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HUMAN:DUX4C
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | DUX4L9 (synonyms: DUX4C) | |
| Protein Name(s) | Double homeobox protein 4C
Double homeobox protein 4, centromeric DUX4c Double homeobox protein 4-like protein 9 | |
| External Links | ||
| UniProt | Q6RFH8 | |
| EMBL | AY500824 AF146191 | |
| ProteinModelPortal | Q6RFH8 | |
| SMR | Q6RFH8 | |
| STRING | 9606.ENSP00000410437 | |
| PhosphoSite | Q6RFH8 | |
| DMDM | 74710112 | |
| PaxDb | Q6RFH8 | |
| PRIDE | Q6RFH8 | |
| GeneCards | GC04M190943 | |
| H-InvDB | HIX0020902 | |
| HGNC | HGNC:33855 | |
| MIM | 615581 | |
| neXtProt | NX_Q6RFH8 | |
| eggNOG | NOG323819 | |
| HOVERGEN | HBG063255 | |
| InParanoid | Q6RFH8 | |
| PhylomeDB | Q6RFH8 | |
| PRO | PR:Q6RFH8 | |
| Proteomes | UP000005640 | |
| GO | GO:0005634 GO:0000976 GO:0008283 GO:0045944 GO:0010468 GO:0006351 | |
| Gene3D | 1.10.10.60 | |
| InterPro | IPR001356 IPR009057 IPR000047 | |
| Pfam | PF00046 | |
| PRINTS | PR00031 | |
| SMART | SM00389 | |
| SUPFAM | SSF46689 | |
| PROSITE | PS50071 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000976 |
transcription regulatory region sequence-specific DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0001404 |
invasive growth |
ECO:0000314 |
P |
Figure 3: The tumour tissues and cancer cell lines revealed that Nup214 and miR-133b expressions are negatively correlated. In vitro, Nup214 was significantly downregulated by ectopic miR-133b. |
complete | |||||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Dixit, M et al. (2007) DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1. Proc. Natl. Acad. Sci. U.S.A. 104 18157-62 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Ansseau, E et al. (2009) DUX4c is up-regulated in FSHD. It induces the MYF5 protein and human myoblast proliferation. PLoS ONE 4 e7482 PubMed GONUTS page
- ↑ Bhattacharjya, S et al. (2015) Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol. Cancer 14 42 PubMed GONUTS page
