic promoter drives the BORIS-regulated expression of FerT in colon carcinoma cells. J. Biol. Chem. 287 6100-12 PubMed GONUTS page

[PMID:1990274-9] 9.0 ^9.1 Hao, QL et al. (1991) Nuclear and cytoplasmic location of the FER tyrosine kinase. Mol. Cell. Biol. 11 1180-3 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:2209086-11] Morris, C et al. (1990) The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Cytogenet. Cell Genet. 53 196-200 PubMed GONUTS page

[PMID:2725517-12] 12.0 ^12.1 Hao, QL et al. (1989) Isolation and sequence analysis of a novel human tyrosine kinase gene. Mol. Cell. Biol. 9 1587-93 PubMed GONUTS page

[PMID:11994747-13] Greer, P (2002) Closing in on the biological functions of Fps/Fes and Fer. Nat. Rev. Mol. Cell Biol. 3 278-89 PubMed GONUTS page

[PMID:20111072-14] Voisset, E et al. (2010) FES kinases are required for oncogenic FLT3 signaling. Leukemia 24 721-8 PubMed GONUTS page

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