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HUMAN:ELF1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ELF1
Protein Name(s) ETS-related transcription factor Elf-1

E74-like factor 1

External Links
UniProt P32519
EMBL M82882
AK304289
AL157877
CH471075
BC030507
CCDS CCDS9374.1
PIR A43361
RefSeq NP_001138825.1
NP_758961.1
XP_005266333.1
XP_005266334.1
UniGene Hs.135646
ProteinModelPortal P32519
SMR P32519
BioGrid 108312
DIP DIP-185N
IntAct P32519
MINT MINT-144425
STRING 9606.ENSP00000239882
PhosphoSite P32519
DMDM 212288097
MaxQB P32519
PaxDb P32519
PRIDE P32519
DNASU 1997
Ensembl ENST00000239882
GeneID 1997
KEGG hsa:1997
UCSC uc001uxs.3
uc010tfc.2
CTD 1997
GeneCards GC13M041506
HGNC HGNC:3316
HPA CAB005172
HPA001755
HPA048866
MIM 189973
neXtProt NX_P32519
PharmGKB PA27744
eggNOG NOG291231
GeneTree ENSGT00760000118996
HOGENOM HOG000049253
HOVERGEN HBG007183
InParanoid P32519
KO K09428
OMA NVMEDEQ
OrthoDB EOG73RBD1
PhylomeDB P32519
TreeFam TF318679
ChiTaRS ELF1
GenomeRNAi 1997
NextBio 8077
PRO PR:P32519
Proteomes UP000005640
Bgee P32519
CleanEx HS_ELF1
ExpressionAtlas P32519
Genevestigator P32519
GO GO:0005634
GO:0000978
GO:0001077
GO:0000981
GO:0003700
GO:0030154
GO:0050860
GO:0045944
GO:0045893
GO:0001817
GO:0006366
Gene3D 1.10.10.10
InterPro IPR000418
IPR022084
IPR011991
Pfam PF12310
PF00178
PRINTS PR00454
SMART SM00413
PROSITE PS00345
PS00346
PS50061

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:19274049[1]

ECO:0000255

match to sequence model evidence used in manual assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

GO_REF:0000113

ECO:0005556

multiple sequence alignment evidence used in manual assertion

UniProtKB:Q8R4Z4

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:8756667[2]

ECO:0000314

direct assay evidence used in manual assertion

P

has_regulation_target:(NCBI_Gene:4067)

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

PMID:8756667[2]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:8756667[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19674970[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:14970218[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:19674970[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:1527846[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:19674970[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:14970218[4]

ECO:0000305

curator inference used in manual assertion

GO:0003700

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:14970218[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109336
PANTHER:PTN000218930

P

Seeded From UniProt

complete

involved_in

GO:0006357

regulation of transcription by RNA polymerase II

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95455
MGI:MGI:95610
MGI:MGI:98282
PANTHER:PTN000218930
UniProtKB:Q15723

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000097
FB:FBgn0000567
FB:FBgn0003118
MGI:MGI:101762
MGI:MGI:107180
MGI:MGI:109637
MGI:MGI:1335079
MGI:MGI:1353422
MGI:MGI:2449712
MGI:MGI:95455
MGI:MGI:95554
MGI:MGI:95610
MGI:MGI:98282
MGI:MGI:99423
PANTHER:PTN000218930
RGD:1359607
RGD:1598663
RGD:2583
UniProtKB:P14921
UniProtKB:P17947
UniProtKB:P19419
UniProtKB:P32519
UniProtKB:P41161
UniProtKB:Q01543
UniProtKB:Q06546
WB:WBGene00002990
WB:WBGene00017687

C

Seeded From UniProt

complete

enables

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000218930
UniProtKB:Q15723

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:G3V9V2
ensembl:ENSRNOP00000060815

P

Seeded From UniProt

complete

involved_in

GO:0050860

negative regulation of T cell receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60775
ensembl:ENSMUSP00000046515

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60775
ensembl:ENSMUSP00000046515

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60775
ensembl:ENSMUSP00000046515

C

Seeded From UniProt

complete

involved_in

GO:0001817

regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60775
ensembl:ENSMUSP00000046515

P

Seeded From UniProt

complete

enables

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60775
ensembl:ENSMUSP00000046515

F

Seeded From UniProt

complete

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60775
ensembl:ENSMUSP00000046515

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000418

F

Seeded From UniProt

complete

involved_in

GO:0050855

regulation of B cell receptor signaling pathway

Reactome:R-HSA-8939245

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8938965
Reactome:R-HSA-8938938
Reactome:R-HSA-8938913

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0001959

regulation of cytokine-mediated signaling pathway

Reactome:R-HSA-8939247

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Oettgen, P et al. (1996) Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Mol. Cell. Biol. 16 5091-106 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Song, H et al. (2009) Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. J. Biol. Chem. 284 29109-24 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Cho, JY et al. (2004) Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. J. Biol. Chem. 279 19512-22 PubMed GONUTS page
  5. ↑ Leiden, JM et al. (1992) A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. J. Virol. 66 5890-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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