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HUMAN:F5H8D7
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | XRCC1 (ECO:0000313 with Ensembl:ENSP00000443671) | |
| Protein Name(s) | DNA repair protein XRCC1 (ECO:0000313 with Ensembl:ENSP00000443671) | |
| External Links | ||
| UniProt | F5H8D7 | |
| EMBL | AC006276 AC018758 KC877750 L34079 | |
| ProteinModelPortal | F5H8D7 | |
| Ensembl | ENST00000543982 | |
| UCSC | uc010xwp.1 | |
| HGNC | HGNC:12828 | |
| GeneTree | ENSGT00390000004140 | |
| SignaLink | F5H8D7 | |
| ChiTaRS | XRCC1 | |
| NextBio | 35509558 | |
| Proteomes | UP000005640 | |
| Bgee | F5H8D7 | |
| GO | GO:0005634 GO:0003684 GO:0000012 | |
| Gene3D | 2.60.120.260 3.40.50.10190 | |
| InterPro | IPR001357 IPR008979 IPR002706 | |
| Pfam | PF00533 PF01834 | |
| SMART | SM00292 | |
| SUPFAM | SSF49785 SSF52113 | |
| PROSITE | PS50172 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006284 |
base-excision repair |
ECO:0000315 |
P |
Scaffolding protein, XRCC1, is involved in the coordination of DNA repair by interacting with components of the BER and single-strand break repair pathways. Figure 1 shows that XRCC1 is downregulated in breast cancer patients. This demonstrates the possibility of XRCC1 to be targeted to enhance the effect of DNA damaging agents in BRCAX patients. This can allow an increased interaction with BER if XRCC1 is targeted to be upregulated which can increase effectiveness of BER. |
complete | |||||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000012 |
single strand break repair |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003684 |
damaged DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
This is an uncurated TrEMBL record for a protein that has a curated SwissProt record. Use HUMAN:XRCC1 for annotation.
References
See Help:References for how to manage references in GONUTS.
- ↑ De Summa, S et al. (2014) Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. Cell Death Dis 5 e1076 PubMed GONUTS page
