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HUMAN:EVI1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MECOM (synonyms: EVI1) | |
| Protein Name(s) | MDS1 and EVI1 complex locus protein EVI1
Ecotropic virus integration site 1 protein homolog EVI-1 | |
| External Links | ||
| UniProt | Q03112 | |
| EMBL | X54989 S69002 AK292865 AK304098 BX640908 BX647613 AC007849 AC024099 AC069220 AC074033 AC078985 CH471052 CH471052 CH471052 BC031019 BC130520 BC143951 BC143952 S82592 | |
| CCDS | CCDS3205.1 CCDS54669.1 CCDS54670.1 | |
| PIR | A60191 S41705 | |
| RefSeq | NP_001098547.3 NP_001098548.2 NP_001157471.1 NP_001157472.1 NP_001192123.1 NP_004982.2 NP_005232.2 XP_005247276.1 XP_005247277.1 XP_005247278.1 XP_005247280.1 XP_006713599.1 | |
| UniGene | Hs.744090 | |
| ProteinModelPortal | Q03112 | |
| SMR | Q03112 | |
| BioGrid | 108423 | |
| DIP | DIP-38639N | |
| IntAct | Q03112 | |
| STRING | 9606.ENSP00000264674 | |
| PhosphoSite | Q03112 | |
| DMDM | 145559472 | |
| MaxQB | Q03112 | |
| PaxDb | Q03112 | |
| PRIDE | Q03112 | |
| DNASU | 2122 | |
| Ensembl | ENST00000264674 ENST00000433243 ENST00000464456 ENST00000468789 ENST00000472280 | |
| GeneID | 2122 | |
| KEGG | hsa:2122 | |
| UCSC | uc003ffi.3 uc003ffj.3 uc003ffk.2 uc011bpi.1 uc011bpj.1 | |
| CTD | 2122 | |
| GeneCards | GC03M168802 | |
| H-InvDB | HIX0003836 | |
| HGNC | HGNC:3498 | |
| HPA | HPA046537 | |
| MIM | 165215 | |
| neXtProt | NX_Q03112 | |
| Orphanet | 52688 | |
| PharmGKB | PA27912 | |
| eggNOG | COG5048 | |
| GeneTree | ENSGT00530000063676 | |
| HOVERGEN | HBG005619 | |
| InParanoid | Q03112 | |
| KO | K04462 | |
| OrthoDB | EOG72G16H | |
| PhylomeDB | Q03112 | |
| TreeFam | TF315309 | |
| SignaLink | Q03112 | |
| ChiTaRS | MECOM | |
| GeneWiki | MECOM | |
| GenomeRNAi | 2122 | |
| NextBio | 8579 | |
| Proteomes | UP000005640 | |
| Bgee | Q03112 | |
| CleanEx | HS_EVI1 | |
| ExpressionAtlas | Q03112 | |
| Genevestigator | Q03112 | |
| GO | GO:0016607 GO:0005634 GO:0003677 GO:0046872 GO:0042803 GO:0003700 GO:0006915 GO:0030154 GO:0071425 GO:0046329 GO:0043069 GO:0045892 GO:0045893 GO:0051726 GO:0006351 | |
| Gene3D | 3.30.160.60 | |
| InterPro | IPR030413 IPR007087 IPR015880 IPR013087 | |
| PANTHER | PTHR24393 | |
| Pfam | PF00096 | |
| SMART | SM00355 | |
| PROSITE | PS00028 PS50157 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
enables |
GO:0046974 |
histone methyltransferase activity (H3-K9 specific) |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070828 |
heterochromatin organization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ECO:0005556 |
multiple sequence alignment evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071425 |
hematopoietic stem cell proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051726 |
regulation of cell cycle |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046329 |
negative regulation of JNK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043069 |
negative regulation of programmed cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0000118 |
histone deacetylase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006357 |
regulation of transcription by RNA polymerase II |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0000981 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034968 |
histone lysine methylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0018024 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051567 |
histone H3-K9 methylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046974 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-5634802 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8943817 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Chakraborty, S et al. (2001) Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J. Biol. Chem. 276 44936-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kurokawa, M et al. (2000) The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death. EMBO J. 19 2958-68 PubMed GONUTS page
- ↑ 3.0 3.1 Shimabe, M et al. (2009) Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene 28 4364-74 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Nitta, E et al. (2005) Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP. Oncogene 24 6165-73 PubMed GONUTS page
- ↑ Fears, S et al. (1996) Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family. Proc. Natl. Acad. Sci. U.S.A. 93 1642-7 PubMed GONUTS page
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- GO:0030512 ! negative regulation of transforming growth factor beta receptor signaling pathway
- GO:0046329 ! negative regulation of JNK cascade
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0043069 ! negative regulation of programmed cell death
- GO:0016607 ! nuclear speck
- GO:0003676 ! nucleic acid binding
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
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