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PMID:25540073
| Citation |
Nizard, P, Ezan, F, Bonnier, D, Le Meur, N, Langouët, S, Baffet, G, Arlot-Bonnemains, Y and Théret, N (2014) Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells. BMC Genomics 15:1169 |
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| Abstract |
Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment. Here, we propose a small interfering RNA genetic screen and an integrative approach to identify kinase networks involved in the proliferation of cancer cells. |
| Links |
PubMed PMC4367906 Online version:[1] |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0008284: positive regulation of cell proliferation |
ECO:0000315: |
P |
Fig. 7 Decrease in proliferation index due to RNAi knockout of FER |
complete | ||||
|
involved_in |
GO:0008284: positive regulation of cell population proliferation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0008284: positive regulation of cell proliferation |
ECO:0000315: |
P |
Fig. 7 Decrease in proliferation index due to RNAi knockout of CRKL |
complete | ||||
|
involved_in |
GO:0008284: positive regulation of cell population proliferation |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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