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HUMAN:FABP4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) FABP4
Protein Name(s) Fatty acid-binding protein, adipocyte

Adipocyte lipid-binding protein ALBP Adipocyte-type fatty acid-binding protein A-FABP AFABP Fatty acid-binding protein 4

External Links
UniProt P15090
EMBL J02874
BT006809
CR456903
CH471068
BC003672
CCDS CCDS6230.1
PIR A33363
RefSeq NP_001433.1
UniGene Hs.391561
PDB 1TOU
1TOW
2HNX
2NNQ
3FR2
3FR4
3FR5
3P6C
3P6D
3P6E
3P6F
3P6G
3P6H
3Q6L
3RZY
PDBsum 1TOU
1TOW
2HNX
2NNQ
3FR2
3FR4
3FR5
3P6C
3P6D
3P6E
3P6F
3P6G
3P6H
3Q6L
3RZY
ProteinModelPortal P15090
SMR P15090
BioGrid 108465
IntAct P15090
MINT MINT-1398507
STRING 9606.ENSP00000256104
BindingDB P15090
ChEMBL CHEMBL2083
PhosphoSite P15090
DMDM 119781
UCD-2DPAGE P15090
MaxQB P15090
PaxDb P15090
PeptideAtlas P15090
PRIDE P15090
DNASU 2167
Ensembl ENST00000256104
GeneID 2167
KEGG hsa:2167
UCSC uc003ycd.2
CTD 2167
GeneCards GC08M082390
HGNC HGNC:3559
HPA CAB024961
HPA002188
MIM 600434
neXtProt NX_P15090
PharmGKB PA27960
eggNOG NOG326764
GeneTree ENSGT00760000118898
HOGENOM HOG000004829
HOVERGEN HBG005633
InParanoid P15090
KO K08753
OMA GQEFDEI
OrthoDB EOG7NW6BZ
PhylomeDB P15090
TreeFam TF316894
Reactome REACT_27161
REACT_494
ChiTaRS FABP4
EvolutionaryTrace P15090
GeneWiki Adipocyte_protein_2
GenomeRNAi 2167
NextBio 8751
PRO PR:P15090
Proteomes UP000005640
Bgee P15090
CleanEx HS_FABP4
ExpressionAtlas P15090
Genevestigator P15090
GO GO:0005737
GO:0070062
GO:0005811
GO:0005634
GO:0005504
GO:0005215
GO:0050873
GO:0071285
GO:0042632
GO:0001816
GO:0006469
GO:0045892
GO:0050729
GO:0044281
GO:0019433
GO:0050872
Gene3D 2.40.128.20
InterPro IPR012674
IPR011038
IPR000463
IPR000566
Pfam PF00061
PRINTS PR00178
SUPFAM SSF50814
PROSITE PS00214

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006869

lipid transport

PMID:24700313[1]

ECO:0000314

P

Table 3. The size the cells are related to FABP4 expression levels in epicardial and subcutaneous stromal cells.

complete
CACAO 10042

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:24603714[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04117

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04117

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04117

C

Seeded From UniProt

complete

enables

GO:0036041

long-chain fatty acid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04117

F

Seeded From UniProt

complete

enables

GO:0005324

long-chain fatty acid transporter activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04117

F

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P04117

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0071285

cellular response to lithium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

enables

GO:0051427

hormone receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

F

Seeded From UniProt

complete

involved_in

GO:0050873

brown fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0050872

white fat cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0050729

positive regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0042632

cholesterol homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

enables

GO:0036041

long-chain fatty acid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

F

Seeded From UniProt

complete

involved_in

GO:0015909

long-chain fatty acid transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

involved_in

GO:0006469

negative regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

C

Seeded From UniProt

complete

enables

GO:0005324

long-chain fatty acid transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

F

Seeded From UniProt

complete

involved_in

GO:0001816

cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P04117
ensembl:ENSMUSP00000029041

P

Seeded From UniProt

complete

enables

GO:0005504

fatty acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033073

F

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000463
InterPro:IPR031259

F

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033073

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:2481498[4]
PMID:16130169[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0005504

fatty acid binding

PMID:2481498[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019433

triglyceride catabolic process

Reactome:R-HSA-163560

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5334794

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005811

lipid droplet

Reactome:R-HSA-560510

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0446

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Agra, RM et al. (2014) Differential association of S100A9, an inflammatory marker, and p53, a cell cycle marker, expression with epicardial adipocyte size in patients with cardiovascular disease. Inflammation 37 1504-12 PubMed GONUTS page
  2. ↑ Syamsunarno, MR et al. (2014) Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. PLoS ONE 9 e90825 PubMed GONUTS page
  3. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  4. ↑ 4.0 4.1 Baxa, CA et al. (1989) Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA. Biochemistry 28 8683-90 PubMed GONUTS page
  5. ↑ Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
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