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HUMAN:ERO1A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ERO1L | |
| Protein Name(s) | ERO1-like protein alpha
ERO1-L ERO1-L-alpha Endoplasmic oxidoreductin-1-like protein Oxidoreductin-1-L-alpha | |
| External Links | ||
| UniProt | Q96HE7 | |
| EMBL | AF081886 AF123887 AY358463 AK292839 AL133453 BC008674 BC012941 | |
| CCDS | CCDS9709.1 | |
| RefSeq | NP_055399.1 | |
| UniGene | Hs.592304 | |
| PDB | 3AHQ 3AHR | |
| PDBsum | 3AHQ 3AHR | |
| ProteinModelPortal | Q96HE7 | |
| SMR | Q96HE7 | |
| BioGrid | 119025 | |
| IntAct | Q96HE7 | |
| MINT | MINT-144080 | |
| STRING | 9606.ENSP00000379042 | |
| BindingDB | Q96HE7 | |
| ChEMBL | CHEMBL1671609 | |
| PhosphoSite | Q96HE7 | |
| DMDM | 50400608 | |
| MaxQB | Q96HE7 | |
| PaxDb | Q96HE7 | |
| PeptideAtlas | Q96HE7 | |
| PRIDE | Q96HE7 | |
| DNASU | 30001 | |
| Ensembl | ENST00000395686 | |
| GeneID | 30001 | |
| KEGG | hsa:30001 | |
| UCSC | uc001wzv.3 | |
| CTD | 30001 | |
| GeneCards | GC14M053106 | |
| HGNC | HGNC:13280 | |
| HPA | CAB034294 HPA026653 HPA030053 | |
| MIM | 615435 | |
| neXtProt | NX_Q96HE7 | |
| PharmGKB | PA27862 | |
| eggNOG | COG5061 | |
| GeneTree | ENSGT00390000007753 | |
| HOGENOM | HOG000012778 | |
| HOVERGEN | HBG051507 | |
| InParanoid | Q96HE7 | |
| KO | K10950 | |
| OMA | CHSDEVP | |
| OrthoDB | EOG7PP579 | |
| PhylomeDB | Q96HE7 | |
| TreeFam | TF314471 | |
| Reactome | REACT_15550 REACT_172715 | |
| ChiTaRS | ERO1L | |
| EvolutionaryTrace | Q96HE7 | |
| GeneWiki | ERO1L | |
| GenomeRNAi | 30001 | |
| NextBio | 52816 | |
| PRO | PR:Q96HE7 | |
| Proteomes | UP000005640 | |
| Bgee | Q96HE7 | |
| CleanEx | HS_ERO1L | |
| ExpressionAtlas | Q96HE7 | |
| Genevestigator | Q96HE7 | |
| GO | GO:0005783 GO:0005788 GO:0005789 GO:0043231 GO:0016020 GO:0016491 GO:0016671 GO:0003756 GO:0015035 GO:0019471 GO:0050873 GO:0045454 GO:0044267 GO:0006464 GO:0051085 GO:0030968 GO:0030198 GO:0070059 GO:0006457 GO:0022417 GO:0051209 GO:0034976 GO:0009266 | |
| InterPro | IPR007266 | |
| PANTHER | PTHR12613 | |
| Pfam | PF04137 | |
| PIRSF | PIRSF017205 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051209 |
release of sequestered calcium ion into cytosol |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051085 |
chaperone cofactor-dependent protein refolding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034975 |
protein folding in endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261274 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015035 |
protein disulfide oxidoreductase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1354385 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000289179 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261274 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051209 |
release of sequestered calcium ion into cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050873 |
brown fat cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030968 |
endoplasmic reticulum unfolded protein response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022417 |
protein maturation by protein folding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019471 |
4-hydroxyproline metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0015035 |
protein disulfide oxidoreductase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006457 |
protein folding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R180 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071456 |
cellular response to hypoxia |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R4A1 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R4A1 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010260 |
animal organ senescence |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R4A1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016671 |
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009266 |
response to temperature stimulus |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006464 |
cellular protein modification process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006457 |
protein folding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034599 |
cellular response to oxidative stress |
Reactome:R-HSA-3299685 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
Reactome:R-HSA-3341296 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 2.0 2.1 Mezghrani, A et al. (2001) Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO J. 20 6288-96 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 Cabibbo, A et al. (2000) ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J. Biol. Chem. 275 4827-33 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
c
e
i
o
- GO:0019471 ! obsolete 4-hydroxyproline metabolic process
- GO:0010260 ! obsolete animal organ senescence
- GO:0051085 ! obsolete chaperone cofactor-dependent protein refolding
- GO:0055114 ! obsolete oxidation-reduction process
- GO:0022417 ! obsolete protein maturation by protein folding
- GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
- GO:0016491 ! oxidoreductase activity
p
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