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HUMAN:EF1A1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | EEF1A1 (synonyms: EEF1A, EF1A, LENG7) | |
Protein Name(s) | Elongation factor 1-alpha 1
EF-1-alpha-1 Elongation factor Tu EF-Tu Eukaryotic elongation factor 1 A-1 eEF1A-1 Leukocyte receptor cluster member 7 | |
External Links | ||
UniProt | P68104 | |
EMBL | X03558 J04617 X16869 AY043301 BC008587 BC009733 BC009875 BC010735 BC012891 BC014224 BC018150 BC018641 BC021686 BC028674 BC038339 BC057391 BC066893 BC071619 BC072385 BC082268 X03689 M29548 | |
CCDS | CCDS4980.1 | |
PIR | B24977 | |
RefSeq | NP_001393.1 | |
UniGene | Hs.535192 Hs.586423 Hs.745122 | |
PDB | 1SYW | |
PDBsum | 1SYW | |
ProteinModelPortal | P68104 | |
SMR | P68104 | |
BioGrid | 108237 | |
IntAct | P68104 | |
MINT | MINT-1180846 | |
STRING | 9606.ENSP00000330054 | |
BindingDB | P68104 | |
ChEMBL | CHEMBL1795120 | |
PhosphoSite | P68104 | |
DMDM | 55584035 | |
OGP | P68104 | |
SWISS-2DPAGE | P68104 | |
UCD-2DPAGE | P68104 | |
MaxQB | P68104 | |
PaxDb | P68104 | |
PRIDE | P68104 | |
DNASU | 1915 | |
Ensembl | ENST00000309268 ENST00000316292 ENST00000331523 | |
GeneID | 1915 | |
KEGG | hsa:1915 | |
UCSC | uc003phi.3 | |
CTD | 1915 | |
GeneCards | GC06M074225 | |
H-InvDB | HIX0020005 HIX0032108 HIX0033669 HIX0169110 | |
HGNC | HGNC:3189 | |
HPA | HPA051759 HPA053862 HPA056990 | |
MIM | 130590 | |
neXtProt | NX_P68104 | |
PharmGKB | PA27625 | |
eggNOG | COG5256 | |
HOGENOM | HOG000229291 | |
HOVERGEN | HBG000179 | |
InParanoid | P68104 | |
KO | K03231 | |
OMA | AIRDMGM | |
OrthoDB | EOG7NKKK3 | |
PhylomeDB | P68104 | |
TreeFam | TF300304 | |
Reactome | REACT_1404 REACT_1477 REACT_200744 | |
SignaLink | P68104 | |
ChiTaRS | EEF1A1 | |
GeneWiki | Eukaryotic_translation_elongation_factor_1_alpha_1 | |
GenomeRNAi | 1915 | |
NextBio | 7799 | |
PMAP-CutDB | P68104 | |
PRO | PR:P68104 | |
Proteomes | UP000005640 | |
Bgee | P68104 | |
CleanEx | HS_EEF1A1 | |
ExpressionAtlas | P68104 | |
Genevestigator | P68104 | |
GO | GO:0005737 GO:0005829 GO:0005853 GO:0005615 GO:0070062 GO:0016020 GO:0005730 GO:0005634 GO:0005886 GO:0005525 GO:0003924 GO:0044822 GO:0019901 GO:0003746 GO:0044267 GO:0071364 GO:0010467 GO:0006355 GO:0006351 GO:0006412 GO:0006414 | |
Gene3D | 3.40.50.300 | |
HAMAP | MF_00118_A | |
InterPro | IPR000795 IPR027417 IPR009000 IPR009001 IPR004539 IPR004161 IPR004160 | |
Pfam | PF00009 PF03144 PF03143 | |
PRINTS | PR00315 | |
SUPFAM | SSF50447 SSF50465 SSF52540 | |
TIGRFAMs | TIGR00483 | |
PROSITE | PS00301 PS51722 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:1900022 |
regulation of D-erythro-sphingosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019900 |
kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0098574 |
cytoplasmic side of lysosomal membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:1904714 |
regulation of chaperone-mediated autophagy |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0030864 |
cortical actin cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0032587 |
ruffle membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000049 |
tRNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:1001608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:1001608) |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
produced_by:(CL:0000236) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000019) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071364 |
cellular response to epidermal growth factor stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006414 |
translational elongation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1096317 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006412 |
translation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000561878 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0003924 |
GTPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000561878 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003746 |
translation elongation factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1096317 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P10126 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P10126 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005516 |
calmodulin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P10126 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0003746 |
translation elongation factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003924 |
GTPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005525 |
GTP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006414 |
translational elongation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
NOT|part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
NOT|part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006414 |
translational elongation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005853 |
eukaryotic translation elongation factor 1 complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005525 |
GTP binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003746 |
translation elongation factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:1904813 |
ficolin-1-rich granule lumen |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043312 |
neutrophil degranulation |
Reactome:R-HSA-6798695 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0034774 |
secretory granule lumen |
Reactome:R-HSA-6798748 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8932413 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6800434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0006414 |
translational elongation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0003746 |
translation elongation factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005525 |
GTP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Leclercq, TM et al. (2008) Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. J. Biol. Chem. 283 9606-14 PubMed GONUTS page
- ↑ Boratkó, A et al. (2015) Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. Int. J. Biochem. Cell Biol. 69 105-13 PubMed GONUTS page
- ↑ 3.0 3.1 Bandyopadhyay, U et al. (2010) Identification of regulators of chaperone-mediated autophagy. Mol. Cell 39 535-47 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Zhong, D et al. (2009) The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration. J. Cell. Sci. 122 414-24 PubMed GONUTS page
- ↑ Yang, YF et al. (2008) The possible interaction of CDA14 and protein elongation factor 1alpha. Biochim. Biophys. Acta 1784 312-8 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Maruyama, T et al. (2007) Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. Clin. Exp. Immunol. 147 164-75 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Bohnsack, MT et al. (2002) Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 21 6205-15 PubMed GONUTS page
- ↑ Mingot, JM et al. (2013) eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex. Cell Rep 5 727-37 PubMed GONUTS page
- ↑ 9.0 9.1 Sanders, J et al. (1996) Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. J. Cell. Sci. 109 ( Pt 5) 1113-7 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Wubbolts, R et al. (2003) Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J. Biol. Chem. 278 10963-72 PubMed GONUTS page
- ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
- ↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Gangwani, L et al. (1998) Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells. J. Cell Biol. 143 1471-84 PubMed GONUTS page
- ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ 20.0 20.1 Eckhardt, K et al. (2007) Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1. Cell. Physiol. Biochem. 20 227-40 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 21.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Lund, A et al. (1996) Assignment of human elongation factor 1alpha genes: EEF1A maps to chromosome 6q14 and EEF1A2 to 20q13.3. Genomics 36 359-61 PubMed GONUTS page
- ↑ Uetsuki, T et al. (1989) Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha. J. Biol. Chem. 264 5791-8 PubMed GONUTS page
- ↑ 24.0 24.1 Brands, JH et al. (1986) The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites. Eur. J. Biochem. 155 167-71 PubMed GONUTS page
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