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HUMAN:DYRK2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DYRK2 | |
| Protein Name(s) | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | |
| External Links | ||
| UniProt | Q92630 | |
| EMBL | Y13493 AK313937 CH471054 BC005809 BC006375 Y09216 | |
| CCDS | CCDS8978.1 CCDS8979.1 | |
| RefSeq | NP_003574.1 NP_006473.2 | |
| UniGene | Hs.173135 | |
| PDB | 3K2L 3KVW 4AZF | |
| PDBsum | 3K2L 3KVW 4AZF | |
| ProteinModelPortal | Q92630 | |
| SMR | Q92630 | |
| BioGrid | 114023 | |
| IntAct | Q92630 | |
| MINT | MINT-1469581 | |
| STRING | 9606.ENSP00000342105 | |
| BindingDB | Q92630 | |
| ChEMBL | CHEMBL4376 | |
| GuidetoPHARMACOLOGY | 2011 | |
| PhosphoSite | Q92630 | |
| DMDM | 148887370 | |
| PaxDb | Q92630 | |
| PRIDE | Q92630 | |
| DNASU | 8445 | |
| Ensembl | ENST00000344096 ENST00000393555 | |
| GeneID | 8445 | |
| KEGG | hsa:8445 | |
| UCSC | uc001str.4 | |
| CTD | 8445 | |
| GeneCards | GC12P068042 | |
| HGNC | HGNC:3093 | |
| HPA | HPA027230 HPA056902 | |
| MIM | 603496 | |
| neXtProt | NX_Q92630 | |
| PharmGKB | PA27550 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00760000119032 | |
| HOGENOM | HOG000220863 | |
| HOVERGEN | HBG051426 | |
| InParanoid | Q92630 | |
| KO | K18669 | |
| OMA | HTIGGSK | |
| OrthoDB | EOG77127N | |
| PhylomeDB | Q92630 | |
| TreeFam | TF314624 | |
| BRENDA | 2.7.12.1 | |
| SignaLink | Q92630 | |
| ChiTaRS | DYRK2 | |
| EvolutionaryTrace | Q92630 | |
| GeneWiki | DYRK2 | |
| GenomeRNAi | 8445 | |
| NextBio | 31596 | |
| PRO | PR:Q92630 | |
| Proteomes | UP000005640 | |
| Bgee | Q92630 | |
| CleanEx | HS_DYRK2 | |
| ExpressionAtlas | Q92630 | |
| Genevestigator | Q92630 | |
| GO | GO:0005737 GO:0005634 GO:0030529 GO:0000151 GO:0005524 GO:0000287 GO:0030145 GO:0004674 GO:0004712 GO:0004713 GO:0043130 GO:0006974 GO:0042771 GO:0051534 GO:0018108 GO:0045725 GO:0006468 GO:0007224 | |
| InterPro | IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| Pfam | PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045786 |
negative regulation of cell cycle |
ECO:0000315 |
P |
DYRK2 phosphorylates the ubiquination of transcription factors associated with cell cycle progression. Knockdown or knockouts of DYRK2 increase cell proliferation. See Figure 1 |
complete | |||||
|
involved_in |
GO:0070885 |
negative regulation of calcineurin-NFAT signaling cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045725 |
positive regulation of glycogen biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030145 |
manganese ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007224 |
smoothened signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000151 |
ubiquitin ligase complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:1990904 |
ribonucleoprotein complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U4C9 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004712 |
protein serine/threonine/tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901796 |
regulation of signal transduction by p53 class mediator |
Reactome:R-HSA-5633007 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-6798374 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
Reactome:R-HSA-6798374 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Taira, N et al. (2012) DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. J. Clin. Invest. 122 859-72 PubMed GONUTS page
- ↑ Gwack, Y et al. (2006) A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature 441 646-50 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Woods, YL et al. (2001) The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase. Biochem. J. 355 609-15 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Taira, N et al. (2007) DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage. Mol. Cell 25 725-38 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Becker, W et al. (1998) Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273 25893-902 PubMed GONUTS page
- ↑ 6.0 6.1 Varjosalo, M et al. (2008) Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell 133 537-48 PubMed GONUTS page
- ↑ Taira, N et al. (2010) ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage. J. Biol. Chem. 285 4909-19 PubMed GONUTS page
- ↑ Maddika, S & Chen, J (2009) Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat. Cell Biol. 11 409-19 PubMed GONUTS page
i
n
p
- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0016310 ! phosphorylation
- GO:0045725 ! positive regulation of glycogen biosynthetic process
- Primates
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004712 ! protein serine/threonine/tyrosine kinase activity
- GO:0004674 ! protein serine/threonine kinase activity
- GO:0004713 ! protein tyrosine kinase activity
r
