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HUMAN:F5H8D7

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) XRCC1 (ECO:0000313 with Ensembl:ENSP00000443671)
Protein Name(s) DNA repair protein XRCC1 (ECO:0000313 with Ensembl:ENSP00000443671)
External Links
UniProt F5H8D7
EMBL AC006276
AC018758
KC877750
L34079
ProteinModelPortal F5H8D7
Ensembl ENST00000543982
UCSC uc010xwp.1
HGNC HGNC:12828
GeneTree ENSGT00390000004140
SignaLink F5H8D7
ChiTaRS XRCC1
NextBio 35509558
Proteomes UP000005640
Bgee F5H8D7
GO GO:0005634
GO:0003684
GO:0000012
Gene3D 2.60.120.260
3.40.50.10190
InterPro IPR001357
IPR008979
IPR002706
Pfam PF00533
PF01834
SMART SM00292
SUPFAM SSF49785
SSF52113
PROSITE PS50172

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006284

base-excision repair

PMID:24556691[1]

ECO:0000315

P

Scaffolding protein, XRCC1, is involved in the coordination of DNA repair by interacting with components of the BER and single-strand break repair pathways.

Figure 1 shows that XRCC1 is downregulated in breast cancer patients. This demonstrates the possibility of XRCC1 to be targeted to enhance the effect of DNA damaging agents in BRCAX patients. This can allow an increased interaction with BER if XRCC1 is targeted to be upregulated which can increase effectiveness of BER.

complete
CACAO 9688

part_of

GO:0005634

nucleus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000012

single strand break repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002706

P

Seeded From UniProt

complete

enables

GO:0003684

damaged DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002706

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002706

C

Seeded From UniProt

complete

Notes

This is an uncurated TrEMBL record for a protein that has a curated SwissProt record. Use HUMAN:XRCC1 for annotation.

References

See Help:References for how to manage references in GONUTS.

  1. De Summa, S et al. (2014) Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. Cell Death Dis 5 e1076 PubMed GONUTS page