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PMID:25743594
| Citation |
Bhattacharjya, S, Roy, K, Ganguly, A, Sarkar, S, Panda, CK, Bhattacharyya, D, Bhattacharyya, NP and Roychoudhury, S (2015) Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol. Cancer 14:42 |
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| Abstract |
Nucleoporins mediate nucleocytoplasmic exchange of macromolecules and several have been assigned active mitotic functions. Nucleoporins can participate in various mitotic functions like spindle assembly, kinetochore organisation and chromosome segregation- important for genome integrity. Pathways to genome integrity are frequently deregulated in cancer and many are regulated in part by microRNAs. Indeed, altered levels of numerous microRNAs have frequently been associated with tumorigenesis. Here, we unveil a microRNA-mediated regulation of the nucleoporin Nup214 and its downstream effect on genome integrity. |
| Links |
PubMed PMC4335456 Online version:10.1186/s12943-015-0299-z |
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Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001404: invasive growth |
ECO:0000314: |
P |
Figure 3: The tumour tissues and cancer cell lines revealed that Nup214 and miR-133b expressions are negatively correlated. In vitro, Nup214 was significantly downregulated by ectopic miR-133b. |
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Notes
See also
References
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