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HUMAN:EIF1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | EIF1 (synonyms: SUI1) | |
| Protein Name(s) | Eukaryotic translation initiation factor 1
eIF1 A121 Protein translation factor SUI1 homolog Sui1iso1 | |
| External Links | ||
| UniProt | P41567 | |
| EMBL | L26247 AF083441 AF100737 BC005118 BC008710 | |
| CCDS | CCDS11403.1 | |
| PIR | JC2042 | |
| RefSeq | NP_005792.1 | |
| UniGene | Hs.150580 | |
| PDB | 2IF1 4KZX 4KZY | |
| PDBsum | 2IF1 4KZX 4KZY | |
| ProteinModelPortal | P41567 | |
| SMR | P41567 | |
| BioGrid | 115504 | |
| DIP | DIP-50783N | |
| IntAct | P41567 | |
| MINT | MINT-1432975 | |
| STRING | 9606.ENSP00000419449 | |
| PhosphoSite | P41567 | |
| MaxQB | P41567 | |
| PaxDb | P41567 | |
| PeptideAtlas | P41567 | |
| PRIDE | P41567 | |
| DNASU | 10209 | |
| Ensembl | ENST00000469257 | |
| GeneID | 10209 | |
| KEGG | hsa:10209 | |
| UCSC | uc002hxj.3 | |
| CTD | 10209 | |
| GeneCards | GC17P039845 | |
| HGNC | HGNC:3249 | |
| HPA | HPA043003 | |
| neXtProt | NX_P41567 | |
| PharmGKB | PA27683 | |
| eggNOG | COG0023 | |
| HOGENOM | HOG000279813 | |
| HOVERGEN | HBG000295 | |
| InParanoid | P41567 | |
| KO | K03113 | |
| PhylomeDB | P41567 | |
| TreeFam | TF314417 | |
| EvolutionaryTrace | P41567 | |
| GeneWiki | EIF1 | |
| GenomeRNAi | 10209 | |
| NextBio | 38652 | |
| PRO | PR:P41567 | |
| Proteomes | UP000005640 | |
| Bgee | P41567 | |
| CleanEx | HS_EIF1 | |
| ExpressionAtlas | P41567 | |
| Genevestigator | P41567 | |
| GO | GO:0005737 GO:0044822 GO:0008135 GO:0003743 GO:0009048 GO:0006446 GO:0006950 | |
| Gene3D | 3.30.780.10 | |
| InterPro | IPR005874 IPR001950 | |
| Pfam | PF01253 | |
| PIRSF | PIRSF004499 | |
| SUPFAM | SSF55159 | |
| TIGRFAMs | TIGR01160 | |
| PROSITE | PS50296 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006446 |
regulation of translational initiation |
ECO:0000314 |
P |
Fig 2-C,D Show that that over expression of EIF1 protein leads to decreased expression of firefly luciferase constructs downstream of a poor-context AUG start codons and other non-AUG start codons. |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043024 |
ribosomal small subunit binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000044132 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016282 |
eukaryotic 43S preinitiation complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000044132 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000044132 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000044131 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009048 |
dosage compensation by inactivation of X chromosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P48024 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008135 |
translation factor activity, RNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006446 |
regulation of translational initiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Loughran, G et al. (2012) Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5. Nucleic Acids Res. 40 2898-906 PubMed GONUTS page
- ↑ 2.0 2.1 Bohnsack, MT et al. (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 21 6205-15 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Sheikh, MS et al. (1999) Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). J. Biol. Chem. 274 16487-93 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Fields, C & Adams, MD (1994) Expressed sequence tags identify a human isolog of the suil translation initiation factor. Biochem. Biophys. Res. Commun. 198 288-91 PubMed GONUTS page
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